SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 8 SER A 191
ALA A 161
PHE A 121
GLU A 194
 None
 1.11A 1dmiA-3gqmA:
undetectable
1dmiB-3gqmA:
undetectable		 1dmiA-3gqmA:
20.62
1dmiB-3gqmA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 4 GLY A 141
LEU A 239
GLY A 237
ARG A 142
 None
 1.23A 1j7kA-3gqmA:
undetectable		 1j7kA-3gqmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		5 / 12 LEU A 214
LEU A 219
ALA A  94
LEU A 195
ARG A 142
 None
 1.38A 1kt5A-3gqmA:
undetectable		 1kt5A-3gqmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		5 / 11 LEU A 214
LEU A 219
ALA A  94
LEU A 195
ARG A 142
 None
 1.38A 1kt7A-3gqmA:
undetectable		 1kt7A-3gqmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		5 / 11 SER A  35
VAL A  38
LEU A  48
LEU A  26
LEU A 100
 None
 1.29A 2a15A-3gqmA:
undetectable		 2a15A-3gqmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		3 / 3 ASN A  95
ASN A  96
ARG A  51
 None
 0.82A 2rlcA-3gqmA:
undetectable		 2rlcA-3gqmA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z77_D_NCAD200_0
(PUTATIVE STEROID
ISOMERASE)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		5 / 9 SER A 200
LEU A 143
LEU A 214
LEU A 215
MET A 206
 None
 1.38A 2z77D-3gqmA:
0.0		 2z77D-3gqmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 5 LEU A  48
GLN A 250
LEU A 100
GLU A 103
 None
 1.02A 3h5gA-3gqmA:
undetectable
3h5gB-3gqmA:
undetectable		 3h5gA-3gqmA:
8.00
3h5gB-3gqmA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		5 / 9 ALA A  94
VAL A 138
ILE A 218
LEU A 198
ILE A 149
 None
 1.25A 3jw3B-3gqmA:
undetectable		 3jw3B-3gqmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 6 ILE A 230
VAL A 228
LEU A 173
LEU A 143
 None
 0.85A 3kp6A-3gqmA:
undetectable
3kp6B-3gqmA:
undetectable		 3kp6A-3gqmA:
19.22
3kp6B-3gqmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 6 ARG A 159
ARG A  15
VAL A 135
ASP A 150
 None
 1.34A 4xqeA-3gqmA:
undetectable		 4xqeA-3gqmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 6 ARG A 159
ARG A  15
VAL A 135
ASP A 150
 None
 1.36A 4xqeB-3gqmA:
undetectable		 4xqeB-3gqmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3gqm CELL INHIBITING
FACTOR (CIFBP)
(Burkholderia
pseudomallei) 		4 / 5 PHE A  98
THR A 111
ASP A  45
GLU A 103
 None
 1.36A 5ybbA-3gqmA:
undetectable		 5ybbA-3gqmA:
20.68