SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 10 LEU A 117
GLU A 113
LEU A 114
GLU A  82
LEU A  37
 None
SO4  A   4 ( 3.2A)
None
None
EDO  A   1 ( 4.6A)
 1.15A 1wopA-3graA:
undetectable		 1wopA-3graA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		4 / 6 SER A  41
ASP A  78
SER A  44
VAL A  47
 None
 1.32A 2hdnI-3graA:
undetectable
2hdnJ-3graA:
3.2
2hdnL-3graA:
2.2		 2hdnI-3graA:
10.31
2hdnJ-3graA:
21.01
2hdnL-3graA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 10 LEU A 138
VAL A 143
GLY A 142
GLY A 134
LEU A 114
 None
 0.65A 2v3kA-3graA:
2.8		 2v3kA-3graA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		4 / 5 ILE A  35
MET A 126
LEU A 117
LEU A 118
 None
 1.15A 2zb7A-3graA:
undetectable		 2zb7A-3graA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		3 / 3 PHE A  63
ASN A  56
PHE A  65
 None
 0.96A 2zbuD-3graA:
2.7		 2zbuD-3graA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		3 / 3 ASP A  33
PHE A  34
LEU A  36
 None
 0.57A 2zi9A-3graA:
undetectable		 2zi9A-3graA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 12 LEU A  99
GLY A 130
SER A 181
LEU A 118
LEU A 117
 None
 1.18A 3cjtG-3graA:
2.5		 3cjtG-3graA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		4 / 7 LEU A 199
LEU A 131
LEU A  52
LEU A 118
 None
 0.90A 3g8iA-3graA:
undetectable		 3g8iA-3graA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 9 LEU A 175
PHE A 173
LEU A 212
GLU A 209
GLY A 187
 None
 1.41A 3nxuB-3graA:
undetectable		 3nxuB-3graA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 12 GLY A 130
GLY A 134
ASN A 133
ALA A 188
LEU A 128
 None
 1.07A 3p2kC-3graA:
3.4		 3p2kC-3graA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 11 VAL A 143
ALA A 141
LEU A 118
LEU A 180
GLY A 130
 None
 0.98A 3zosA-3graA:
undetectable
3zosB-3graA:
undetectable		 3zosA-3graA:
23.08
3zosB-3graA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY
(Pseudomonas
putida) 		5 / 12 TYR A 147
GLY A 148
LEU A  98
PHE A  63
THR A 174
 None
 1.33A 4ze1A-3graA:
undetectable		 4ze1A-3graA:
17.04