SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3grc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		4 / 6 LEU A 567
ILE A 624
TYR A 592
VAL A 627
 None
 1.10A 1db1A-3grcA:
undetectable		 1db1A-3grcA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		4 / 6 HIS A 578
ASP A 555
ASP A 598
PRO A 557
 None
 1.14A 1ilqA-3grcA:
undetectable
1ilqC-3grcA:
undetectable		 1ilqA-3grcA:
18.52
1ilqC-3grcA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		4 / 8 SER A 628
ASP A 598
GLU A 633
GLU A 637
 None
 0.80A 1knyA-3grcA:
undetectable
1knyB-3grcA:
undetectable		 1knyA-3grcA:
21.46
1knyB-3grcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		3 / 3 MET A 566
GLU A 554
ASN A 600
 None
 0.94A 3a27A-3grcA:
2.7		 3a27A-3grcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		4 / 8 GLU A 633
VAL A 626
LEU A 599
ALA A 629
 None
 1.02A 3ax7A-3grcA:
undetectable		 3ax7A-3grcA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		5 / 12 SER A 579
ILE A 610
ASP A 616
ARG A 618
LEU A 613
 None
 1.24A 3iv6D-3grcA:
3.0		 3iv6D-3grcA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		5 / 12 SER A 646
THR A 647
ILE A 550
ARG A 664
LEU A 662
 None
 1.21A 3iv6D-3grcA:
3.0		 3iv6D-3grcA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		4 / 7 GLU A 633
VAL A 626
LEU A 599
ALA A 629
 None
 1.01A 3uniA-3grcA:
undetectable		 3uniA-3grcA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		3 / 3 LEU A 609
ILE A 610
ARG A 614
 None
 0.51A 4mk4B-3grcA:
4.0		 4mk4B-3grcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3grc SENSOR PROTEIN,
KINASE
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 601
LEU A 613
LEU A 609
ILE A 610
LEU A 622
 None
 1.05A 4zowA-3grcA:
undetectable		 4zowA-3grcA:
16.71