SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 1c9sB-3greA:
undetectable
1c9sC-3greA:
undetectable
1c9sB-3greA:
12.01
1c9sC-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 1c9sF-3greA:
undetectable
1c9sG-3greA:
undetectable
1c9sF-3greA:
12.01
1c9sG-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 ALA A1443
THR A1351
HIS A1279
ILE A1369
SER A1429
None
1.29A 1gtfA-3greA:
undetectable
1gtfK-3greA:
undetectable
1gtfA-3greA:
12.01
1gtfK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 1gtfA-3greA:
undetectable
1gtfB-3greA:
undetectable
1gtfA-3greA:
12.01
1gtfB-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 1gtfC-3greA:
undetectable
1gtfD-3greA:
undetectable
1gtfC-3greA:
12.01
1gtfD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 1gtfE-3greA:
undetectable
1gtfF-3greA:
undetectable
1gtfE-3greA:
12.01
1gtfF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 1gtfG-3greA:
undetectable
1gtfH-3greA:
undetectable
1gtfG-3greA:
12.01
1gtfH-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 1gtfH-3greA:
undetectable
1gtfI-3greA:
undetectable
1gtfH-3greA:
12.01
1gtfI-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.29A 1gtfI-3greA:
undetectable
1gtfJ-3greA:
undetectable
1gtfI-3greA:
12.01
1gtfJ-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
4 / 8 ARG A1190
ASN A1227
SER A1209
VAL A1234
None
1.25A 1u1jA-3greA:
undetectable
1u1jA-3greA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 ALA A1443
THR A1351
HIS A1279
ILE A1369
SER A1429
None
1.31A 1utdA-3greA:
undetectable
1utdB-3greA:
undetectable
1utdA-3greA:
12.01
1utdB-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 8 ALA A1443
THR A1351
HIS A1279
ILE A1369
SER A1429
None
1.30A 1utdB-3greA:
undetectable
1utdC-3greA:
undetectable
1utdB-3greA:
12.01
1utdC-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 ALA A1443
THR A1351
HIS A1279
ILE A1369
SER A1429
None
1.30A 1utdD-3greA:
undetectable
1utdE-3greA:
undetectable
1utdD-3greA:
12.01
1utdE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 8 ALA A1443
THR A1351
HIS A1279
ILE A1369
SER A1429
None
1.30A 1utdF-3greA:
undetectable
1utdG-3greA:
undetectable
1utdF-3greA:
12.01
1utdG-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 1utdA-3greA:
undetectable
1utdK-3greA:
undetectable
1utdA-3greA:
12.01
1utdK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 11 GLU A1281
ILE A1304
LEU A1302
TYR A1286
PHE A1316
None
1.14A 2dg9A-3greA:
undetectable
2dg9A-3greA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 12 ILE A1260
ILE A1239
PHE A1194
ALA A1193
GLU A1220
None
0.99A 2j0dA-3greA:
undetectable
2j0dA-3greA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 12 SER A1235
GLY A1295
ALA A1275
GLY A1253
LEU A1361
None
0.98A 2nyuB-3greA:
undetectable
2nyuB-3greA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 12 LEU A1360
GLY A1069
GLY A1451
ILE A1452
ILE A1369
None
1.01A 2pynA-3greA:
undetectable
2pynA-3greA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
3 / 3 ARG A1190
GLU A1364
SER A1235
None
0.86A 2xkkA-3greA:
undetectable
2xkkC-3greA:
undetectable
2xkkA-3greA:
20.70
2xkkC-3greA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
4 / 5 SER A1447
LEU A1075
GLY A1451
GLU A1079
None
1.07A 3aiaA-3greA:
undetectable
3aiaB-3greA:
undetectable
3aiaA-3greA:
19.63
3aiaB-3greA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 ILE A1427
ILE A1369
VAL A1383
GLY A1069
PRO A1439
None
0.96A 3elzC-3greA:
3.3
3elzC-3greA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 12 ASN A1347
GLY A1295
SER A1298
GLY A1272
ASP A1273
None
0.78A 3uboA-3greA:
undetectable
3uboA-3greA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 12 ASN A1347
ILE A1317
GLY A1295
GLY A1272
ASP A1273
None
0.97A 3uq6A-3greA:
undetectable
3uq6A-3greA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 12 ASN A1347
ILE A1317
GLY A1295
GLY A1272
ASP A1273
None
0.97A 3vasA-3greA:
undetectable
3vasA-3greA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 ASP A1149
ASP A1126
SER A1129
SER A1128
GLY A1103
None
1.24A 4xp1A-3greA:
undetectable
4xp1A-3greA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
4 / 7 THR A1278
PRO A1276
THR A1250
SER A1236
None
1.13A 5b6iA-3greA:
undetectable
5b6iA-3greA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 LEU A1071
ALA A1073
LEU A1075
MET A1076
LEU A1449
None
1.50A 5dxeB-3greA:
undetectable
5dxeB-3greA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5eeuA-3greA:
undetectable
5eeuB-3greA:
undetectable
5eeuA-3greA:
12.01
5eeuB-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.29A 5eeuC-3greA:
undetectable
5eeuD-3greA:
undetectable
5eeuC-3greA:
12.01
5eeuD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5eeuD-3greA:
undetectable
5eeuE-3greA:
undetectable
5eeuD-3greA:
12.01
5eeuE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5eeuE-3greA:
undetectable
5eeuF-3greA:
undetectable
5eeuE-3greA:
12.01
5eeuF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eeuJ-3greA:
undetectable
5eeuK-3greA:
undetectable
5eeuJ-3greA:
12.01
5eeuK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eevC-3greA:
undetectable
5eevD-3greA:
undetectable
5eevC-3greA:
12.01
5eevD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5eevD-3greA:
undetectable
5eevE-3greA:
undetectable
5eevD-3greA:
12.01
5eevE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5eevE-3greA:
undetectable
5eevF-3greA:
undetectable
5eevE-3greA:
12.01
5eevF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eevJ-3greA:
undetectable
5eevK-3greA:
undetectable
5eevJ-3greA:
12.01
5eevK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eewC-3greA:
undetectable
5eewD-3greA:
undetectable
5eewC-3greA:
12.01
5eewD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5eewD-3greA:
undetectable
5eewE-3greA:
undetectable
5eewD-3greA:
12.01
5eewE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5eewE-3greA:
undetectable
5eewF-3greA:
undetectable
5eewE-3greA:
12.01
5eewF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eewJ-3greA:
undetectable
5eewK-3greA:
undetectable
5eewJ-3greA:
12.01
5eewK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eexC-3greA:
undetectable
5eexD-3greA:
undetectable
5eexC-3greA:
12.01
5eexD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5eexD-3greA:
undetectable
5eexE-3greA:
undetectable
5eexD-3greA:
12.01
5eexE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5eexE-3greA:
undetectable
5eexF-3greA:
undetectable
5eexE-3greA:
12.01
5eexF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eexJ-3greA:
undetectable
5eexK-3greA:
undetectable
5eexJ-3greA:
12.01
5eexK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5eeyC-3greA:
undetectable
5eeyD-3greA:
undetectable
5eeyC-3greA:
12.01
5eeyD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5eeyD-3greA:
undetectable
5eeyE-3greA:
undetectable
5eeyD-3greA:
12.01
5eeyE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5eeyE-3greA:
undetectable
5eeyF-3greA:
undetectable
5eeyE-3greA:
12.01
5eeyF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5eeyJ-3greA:
undetectable
5eeyK-3greA:
undetectable
5eeyJ-3greA:
12.01
5eeyK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.29A 5eezC-3greA:
undetectable
5eezD-3greA:
undetectable
5eezC-3greA:
12.01
5eezD-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5eezD-3greA:
undetectable
5eezE-3greA:
undetectable
5eezD-3greA:
12.01
5eezE-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5eezE-3greA:
undetectable
5eezF-3greA:
undetectable
5eezE-3greA:
12.01
5eezF-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5eezJ-3greA:
undetectable
5eezK-3greA:
undetectable
5eezJ-3greA:
12.01
5eezK-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5ef0C-3greA:
undetectable
5ef0D-3greA:
undetectable
5ef0C-3greA:
12.01
5ef0D-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5ef0D-3greA:
undetectable
5ef0E-3greA:
undetectable
5ef0D-3greA:
12.01
5ef0E-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5ef0E-3greA:
undetectable
5ef0F-3greA:
undetectable
5ef0E-3greA:
12.01
5ef0F-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5ef0J-3greA:
undetectable
5ef0K-3greA:
undetectable
5ef0J-3greA:
12.01
5ef0K-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5ef1C-3greA:
undetectable
5ef1D-3greA:
undetectable
5ef1C-3greA:
12.01
5ef1D-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5ef1D-3greA:
undetectable
5ef1E-3greA:
undetectable
5ef1D-3greA:
12.01
5ef1E-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5ef1E-3greA:
undetectable
5ef1F-3greA:
undetectable
5ef1E-3greA:
12.01
5ef1F-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5ef1J-3greA:
undetectable
5ef1K-3greA:
undetectable
5ef1J-3greA:
12.01
5ef1K-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5ef2C-3greA:
undetectable
5ef2D-3greA:
undetectable
5ef2C-3greA:
12.01
5ef2D-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5ef2D-3greA:
undetectable
5ef2E-3greA:
undetectable
5ef2D-3greA:
12.01
5ef2E-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5ef2E-3greA:
undetectable
5ef2F-3greA:
undetectable
5ef2E-3greA:
12.01
5ef2F-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5ef2J-3greA:
undetectable
5ef2K-3greA:
undetectable
5ef2J-3greA:
12.01
5ef2K-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.30A 5ef3C-3greA:
undetectable
5ef3D-3greA:
undetectable
5ef3C-3greA:
12.01
5ef3D-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 10 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.33A 5ef3D-3greA:
undetectable
5ef3E-3greA:
undetectable
5ef3D-3greA:
12.01
5ef3E-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.32A 5ef3E-3greA:
undetectable
5ef3F-3greA:
undetectable
5ef3E-3greA:
12.01
5ef3F-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
5 / 9 SER A1429
ALA A1443
THR A1351
HIS A1279
ILE A1369
None
1.31A 5ef3J-3greA:
undetectable
5ef3K-3greA:
undetectable
5ef3J-3greA:
12.01
5ef3K-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
4 / 6 PHE A1214
ARG A1175
LEU A1202
ALA A1204
None
1.06A 6b89B-3greA:
undetectable
6b89B-3greA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
4 / 7 PHE A1214
ARG A1175
LEU A1202
ALA A1204
None
1.09A 6b89A-3greA:
undetectable
6b89A-3greA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae)
4 / 6 ASN A1375
LEU A1377
SER A1380
PHE A1316
None
1.21A 6ekuA-3greA:
9.8
6ekuA-3greA:
20.46