SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3grf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		4 / 6 SER A 169
GLY A 167
LEU A 259
GLU A 253
 None
 1.02A 1fduD-3grfA:
3.6		 1fduD-3grfA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 ALA A  14
ILE A  12
VAL A 316
ALA A 315
MET A 142
 None
 1.09A 1uduB-3grfA:
undetectable		 1uduB-3grfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 GLY A 219
GLY A 218
GLY A 216
PHE A 141
SER A 220
 None
 1.08A 1wg8A-3grfA:
7.0		 1wg8A-3grfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ASP A 235
PHE A 148
ARG A 275
 None
 0.67A 2a3aA-3grfA:
undetectable		 2a3aA-3grfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		4 / 6 GLU A 187
ASP A 235
PHE A 148
ARG A 275
 None
 1.16A 2a3bB-3grfA:
undetectable		 2a3bB-3grfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.79A 2nmzA-3grfA:
undetectable		 2nmzA-3grfA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.75A 2nnkA-3grfA:
undetectable		 2nnkA-3grfA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 THR A  11
SER A  13
PHE A 141
 None
 0.74A 3d4sA-3grfA:
undetectable		 3d4sA-3grfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.73A 3k4vA-3grfA:
undetectable		 3k4vA-3grfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.78A 3k4vD-3grfA:
undetectable		 3k4vD-3grfA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 TYR A  74
ILE A 125
PHE A 320
ALA A 105
ILE A 102
 None
 1.35A 3ndiA-3grfA:
2.9		 3ndiA-3grfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.78A 3ndtA-3grfA:
undetectable		 3ndtA-3grfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.85A 3nduD-3grfA:
undetectable		 3nduD-3grfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.82A 3pwrA-3grfA:
undetectable		 3pwrA-3grfA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 ARG A 255
VAL A 264
THR A 239
 None
 0.80A 3tl9A-3grfA:
undetectable		 3tl9A-3grfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 PHE A 224
CYH A 191
HIS A 189
 None
 1.04A 3u9fF-3grfA:
undetectable		 3u9fF-3grfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 PHE A 224
CYH A 191
HIS A 189
 None
 0.94A 3u9fG-3grfA:
undetectable		 3u9fG-3grfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 PHE A 224
CYH A 191
HIS A 189
 None
 1.03A 3u9fL-3grfA:
undetectable		 3u9fL-3grfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		3 / 3 PHE A 224
CYH A 191
HIS A 189
 None
 1.01A 3u9fS-3grfA:
undetectable		 3u9fS-3grfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 ILE A 125
TYR A  22
GLU A  19
ARG A   7
ASP A 323
 None
 1.19A 4b9zA-3grfA:
undetectable		 4b9zA-3grfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 TYR A  22
LEU A  15
GLU A  19
ARG A   7
ASP A 323
 None
 1.18A 4b9zA-3grfA:
undetectable		 4b9zA-3grfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		4 / 8 SER A  13
ARG A 179
GLU A 210
ILE A 211
 None
 1.01A 4d39A-3grfA:
undetectable		 4d39A-3grfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		4 / 7 ILE A 277
ARG A 275
VAL A 236
ILE A 161
 None
 0.96A 4zzbC-3grfA:
undetectable
4zzbD-3grfA:
undetectable		 4zzbC-3grfA:
21.01
4zzbD-3grfA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 GLY A 219
ILE A 211
HIS A 215
GLY A 180
GLY A 157
 None
 0.72A 5d4uA-3grfA:
2.2		 5d4uA-3grfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 GLY A 219
ILE A 211
HIS A 215
GLY A 180
GLY A 157
 None
 0.72A 5d4uB-3grfA:
5.1		 5d4uB-3grfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 GLY A 219
ILE A 211
HIS A 215
GLY A 180
GLY A 157
 None
 0.71A 5d4uC-3grfA:
3.8		 5d4uC-3grfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 GLY A 219
ILE A 211
HIS A 215
GLY A 180
GLY A 157
 None
 0.69A 5d4uD-3grfA:
5.5		 5d4uD-3grfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 12 LEU A  61
ALA A 127
PRO A 134
LEU A  15
LEU A  23
 None
 1.00A 5ljeA-3grfA:
undetectable		 5ljeA-3grfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 9 ALA A 150
PHE A 158
GLY A 157
PHE A 154
GLY A 152
 None
 1.37A 6awoA-3grfA:
undetectable		 6awoA-3grfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3grf ORNITHINE
CARBAMOYLTRANSFERASE
(Giardia
intestinalis) 		5 / 9 ALA A 150
PHE A 158
GLY A 157
PHE A 154
GLY A 152
 None
 1.37A 6awqA-3grfA:
undetectable		 6awqA-3grfA:
19.18