SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 HIS A  48
LEU A 380
LEU A  15
THR A 376
LEU A 367
 None
 1.00A 1bzfA-3griA:
undetectable		 1bzfA-3griA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 GLU A 253
THR A 255
HIS A 258
HIS A  60
 None
None
None
ZN  A 500 (-3.7A)
 1.40A 1d4fD-3griA:
undetectable		 1d4fD-3griA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 HIS A  58
HIS A 177
HIS A 230
ASP A 303
 ZN  A 500 (-3.3A)
None
ZN  A 500 ( 4.8A)
ZN  A 500 (-2.7A)
 0.58A 1e9yB-3griA:
20.6		 1e9yB-3griA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 10 GLY A 153
MET A 160
VAL A 154
ILE A 124
GLY A 151
 CL  A 600 ( 4.5A)
None
None
CL  A 600 (-4.2A)
None
 1.44A 1fohC-3griA:
undetectable		 1fohC-3griA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 10 GLY A 153
MET A 160
VAL A 154
ILE A 124
GLY A 151
 CL  A 600 ( 4.5A)
None
None
CL  A 600 (-4.2A)
None
 1.45A 1fohD-3griA:
undetectable		 1fohD-3griA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 6 HIS A  58
HIS A  60
HIS A 177
HIS A 230
ASP A 303
 ZN  A 500 (-3.3A)
ZN  A 500 (-3.7A)
None
ZN  A 500 ( 4.8A)
ZN  A 500 (-2.7A)
 0.64A 1fweC-3griA:
21.5		 1fweC-3griA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 SER A 158
THR A 156
GLU A 162
GLY A 163
 None
 0.98A 1icrA-3griA:
undetectable
1icrB-3griA:
undetectable		 1icrA-3griA:
20.71
1icrB-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 GLU A 162
GLY A 163
SER A 158
THR A 156
 None
 0.99A 1icrA-3griA:
undetectable
1icrB-3griA:
undetectable		 1icrA-3griA:
20.71
1icrB-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 SER A 158
THR A 156
GLU A 162
GLY A 163
 None
 0.98A 1icuA-3griA:
undetectable
1icuB-3griA:
undetectable		 1icuA-3griA:
20.71
1icuB-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 GLU A 162
GLY A 163
SER A 158
THR A 156
 None
 0.99A 1icuA-3griA:
undetectable
1icuB-3griA:
undetectable		 1icuA-3griA:
20.71
1icuB-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 SER A 158
THR A 156
GLU A 162
GLY A 163
 None
 0.94A 1icuC-3griA:
undetectable
1icuD-3griA:
undetectable		 1icuC-3griA:
20.71
1icuD-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 SER A 158
THR A 156
GLU A 162
GLY A 163
 None
 1.00A 1icvC-3griA:
undetectable
1icvD-3griA:
undetectable		 1icvC-3griA:
20.71
1icvD-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 GLU A 162
GLY A 163
SER A 158
THR A 156
 None
 1.01A 1icvC-3griA:
undetectable
1icvD-3griA:
undetectable		 1icvC-3griA:
20.71
1icvD-3griA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 SER A 158
THR A 156
GLU A 162
GLY A 163
 None
 1.00A 1kqbA-3griA:
undetectable
1kqbB-3griA:
undetectable		 1kqbA-3griA:
19.76
1kqbB-3griA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 GLU A 162
GLY A 163
SER A 158
THR A 156
 None
 1.01A 1kqbA-3griA:
undetectable
1kqbB-3griA:
undetectable		 1kqbA-3griA:
19.76
1kqbB-3griA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 SER A 158
THR A 156
GLU A 162
GLY A 163
 None
 1.00A 1kqbC-3griA:
undetectable
1kqbD-3griA:
undetectable		 1kqbC-3griA:
19.76
1kqbD-3griA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 GLU A 162
GLY A 163
SER A 158
THR A 156
 None
 0.98A 1kqbC-3griA:
undetectable
1kqbD-3griA:
undetectable		 1kqbC-3griA:
19.76
1kqbD-3griA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 PHE A  84
ILE A 354
GLY A 365
GLY A  53
THR A 366
 None
None
None
CL  A 601 ( 4.6A)
None
 1.06A 1nv8A-3griA:
undetectable		 1nv8A-3griA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		3 / 3 ASP A 303
HIS A 230
HIS A  58
 ZN  A 500 (-2.7A)
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.3A)
 0.68A 1oe1A-3griA:
undetectable		 1oe1A-3griA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		3 / 3 ASP A 303
HIS A 230
HIS A  58
 ZN  A 500 (-2.7A)
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.3A)
 0.68A 1oe3A-3griA:
undetectable		 1oe3A-3griA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 10 GLY A 153
MET A 160
VAL A 154
ILE A 124
GLY A 151
 CL  A 600 ( 4.5A)
None
None
CL  A 600 (-4.2A)
None
 1.46A 1pn0C-3griA:
undetectable		 1pn0C-3griA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 10 GLY A 153
MET A 160
VAL A 154
ILE A 124
GLY A 151
 CL  A 600 ( 4.5A)
None
None
CL  A 600 (-4.2A)
None
 1.46A 1pn0D-3griA:
undetectable		 1pn0D-3griA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 4 GLY A  75
SER A 326
VAL A 116
LEU A  61
 None
 1.22A 1yajB-3griA:
undetectable		 1yajB-3griA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 ARG A 309
GLU A 311
PRO A 320
ALA A 271
 None
 1.18A 2ejfB-3griA:
undetectable		 2ejfB-3griA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 7 ARG A 309
GLU A 311
PRO A 320
ALA A 271
 None
 1.25A 2ejgA-3griA:
undetectable		 2ejgA-3griA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 11 LEU A 259
LEU A 333
MET A 275
THR A 328
PRO A 399
 None
 1.34A 2x7hA-3griA:
undetectable
2x7hB-3griA:
undetectable		 2x7hA-3griA:
22.54
2x7hB-3griA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		3 / 3 ASP A 303
HIS A 230
HIS A  58
 ZN  A 500 (-2.7A)
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.3A)
 0.70A 2xxgA-3griA:
undetectable		 2xxgA-3griA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		3 / 3 ASP A 303
HIS A 230
HIS A  58
 ZN  A 500 (-2.7A)
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.3A)
 0.71A 2xxgC-3griA:
undetectable		 2xxgC-3griA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 129
GLY A 153
GLN A 155
MET A 159
VAL A  96
 None
CL  A 600 ( 4.5A)
None
None
None
 1.45A 3gn8B-3griA:
undetectable		 3gn8B-3griA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		6 / 12 LEU A 392
GLU A  73
GLY A  75
ILE A 110
LEU A  61
ASP A 111
 None
 1.41A 3gryA-3griA:
undetectable		 3gryA-3griA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 PHE A  49
GLY A  53
SER A  51
PHE A  84
ASP A  56
 None
CL  A 601 ( 4.6A)
None
None
None
 1.25A 3iv6B-3griA:
undetectable		 3iv6B-3griA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 ARG A 280
THR A 233
ASP A 284
GLU A 235
 None
 1.13A 3v5vC-3griA:
undetectable
3v5vD-3griA:
0.7		 3v5vC-3griA:
23.95
3v5vD-3griA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 9 HIS A 177
ASP A 150
HIS A 230
ASN A 276
HIS A  60
 None
ZN  A 500 ( 4.5A)
ZN  A 500 ( 4.8A)
None
ZN  A 500 (-3.7A)
 1.05A 4c1dA-3griA:
undetectable		 4c1dA-3griA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 10 HIS A 177
ASP A 150
HIS A 230
ASN A 276
HIS A  60
 None
ZN  A 500 ( 4.5A)
ZN  A 500 ( 4.8A)
None
ZN  A 500 (-3.7A)
 1.04A 4c1dB-3griA:
undetectable		 4c1dB-3griA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 GLU A 235
ARG A 280
THR A 233
ASP A 284
 None
 1.14A 4e7cA-3griA:
1.1
4e7cB-3griA:
1.2		 4e7cA-3griA:
23.95
4e7cB-3griA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 8 ASP A 150
HIS A 230
ASN A 276
HIS A  60
 ZN  A 500 ( 4.5A)
ZN  A 500 ( 4.8A)
None
ZN  A 500 (-3.7A)
 0.87A 4exsB-3griA:
undetectable		 4exsB-3griA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 HIS A  58
HIS A 177
HIS A 230
ASP A 303
 ZN  A 500 (-3.3A)
None
ZN  A 500 ( 4.8A)
ZN  A 500 (-2.7A)
 0.62A 4h9mA-3griA:
22.3		 4h9mA-3griA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 259
GLU A 253
VAL A 254
PHE A  84
GLY A 365
 None
 1.15A 4hvcB-3griA:
undetectable		 4hvcB-3griA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 ARG A 285
THR A 262
THR A 282
ASP A 264
 None
 1.37A 4oltA-3griA:
undetectable		 4oltA-3griA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 ARG A 285
THR A 262
THR A 282
ASP A 264
 None
 1.39A 4oltB-3griA:
undetectable		 4oltB-3griA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 143
GLN A 107
ALA A 144
PHE A 103
ILE A 110
 None
 1.35A 4pb1A-3griA:
undetectable		 4pb1A-3griA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 ARG A 285
THR A 262
THR A 282
ASP A 264
 None
 1.40A 4qwpA-3griA:
undetectable		 4qwpA-3griA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 ARG A 285
THR A 262
THR A 282
ASP A 264
 None
 1.37A 4qwpB-3griA:
undetectable		 4qwpB-3griA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 HIS A 190
ILE A 206
GLU A 235
ASP A 284
SER A 281
 None
 1.02A 4r88D-3griA:
23.0		 4r88D-3griA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 6 HIS A  58
HIS A  60
HIS A 177
HIS A 230
ASP A 303
 ZN  A 500 (-3.3A)
ZN  A 500 (-3.7A)
None
ZN  A 500 ( 4.8A)
ZN  A 500 (-2.7A)
 0.45A 4ubpC-3griA:
22.3		 4ubpC-3griA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 8 LEU A 375
ALA A 373
ILE A  27
ALA A  45
 None
 0.70A 4wboB-3griA:
undetectable		 4wboB-3griA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 259
GLU A 253
VAL A 254
PHE A  84
GLY A 365
 None
 1.19A 4ydqA-3griA:
undetectable		 4ydqA-3griA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 7 LYS A 404
TYR A 406
TYR A 334
LEU A 333
 None
 1.18A 4yv5A-3griA:
undetectable		 4yv5A-3griA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 8 HIS A 177
ASP A 150
HIS A 230
ASN A 276
HIS A  60
 None
ZN  A 500 ( 4.5A)
ZN  A 500 ( 4.8A)
None
ZN  A 500 (-3.7A)
 1.21A 5a5zA-3griA:
undetectable		 5a5zA-3griA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 6 LEU A 348
LEU A  10
PHE A 330
LEU A 380
 None
 0.78A 5gs4A-3griA:
undetectable		 5gs4A-3griA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 LEU A 348
LEU A  10
PHE A 330
LEU A 380
 None
 0.98A 5gtrA-3griA:
undetectable		 5gtrA-3griA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SVL_A_ACTA411_0
(P2X PURINOCEPTOR 3)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 GLN A 211
VAL A 152
ASP A 149
ASN A 181
 None
 1.34A 5svlA-3griA:
undetectable		 5svlA-3griA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 ALA A 329
VAL A 338
LEU A 352
LEU A  10
LEU A 345
 None
 1.36A 5x23A-3griA:
undetectable		 5x23A-3griA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 8 HIS A 177
ASP A 150
HIS A 230
HIS A  60
 None
ZN  A 500 ( 4.5A)
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.7A)
 1.04A 5zj8A-3griA:
undetectable		 5zj8A-3griA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 422
GLY A 325
ASN A 408
PRO A 256
ARG A  81
 None
 0.89A 6gngB-3griA:
2.1		 6gngB-3griA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3gri DIHYDROOROTASE
(Staphylococcus
aureus) 		4 / 5 LEU A 332
THR A 328
THR A 302
GLY A 325
 None
 1.19A 6gtqA-3griA:
0.5		 6gtqA-3griA:
18.46