SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gs6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 7 THR A 176
HIS A 207
SER A 219
LEU A 225
 None
 1.11A 1ibgL-3gs6A:
undetectable		 1ibgL-3gs6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 7 ALA A 218
TYR A 223
ILE A 184
PRO A 163
 None
 0.89A 1oniA-3gs6A:
undetectable
1oniB-3gs6A:
undetectable		 1oniA-3gs6A:
18.24
1oniB-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 ALA A 218
TYR A 223
ILE A 184
PRO A 163
 None
 0.89A 1oniB-3gs6A:
undetectable
1oniC-3gs6A:
undetectable		 1oniB-3gs6A:
18.24
1oniC-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 7 TYR A 223
ILE A 184
PRO A 163
ALA A 218
 None
 0.87A 1oniD-3gs6A:
undetectable
1oniE-3gs6A:
undetectable		 1oniD-3gs6A:
18.24
1oniE-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 ALA A 218
TYR A 223
ILE A 184
PRO A 163
 None
 0.94A 1oniH-3gs6A:
undetectable
1oniI-3gs6A:
undetectable		 1oniH-3gs6A:
18.24
1oniI-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 PHE A 162
ALA A 218
TYR A 223
ILE A 184
 None
 1.22A 1oniH-3gs6A:
undetectable
1oniI-3gs6A:
undetectable		 1oniH-3gs6A:
18.24
1oniI-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 7 TYR A 223
ILE A 184
PRO A 163
ALA A 218
 None
 0.91A 1oniG-3gs6A:
undetectable
1oniI-3gs6A:
undetectable		 1oniG-3gs6A:
18.24
1oniI-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BUE_A_RIOA1201_0
(AAC(6')-IB)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 11 GLY A 234
GLN A 227
TYR A 223
SER A 221
TRP A 224
 None
 1.16A 2bueA-3gs6A:
0.0		 2bueA-3gs6A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 8 TYR A 210
ASP A 179
TYR A 213
TRP A 224
 None
 1.38A 2ha2A-3gs6A:
undetectable		 2ha2A-3gs6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 8 TYR A 210
ASP A 179
TYR A 213
TRP A 224
 None
 1.41A 2ha2B-3gs6A:
undetectable		 2ha2B-3gs6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 PRO A 163
HIS A 161
ASP A 243
ASP A 242
 None
NP6  A 341 (-3.6A)
NP6  A 341 ( 4.6A)
None
 1.35A 2lh8A-3gs6A:
undetectable		 2lh8A-3gs6A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		3 / 3 VAL A 280
GLU A 277
GLU A 281
 None
 0.79A 2nv4A-3gs6A:
undetectable		 2nv4A-3gs6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 TYR A  36
LEU A  45
ASN A  46
ASP A 111
 None
 1.14A 2w98A-3gs6A:
undetectable
2w98B-3gs6A:
undetectable		 2w98A-3gs6A:
22.33
2w98B-3gs6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 HIS A 108
PHE A  71
GLN A  63
LEU A 105
 None
 1.09A 3bgdA-3gs6A:
undetectable		 3bgdA-3gs6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 ILE A  59
MET A 155
ILE A 106
HIS A 108
 None
 1.14A 3eteA-3gs6A:
undetectable
3eteE-3gs6A:
undetectable		 3eteA-3gs6A:
20.70
3eteE-3gs6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 5 ILE A  59
MET A 155
ILE A 106
HIS A 108
 None
 1.16A 3eteB-3gs6A:
undetectable
3eteC-3gs6A:
undetectable		 3eteB-3gs6A:
20.70
3eteC-3gs6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 7 MET A 155
ILE A 106
HIS A 108
ILE A  59
 None
 1.16A 3eteD-3gs6A:
undetectable
3eteF-3gs6A:
undetectable		 3eteD-3gs6A:
20.70
3eteF-3gs6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 8 ARG A  55
ASP A 111
VAL A  29
LEU A  21
 None
 1.07A 3jq7C-3gs6A:
2.4		 3jq7C-3gs6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		3 / 3 ARG A 258
VAL A 209
THR A 176
 None
 0.84A 3nduD-3gs6A:
undetectable		 3nduD-3gs6A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 7 GLY A 121
ASP A 119
GLY A 166
HIS A 161
 None
None
None
NP6  A 341 (-3.6A)
 0.93A 4c5nA-3gs6A:
2.3		 4c5nA-3gs6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  98
ALA A 102
ALA A 152
VAL A 153
ALA A 145
 None
None
None
GOL  A 342 (-4.5A)
None
 1.29A 4df3A-3gs6A:
undetectable		 4df3A-3gs6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  98
ALA A 102
VAL A 153
ALA A 145
GLN A  96
 None
None
GOL  A 342 (-4.5A)
None
None
 1.37A 4df3A-3gs6A:
undetectable		 4df3A-3gs6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  98
ALA A 102
ALA A 152
VAL A 153
ALA A 145
 None
None
None
GOL  A 342 (-4.5A)
None
 1.29A 4df3B-3gs6A:
undetectable		 4df3B-3gs6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.07A 4fp9A-3gs6A:
undetectable		 4fp9A-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.07A 4fp9C-3gs6A:
undetectable		 4fp9C-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.08A 4fp9D-3gs6A:
undetectable		 4fp9D-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.07A 4fp9F-3gs6A:
undetectable		 4fp9F-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		3 / 3 ARG A 313
GLN A  96
GLU A  95
 None
 0.83A 4tvtA-3gs6A:
undetectable		 4tvtA-3gs6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 4 LEU A  58
ILE A  59
GLY A  27
ILE A  49
 None
 0.87A 5dzk3-3gs6A:
undetectable
5dzkm-3gs6A:
undetectable		 5dzk3-3gs6A:
4.65
5dzkm-3gs6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 5 ILE A  59
GLY A  27
ILE A  49
LEU A  58
 None
 0.93A 5dzkd-3gs6A:
2.8
5dzkk-3gs6A:
undetectable
5dzky-3gs6A:
undetectable		 5dzkd-3gs6A:
20.47
5dzkk-3gs6A:
22.49
5dzky-3gs6A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		4 / 6 TYR A 210
ASP A 179
TYR A 213
TRP A 224
 None
 1.30A 5e2iA-3gs6A:
undetectable		 5e2iA-3gs6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 PRO A 177
SER A 219
ASP A 119
HIS A 161
GLY A 166
 None
None
None
NP6  A 341 (-3.6A)
None
 1.28A 5eenA-3gs6A:
undetectable		 5eenA-3gs6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		3 / 3 ILE A  57
MET A 155
ASP A 109
 None
 0.79A 5h2uA-3gs6A:
undetectable		 5h2uA-3gs6A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		3 / 3 VAL A  68
LEU A 200
MET A 203
 None
 0.86A 5ikrA-3gs6A:
undetectable		 5ikrA-3gs6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3gs6 BETA-HEXOSAMINIDASE
(Vibrio
cholerae) 		5 / 12 ASP A  62
PHE A 114
LYS A 160
HIS A 161
MET A 204
 NP6  A 341 (-3.0A)
None
NP6  A 341 (-3.0A)
NP6  A 341 (-3.6A)
NP6  A 341 (-3.5A)
 0.52A 5m6gA-3gs6A:
24.8		 5m6gA-3gs6A:
20.38