SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 8 GLU A 242
GLU A 247
ASP A 246
MET A 255
 None
 1.06A 1dtlA-3gs9A:
undetectable		 1dtlA-3gs9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 7 ALA A  88
PHE A  68
VAL A  70
VAL A  61
 None
 0.79A 1epbA-3gs9A:
undetectable		 1epbA-3gs9A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 12 ASP A 154
LEU A 157
ILE A 117
PHE A 118
PHE A 173
 None
 1.18A 1xmuA-3gs9A:
undetectable		 1xmuA-3gs9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 12 ASP A 154
LEU A 157
ILE A 117
PHE A 118
PHE A 173
 None
 1.25A 1xomA-3gs9A:
undetectable		 1xomA-3gs9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 5 LEU A 157
ASP A 154
PRO A 166
VAL A 164
ILE A 153
 None
 1.35A 2aoiB-3gs9A:
undetectable		 2aoiB-3gs9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 8 TYR A 266
ASP A 265
SER A 230
TYR A 228
 None
None
None
MLY  A 260 ( 3.9A)
 1.34A 2bteA-3gs9A:
undetectable		 2bteA-3gs9A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 8 TYR A 266
ASP A 265
SER A 230
TYR A 228
 None
None
None
MLY  A 260 ( 3.9A)
 1.29A 2v0gA-3gs9A:
undetectable		 2v0gA-3gs9A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 12 GLY A 106
LEU A 152
GLN A 155
ASP A 159
ASP A 246
 None
 1.42A 2vqyA-3gs9A:
undetectable		 2vqyA-3gs9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		3 / 3 CYH A 113
HIS A 116
PHE A 108
 None
 1.11A 3cr4X-3gs9A:
undetectable		 3cr4X-3gs9A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 11 LEU A 157
ASP A 154
PRO A 166
VAL A 164
ILE A 153
 None
 1.30A 3oxxB-3gs9A:
undetectable		 3oxxB-3gs9A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 5 PHE A 118
ILE A 117
GLY A  98
CYH A  95
 None
 1.21A 3r0lD-3gs9A:
undetectable		 3r0lD-3gs9A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 11 PRO A  89
SER A  37
ILE A  38
VAL A  61
ILE A  91
 None
None
OCS  A  27 ( 4.2A)
None
None
 1.21A 3rf4A-3gs9A:
undetectable
3rf4C-3gs9A:
undetectable		 3rf4A-3gs9A:
15.52
3rf4C-3gs9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 11 ILE A  91
PRO A  89
SER A  37
ILE A  38
VAL A  61
 None
None
None
OCS  A  27 ( 4.2A)
None
 1.21A 3rf4A-3gs9A:
undetectable
3rf4B-3gs9A:
undetectable		 3rf4A-3gs9A:
15.52
3rf4B-3gs9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 11 ILE A  91
PRO A  89
SER A  37
ILE A  38
VAL A  61
 None
None
None
OCS  A  27 ( 4.2A)
None
 1.23A 3rf4B-3gs9A:
undetectable
3rf4C-3gs9A:
undetectable		 3rf4B-3gs9A:
15.52
3rf4C-3gs9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 7 LEU A  18
VAL A  61
VAL A  42
ASP A  56
 None
None
MLY  A  41 ( 3.0A)
None
 0.93A 3rgfA-3gs9A:
undetectable		 3rgfA-3gs9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 5 ILE A 200
THR A 269
THR A 270
PHE A 289
 None
 0.78A 3snfA-3gs9A:
undetectable		 3snfA-3gs9A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 11 PHE A  26
LEU A  18
ILE A   6
PHE A 310
ILE A  86
 OCS  A  27 ( 4.1A)
None
None
None
None
 1.14A 4dm8A-3gs9A:
undetectable		 4dm8A-3gs9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 7 ASP A 121
ARG A 123
GLY A 124
THR A  94
 None
 0.92A 5btgA-3gs9A:
undetectable
5btgC-3gs9A:
undetectable
5btgD-3gs9A:
undetectable		 5btgA-3gs9A:
20.20
5btgC-3gs9A:
20.20
5btgD-3gs9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		3 / 3 LEU A 152
PHE A 118
ILE A 153
 None
 0.73A 5dzk1-3gs9A:
undetectable
5dzkF-3gs9A:
undetectable
5dzkM-3gs9A:
undetectable		 5dzk1-3gs9A:
1.27
5dzkF-3gs9A:
21.70
5dzkM-3gs9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 12 LEU A  82
SER A  59
VAL A  70
ILE A  86
ASP A  85
 None
None
None
None
MLY  A  41 ( 3.9A)
 1.23A 6bxmA-3gs9A:
undetectable		 6bxmA-3gs9A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		5 / 12 LEU A  82
SER A  59
VAL A  70
ILE A  86
ASP A  85
 None
None
None
None
MLY  A  41 ( 3.9A)
 1.28A 6bxnA-3gs9A:
undetectable		 6bxnA-3gs9A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3gs9 PROTEIN GP18
(Listeria
monocytogenes) 		4 / 8 ILE A  17
VAL A  69
LYS A  71
GLU A  67
 None
None
None
MLY  A  12 ( 3.6A)
 1.14A 6fbvC-3gs9A:
undetectable		 6fbvC-3gs9A:
15.45