SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gse'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.56A 1i7qA-3gseA:
32.9		 1i7qA-3gseA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 10 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.47A 1i7qC-3gseA:
32.9		 1i7qC-3gseA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 HIS A 241
SER A 232
ARG A 233
LEU A 445
 None
 1.04A 1ibgL-3gseA:
undetectable		 1ibgL-3gseA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 VAL A 307
LEU A 337
PRO A 326
ASP A 308
 None
 0.63A 2ddwA-3gseA:
undetectable		 2ddwA-3gseA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		6 / 11 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
LEU A 404
 None
 0.79A 2fn1A-3gseA:
35.5		 2fn1A-3gseA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.55A 2fn1B-3gseA:
35.3		 2fn1B-3gseA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ILE A 201
PHE A 374
ALA A 370
ALA A 361
GLU A 302
 None
 0.91A 2j0dA-3gseA:
undetectable		 2j0dA-3gseA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 ALA A 403
SER A 406
ALA A 387
GLY A 388
PHE A 100
 None
 1.50A 2xfsB-3gseA:
undetectable		 2xfsB-3gseA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 9 GLU A 258
ARG A 313
VAL A 307
ALA A 362
ALA A 361
 None
 1.30A 3ax7B-3gseA:
undetectable		 3ax7B-3gseA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 PHE A 161
LEU A 130
LEU A  11
LEU A 143
 None
 0.91A 3bgdB-3gseA:
3.2		 3bgdB-3gseA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 SER A 123
GLN A 121
PHE A 124
 None
 0.69A 3g4lC-3gseA:
undetectable		 3g4lC-3gseA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 LEU A   8
GLY A   9
LEU A  11
ARG A  12
ASP A 163
 None
 1.01A 3gwwA-3gseA:
undetectable		 3gwwA-3gseA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 THR A 139
ALA A  32
LEU A   4
LEU A   7
LEU A  11
 None
 1.14A 3hm1A-3gseA:
undetectable		 3hm1A-3gseA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 LEU A 331
ARG A 259
ASN A 303
 None
SO4  A 456 (-3.0A)
None
 0.75A 3qxvD-3gseA:
undetectable		 3qxvD-3gseA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.28A 3r75A-3gseA:
3.7		 3r75A-3gseA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.29A 3r75B-3gseA:
34.4		 3r75B-3gseA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.29A 3r76A-3gseA:
35.2		 3r76A-3gseA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.30A 3r76B-3gseA:
34.5		 3r76B-3gseA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 LEU A  41
SER A 255
LEU A 253
SER A 444
 None
 0.92A 3r9vA-3gseA:
undetectable
3r9vB-3gseA:
undetectable		 3r9vA-3gseA:
20.17
3r9vB-3gseA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 TYR A 261
LEU A 393
ALA A  79
SER A 123
 None
 1.11A 3rodA-3gseA:
undetectable		 3rodA-3gseA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 TYR A 240
HIS A  57
ARG A  58
 None
SO4  A 456 (-4.7A)
SO4  A 456 (-3.9A)
 1.06A 4e7bC-3gseA:
undetectable		 4e7bC-3gseA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 LEU A 130
GLU A  10
LEU A  11
ALA A  32
LEU A 141
 None
 1.02A 4wg0B-3gseA:
undetectable
4wg0C-3gseA:
undetectable
4wg0D-3gseA:
undetectable		 4wg0B-3gseA:
4.18
4wg0C-3gseA:
4.18
4wg0D-3gseA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 LEU A 130
GLU A  10
LEU A  11
ALA A  32
LEU A 141
 None
 1.00A 4wg0D-3gseA:
undetectable
4wg0E-3gseA:
undetectable
4wg0F-3gseA:
undetectable		 4wg0D-3gseA:
4.18
4wg0E-3gseA:
4.18
4wg0F-3gseA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 ALA A  32
LEU A 141
GLU A  10
LEU A  11
LEU A 130
 None
 1.04A 4wg0G-3gseA:
undetectable
4wg0H-3gseA:
undetectable
4wg0I-3gseA:
undetectable		 4wg0G-3gseA:
4.18
4wg0H-3gseA:
4.18
4wg0I-3gseA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 LEU A 130
GLU A  10
LEU A  11
ALA A  32
LEU A 141
 None
 1.02A 4wg0J-3gseA:
undetectable
4wg0K-3gseA:
undetectable
4wg0L-3gseA:
undetectable		 4wg0J-3gseA:
4.18
4wg0K-3gseA:
4.18
4wg0L-3gseA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 ALA A  32
LEU A 141
GLU A  10
LEU A  11
LEU A 130
 None
 1.01A 4wg0I-3gseA:
undetectable
4wg0J-3gseA:
undetectable
4wg0K-3gseA:
undetectable		 4wg0I-3gseA:
4.18
4wg0J-3gseA:
4.18
4wg0K-3gseA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 LEU A 253
VAL A 409
ILE A 414
ASN A 236
LEU A 445
 None
 1.35A 4yvpB-3gseA:
undetectable		 4yvpB-3gseA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 TYR A 261
ASP A 350
ILE A  83
ILE A  94
PHE A 400
 None
 1.30A 5hw8B-3gseA:
undetectable		 5hw8B-3gseA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 LYS A 208
GLN A 300
ASN A 303
 None
 0.93A 5l2tA-3gseA:
undetectable		 5l2tA-3gseA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 ARG A 134
THR A 139
GLN A  39
GLY A  34
 None
 0.69A 5nzyA-3gseA:
undetectable		 5nzyA-3gseA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 6 TRP A  95
LEU A 244
PRO A  51
SER A  72
 None
 1.35A 5syjA-3gseA:
undetectable		 5syjA-3gseA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 6 TRP A  95
LEU A 244
PRO A  51
SER A  72
 None
 1.36A 5syjB-3gseA:
undetectable		 5syjB-3gseA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 5 ARG A 129
LEU A 143
PHE A  30
LEU A 145
 None
None
SO4  A 457 ( 4.6A)
None
 1.21A 5x1fC-3gseA:
undetectable
5x1fJ-3gseA:
undetectable		 5x1fC-3gseA:
18.40
5x1fJ-3gseA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 5 ARG A 129
LEU A 143
PHE A  30
LEU A 145
 None
None
SO4  A 457 ( 4.6A)
None
 1.22A 5xdxC-3gseA:
undetectable
5xdxJ-3gseA:
undetectable		 5xdxC-3gseA:
20.10
5xdxJ-3gseA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE
(Yersinia
pestis) 		4 / 5 ARG A 129
LEU A 143
PHE A  30
LEU A 145
 None
None
SO4  A 457 ( 4.6A)
None
 1.27A 5xdxP-3gseA:
undetectable
5xdxW-3gseA:
undetectable		 5xdxP-3gseA:
20.10
5xdxW-3gseA:
9.11