SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 4 LYS A 509
LEU A 511
ALA A 567
LEU A 565
None
1.28A 1f86B-3gsiA:
undetectable
1f86B-3gsiA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 7 VAL A 360
THR A 338
LEU A 220
VAL A 356
None
0.87A 1jgsA-3gsiA:
undetectable
1jgsA-3gsiA:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ5_A_ACTA2145_0
(N,N-DIMETHYLGLYCINE
OXIDASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 5 ARG A 252
TYR A 259
TYR A 272
TRP A 361
TYR A 415
None
FAD  A 902 (-4.8A)
None
None
None
0.83A 1pj5A-3gsiA:
72.5
1pj5A-3gsiA:
99.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ6_A_FOLA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
8 / 9 LEU A 508
TYR A 539
THR A 554
TYR A 631
PHE A 632
LEU A 649
GLU A 658
TYR A 699
THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-2.6A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-2.8A)
THG  A2887 (-4.1A)
0.21A 1pj6A-3gsiA:
72.7
1pj6A-3gsiA:
99.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ6_A_FOLA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
6 / 9 TYR A 539
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 699
THG  A2887 (-3.9A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
THG  A2887 (-4.1A)
0.56A 1pj6A-3gsiA:
72.7
1pj6A-3gsiA:
99.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
12 / 12 MET A 505
LEU A 508
TYR A 539
GLY A 566
ASN A 568
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 660
TYR A 699
PHE A 719
None
THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-3.6A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
None
THG  A2887 (-4.1A)
THG  A2887 (-4.6A)
0.21A 1pj7A-3gsiA:
72.8
1pj7A-3gsiA:
99.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 TYR A 539
ASN A 568
TYR A 631
TYR A 651
TYR A 699
THG  A2887 (-3.9A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.3A)
THG  A2887 (-4.1A)
0.73A 1wopA-3gsiA:
47.9
1wopA-3gsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 ILE A 390
LEU A 398
ALA A 217
GLU A 350
None
1.19A 1xvaA-3gsiA:
3.2
1xvaB-3gsiA:
3.1
1xvaA-3gsiA:
17.72
1xvaB-3gsiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 11 VAL A 555
ILE A 553
LEU A 565
ILE A 729
PHE A 576
None
1.11A 2dg9A-3gsiA:
undetectable
2dg9A-3gsiA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 MET A 723
ALA A 720
LEU A 717
GLY A 548
LEU A 543
None
1.09A 2jfaB-3gsiA:
undetectable
2jfaB-3gsiA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 7 PRO A  42
GLY A  13
ILE A   9
GLY A  11
FAD  A 902 (-4.8A)
FAD  A 902 (-3.1A)
None
FAD  A 902 (-3.2A)
0.87A 2jklC-3gsiA:
undetectable
2jklC-3gsiA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
6 / 12 SER A 201
ALA A 359
GLY A 204
ALA A 203
VAL A 403
LEU A 398
None
None
FAD  A 902 (-3.4A)
FAD  A 902 (-3.8A)
None
None
1.26A 2nyuA-3gsiA:
3.8
2nyuA-3gsiA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 6 TYR A 227
TYR A 267
TYR A 259
ILE A 250
None
None
FAD  A 902 (-4.8A)
None
1.47A 2pgzD-3gsiA:
undetectable
2pgzE-3gsiA:
undetectable
2pgzD-3gsiA:
13.14
2pgzE-3gsiA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 8 VAL A 774
THR A 704
SER A 701
ARG A 694
None
0.75A 2v32C-3gsiA:
undetectable
2v32D-3gsiA:
undetectable
2v32C-3gsiA:
14.87
2v32D-3gsiA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 8 SER A 407
ASN A 410
ASP A 340
ARG A 392
None
0.95A 2v57A-3gsiA:
undetectable
2v57A-3gsiA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 8 SER A 407
ASN A 410
ASP A 340
ARG A 392
None
0.95A 2v57C-3gsiA:
undetectable
2v57C-3gsiA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
6 / 12 GLY A  16
GLY A  11
LEU A  19
ALA A 357
ALA A 369
VAL A 154
None
FAD  A 902 (-3.2A)
None
None
None
None
1.17A 2yqzA-3gsiA:
undetectable
2yqzA-3gsiA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
6 / 12 GLY A  16
GLY A  11
LEU A  19
ALA A 357
ALA A 369
VAL A 154
None
FAD  A 902 (-3.2A)
None
None
None
None
1.17A 2yqzB-3gsiA:
undetectable
2yqzB-3gsiA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
3 / 3 LEU A 629
TRP A 608
TYR A 631
None
0.83A 3aicH-3gsiA:
undetectable
3aicH-3gsiA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 8 VAL A 154
GLY A  44
THR A  46
PHE A 205
GLY A 204
None
FAD  A 902 (-3.4A)
FAD  A 902 (-3.4A)
None
FAD  A 902 (-3.4A)
1.48A 3aruA-3gsiA:
undetectable
3aruA-3gsiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
3 / 3 LEU A 140
LEU A 102
ARG A 104
None
0.74A 3hcnB-3gsiA:
undetectable
3hcnB-3gsiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 9 VAL A 619
TRP A 670
GLN A 667
VAL A 644
GLY A 640
None
1.32A 3km6B-3gsiA:
undetectable
3km6B-3gsiA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
3 / 3 ARG A 477
ILE A 488
TRP A 457
None
1.08A 3nw2A-3gsiA:
undetectable
3nw2A-3gsiA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 GLU A 358
GLY A 207
ALA A 208
SER A 348
CYH A 388
None
1.42A 3s8pB-3gsiA:
undetectable
3s8pB-3gsiA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 6 ASN A  57
PHE A  65
ALA A  66
THR A  69
None
0.86A 3t3sB-3gsiA:
undetectable
3t3sB-3gsiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 8 ASN A  57
PHE A  65
ALA A  66
THR A  69
None
0.84A 3t3sD-3gsiA:
undetectable
3t3sD-3gsiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 ASP A 145
VAL A 362
ILE A  14
ASN A  18
LEU A  74
None
FAD  A 902 (-3.7A)
FAD  A 902 (-4.8A)
None
None
1.10A 4a84A-3gsiA:
undetectable
4a84A-3gsiA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 8 ILE A 804
ASP A 803
ILE A 811
GLY A 754
None
0.67A 4acaC-3gsiA:
4.3
4acaC-3gsiA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 8 ILE A 804
ASP A 803
ILE A 811
GLY A 754
None
0.70A 4acbC-3gsiA:
4.2
4acbC-3gsiA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 HIS A 225
TRP A 361
LEU A 147
ASP A 145
FAD  A 902 (-4.3A)
None
None
None
1.09A 4aqlA-3gsiA:
undetectable
4aqlA-3gsiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 GLU A 358
GLY A 207
ALA A 208
SER A 348
CYH A 388
None
1.41A 4bupA-3gsiA:
undetectable
4bupA-3gsiA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 6 PRO A  50
TYR A 259
TYR A 272
PHE A 335
FAD  A 902 (-3.7A)
FAD  A 902 (-4.8A)
None
FAD  A 902 (-3.8A)
1.00A 4g10A-3gsiA:
undetectable
4g10A-3gsiA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 LEU A 157
ALA A 373
ILE A  14
GLY A  16
GLY A  11
None
None
FAD  A 902 (-4.8A)
None
FAD  A 902 (-3.2A)
0.97A 4hfpB-3gsiA:
undetectable
4hfpB-3gsiA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 VAL A 368
MET A 372
GLU A 374
LEU A 385
None
0.75A 4hojA-3gsiA:
undetectable
4hojA-3gsiA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 4 ASP A 389
LEU A 385
ARG A 380
THR A 391
None
1.49A 4kjjA-3gsiA:
undetectable
4kjjA-3gsiA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 4 ASP A 389
LEU A 385
ARG A 380
THR A 391
None
1.43A 4kjkA-3gsiA:
undetectable
4kjkA-3gsiA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 TYR A 660
ARG A 510
ASP A 597
VAL A 593
None
1.44A 4nkvB-3gsiA:
undetectable
4nkvB-3gsiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 LEU A 284
GLY A 285
VAL A 292
MET A 297
THR A 173
None
None
None
None
FAD  A 902 ( 4.5A)
1.26A 4okbA-3gsiA:
undetectable
4okbA-3gsiA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 ASP A 389
LEU A 385
ARG A 380
THR A 391
None
1.43A 4p3qA-3gsiA:
undetectable
4p3qA-3gsiA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 10 ALA A 148
ALA A 153
ALA A 150
VAL A  53
THR A  69
None
1.04A 4qvyK-3gsiA:
undetectable
4qvyL-3gsiA:
undetectable
4qvyK-3gsiA:
13.30
4qvyL-3gsiA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 10 ALA A 148
ALA A 153
ALA A 150
VAL A  53
THR A  69
None
1.03A 4qvyY-3gsiA:
undetectable
4qvyZ-3gsiA:
undetectable
4qvyY-3gsiA:
13.30
4qvyZ-3gsiA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 ILE A 194
VAL A   8
ILE A  10
VAL A 187
None
0.59A 4xdtA-3gsiA:
undetectable
4xdtA-3gsiA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 5 ALA A 574
ARG A 550
HIS A 582
ALA A 579
None
1.41A 5a06C-3gsiA:
4.1
5a06D-3gsiA:
undetectable
5a06C-3gsiA:
18.16
5a06D-3gsiA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 9 LYS A 103
LEU A 102
LEU A 119
GLY A 139
LEU A 140
None
1.13A 5dqfA-3gsiA:
undetectable
5dqfA-3gsiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
3 / 3 TRP A 657
ILE A 639
SER A 620
None
0.76A 5gqbA-3gsiA:
undetectable
5gqbA-3gsiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 10 ILE A  10
ILE A 210
VAL A 199
GLU A 350
ILE A 214
None
1.12A 5lg3H-3gsiA:
undetectable
5lg3H-3gsiA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 ASP A 340
SER A  59
PHE A  65
ARG A 392
LEU A 385
None
1.47A 5m54B-3gsiA:
2.0
5m54B-3gsiA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_1
(CARNOSINE
N-METHYLTRANSFERASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 4 ARG A 424
TYR A 402
GLU A 453
ASP A 504
None
1.45A 5yf0B-3gsiA:
2.8
5yf0B-3gsiA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 9 LEU A 749
GLY A 772
LEU A 792
THR A 775
VAL A 774
None
1.13A 6czmB-3gsiA:
2.3
6czmC-3gsiA:
2.1
6czmB-3gsiA:
18.65
6czmC-3gsiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 9 LEU A 749
GLY A 772
LEU A 792
THR A 775
VAL A 774
None
1.10A 6czmD-3gsiA:
1.9
6czmE-3gsiA:
1.7
6czmD-3gsiA:
18.65
6czmE-3gsiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 10 LEU A 749
GLY A 772
LEU A 792
THR A 775
VAL A 774
None
1.12A 6czmE-3gsiA:
1.7
6czmF-3gsiA:
2.0
6czmE-3gsiA:
18.65
6czmF-3gsiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 6 VAL A  92
LEU A 131
LEU A 319
LEU A 248
None
0.93A 6f6sA-3gsiA:
undetectable
6f6sB-3gsiA:
undetectable
6f6sA-3gsiA:
8.68
6f6sB-3gsiA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
4 / 6 ARG A 392
PHE A 393
VAL A 218
PRO A 219
None
1.43A 6fgdA-3gsiA:
3.8
6fgdA-3gsiA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 10 TRP A 670
ARG A 668
ALA A 672
GLY A 666
LEU A 693
None
1.08A 6hqbA-3gsiA:
undetectable
6hqbJ-3gsiA:
undetectable
6hqbA-3gsiA:
7.05
6hqbJ-3gsiA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
5 / 12 ASP A 145
LEU A 118
LEU A 140
ILE A 114
ALA A 109
None
1.31A 6n91A-3gsiA:
undetectable
6n91A-3gsiA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis)
3 / 3 ASP A 389
LEU A 385
ARG A 380
None
0.90A 7dfrA-3gsiA:
undetectable
7dfrA-3gsiA:
11.05