SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 8 SER A  96
ALA A  97
GLY A 283
ILE A 160
 None
 0.69A 1gtnI-3gszA:
undetectable
1gtnJ-3gszA:
undetectable		 1gtnI-3gszA:
9.96
1gtnJ-3gszA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 7 LEU A  82
GLU A 248
LEU A 127
GLU A 124
 None
 1.10A 1linA-3gszA:
undetectable		 1linA-3gszA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 6 SER A 453
ASN A 455
LEU A 457
ASP A 458
 None
 1.27A 1mxdA-3gszA:
undetectable		 1mxdA-3gszA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 10 LEU A 489
LEU A 497
SER A 478
LEU A 482
ARG A 484
 None
 1.39A 2ceoB-3gszA:
undetectable		 2ceoB-3gszA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 12 PHE A 526
TRP A 500
ALA A 494
ALA A 396
THR A 399
 None
 0.97A 2ve3A-3gszA:
undetectable		 2ve3A-3gszA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 12 PHE A 526
TRP A 500
ALA A 494
ALA A 396
THR A 399
 None
 0.97A 2ve3B-3gszA:
undetectable		 2ve3B-3gszA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 ARG A 158
VAL A 284
THR A 287
 None
 0.68A 3cyxA-3gszA:
undetectable		 3cyxA-3gszA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 VAL A  52
VAL A 161
SER A 282
 None
 0.60A 3n8xB-3gszA:
undetectable		 3n8xB-3gszA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 7 SER A 190
TYR A 296
VAL A  67
TYR A 219
 None
 1.03A 3tneB-3gszA:
undetectable		 3tneB-3gszA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 6 CYH A 295
THR A 294
ASN A 291
GLY A 317
 None
 1.28A 3w9tE-3gszA:
undetectable		 3w9tE-3gszA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 5 LEU A 256
ASP A 125
GLU A 248
VAL A  85
 None
 1.33A 4nkvA-3gszA:
undetectable		 4nkvA-3gszA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.23A 4qvlV-3gszA:
undetectable
4qvlb-3gszA:
undetectable		 4qvlV-3gszA:
17.03
4qvlb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.22A 4qvlH-3gszA:
undetectable
4qvlN-3gszA:
undetectable		 4qvlH-3gszA:
17.03
4qvlN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qvmV-3gszA:
undetectable
4qvmb-3gszA:
undetectable		 4qvmV-3gszA:
17.03
4qvmb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qvmH-3gszA:
undetectable
4qvmN-3gszA:
undetectable		 4qvmH-3gszA:
17.03
4qvmN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qvpV-3gszA:
undetectable
4qvpb-3gszA:
undetectable		 4qvpV-3gszA:
17.03
4qvpb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qvpH-3gszA:
undetectable
4qvpN-3gszA:
undetectable		 4qvpH-3gszA:
17.03
4qvpN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qvqV-3gszA:
undetectable
4qvqb-3gszA:
undetectable		 4qvqV-3gszA:
17.03
4qvqb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qvqH-3gszA:
undetectable
4qvqN-3gszA:
undetectable		 4qvqH-3gszA:
17.03
4qvqN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qw0V-3gszA:
undetectable
4qw0b-3gszA:
undetectable		 4qw0V-3gszA:
17.03
4qw0b-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.23A 4qw0H-3gszA:
undetectable
4qw0N-3gszA:
undetectable		 4qw0H-3gszA:
17.03
4qw0N-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qw3V-3gszA:
undetectable
4qw3b-3gszA:
undetectable		 4qw3V-3gszA:
17.03
4qw3b-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 4qw3H-3gszA:
undetectable
4qw3N-3gszA:
undetectable		 4qw3H-3gszA:
17.03
4qw3N-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.22A 5bxnV-3gszA:
undetectable
5bxnb-3gszA:
undetectable		 5bxnV-3gszA:
17.20
5bxnb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.22A 5bxnH-3gszA:
undetectable
5bxnN-3gszA:
undetectable		 5bxnH-3gszA:
17.20
5bxnN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.22A 5cz7H-3gszA:
undetectable
5cz7N-3gszA:
undetectable		 5cz7H-3gszA:
17.03
5cz7N-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.23A 5d0xV-3gszA:
undetectable
5d0xb-3gszA:
undetectable		 5d0xV-3gszA:
17.03
5d0xb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.23A 5d0xH-3gszA:
undetectable
5d0xN-3gszA:
undetectable		 5d0xH-3gszA:
17.03
5d0xN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 6 GLU A 236
GLY A 290
ARG A 280
PHE A 224
 None
 1.05A 5jcnB-3gszA:
undetectable		 5jcnB-3gszA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A  40
SER A  39
TYR A  38
 None
 0.85A 5jsdA-3gszA:
undetectable		 5jsdA-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A  40
SER A  39
TYR A  38
 None
 0.86A 5jsdB-3gszA:
undetectable		 5jsdB-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A  40
SER A  39
TYR A  38
 None
 0.85A 5jsdC-3gszA:
undetectable		 5jsdC-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A  40
SER A  39
TYR A  38
 None
 0.87A 5jseA-3gszA:
undetectable		 5jseA-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A  40
SER A  39
TYR A  38
 None
 0.86A 5jseB-3gszA:
undetectable		 5jseB-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A  40
SER A  39
TYR A  38
 None
 0.86A 5jseC-3gszA:
undetectable		 5jseC-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.23A 5l5zV-3gszA:
undetectable
5l5zb-3gszA:
undetectable		 5l5zV-3gszA:
17.03
5l5zb-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.24A 5l5zH-3gszA:
undetectable
5l5zN-3gszA:
undetectable		 5l5zH-3gszA:
17.03
5l5zN-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.23A 5l66V-3gszA:
undetectable
5l66b-3gszA:
undetectable		 5l66V-3gszA:
17.03
5l66b-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.22A 5l66H-3gszA:
undetectable
5l66N-3gszA:
undetectable		 5l66H-3gszA:
17.03
5l66N-3gszA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.29A 5lf3b-3gszA:
undetectable		 5lf3b-3gszA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.28A 5lf3N-3gszA:
undetectable		 5lf3N-3gszA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A 385
GLU A 481
HIS A 480
 None
 0.87A 5xioA-3gszA:
undetectable		 5xioA-3gszA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		3 / 3 THR A 385
GLU A 481
HIS A 480
 None
 0.88A 5xiqD-3gszA:
undetectable		 5xiqD-3gszA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 5 LEU A 256
THR A 287
ARG A 234
ARG A 278
 None
 1.33A 6ew0B-3gszA:
undetectable		 6ew0B-3gszA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 5 LEU A 256
THR A 287
ARG A 234
ARG A 278
 None
 1.33A 6ew0D-3gszA:
undetectable		 6ew0D-3gszA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 5 LEU A 256
THR A 287
ARG A 234
ARG A 278
 None
 1.33A 6ew0H-3gszA:
undetectable		 6ew0H-3gszA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 5 LEU A 256
THR A 287
ARG A 234
ARG A 278
 None
 1.33A 6ew0I-3gszA:
undetectable		 6ew0I-3gszA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3gsz RNA-DIRECTED RNA
POLYMERASE
(Hepacivirus
C) 		4 / 8 ASP A  61
ARG A 345
VAL A  71
ARG A 280
 None
 1.12A 6fbvD-3gszA:
undetectable		 6fbvD-3gszA:
19.38