SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 11 ILE A  18
GLY A   9
ILE A   8
ILE A   5
ILE A  32
 None
 1.10A 3ebzA-3gt0A:
undetectable		 3ebzA-3gt0A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 12 GLY A   9
ILE A  18
ASP A  36
LEU A  37
ASN A  38
 None
 1.20A 3q87B-3gt0A:
3.4		 3q87B-3gt0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		4 / 8 VAL A 147
LEU A 133
ILE A  96
MET A  13
 None
 0.82A 3u5kA-3gt0A:
undetectable		 3u5kA-3gt0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		4 / 8 VAL A 147
LEU A 133
ILE A  96
MET A  13
 None
 0.80A 3u5kD-3gt0A:
undetectable		 3u5kD-3gt0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 11 ILE A 150
PHE A   7
GLY A  20
GLY A  19
TYR A  49
 None
 1.48A 4fglA-3gt0A:
undetectable
4fglB-3gt0A:
2.4		 4fglA-3gt0A:
19.92
4fglB-3gt0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 10 GLY A  20
GLY A  19
TYR A  49
ILE A 150
PHE A   7
 None
 1.45A 5lbtA-3gt0A:
4.7
5lbtB-3gt0A:
4.7		 5lbtA-3gt0A:
20.45
5lbtB-3gt0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 10 TYR A  76
ILE A  79
ILE A  80
ILE A  87
ILE A  86
 None
 0.96A 5murE-3gt0A:
undetectable		 5murE-3gt0A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 12 ILE A  18
LEU A  51
SER A  70
GLY A  14
GLY A   9
 None
 1.08A 5nnaA-3gt0A:
undetectable		 5nnaA-3gt0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 12 ILE A  18
LEU A  51
SER A  70
GLY A  14
GLY A   9
 None
 1.05A 5nnaB-3gt0A:
undetectable		 5nnaB-3gt0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 12 ILE A  18
LEU A  51
SER A  70
GLY A  14
GLY A   9
 None
 1.03A 5nnaC-3gt0A:
undetectable		 5nnaC-3gt0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		5 / 10 ILE A  18
ASP A  36
GLY A   9
PHE A   7
ALA A  40
 None
 1.27A 5x66D-3gt0A:
undetectable		 5x66D-3gt0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Bacillus
cereus) 		4 / 8 ILE A  71
ASN A  58
PHE A   7
ALA A  61
 None
 0.77A 5y7pC-3gt0A:
undetectable		 5y7pC-3gt0A:
21.78