SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 6 TRP A 171
THR A 147
GLY A 101
TYR A 103
 None
 1.05A 1gtiC-3gt5A:
2.8		 1gtiC-3gt5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 8 TYR A  68
THR A 382
TYR A  29
MET A 387
 None
CL  A 500 (-4.7A)
None
None
 1.47A 1uw6A-3gt5A:
undetectable
1uw6B-3gt5A:
undetectable		 1uw6A-3gt5A:
17.82
1uw6B-3gt5A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 8 TYR A  68
THR A 382
TYR A  29
MET A 387
 None
CL  A 500 (-4.7A)
None
None
 1.49A 1uw6D-3gt5A:
undetectable
1uw6E-3gt5A:
undetectable		 1uw6D-3gt5A:
17.82
1uw6E-3gt5A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 8 TYR A  68
THR A 382
TYR A  29
MET A 387
 None
CL  A 500 (-4.7A)
None
None
 1.48A 1uw6G-3gt5A:
undetectable
1uw6H-3gt5A:
undetectable		 1uw6G-3gt5A:
17.82
1uw6H-3gt5A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 7 ALA A 192
TYR A 201
TYR A 129
TYR A 103
 None
 0.99A 2ajvH-3gt5A:
undetectable
2ajvL-3gt5A:
undetectable		 2ajvH-3gt5A:
17.34
2ajvL-3gt5A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 4 ASP A 355
ASP A 374
ASP A 383
GLY A  48
 None
 1.45A 2igtC-3gt5A:
undetectable		 2igtC-3gt5A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.66A 2nmzA-3gt5A:
undetectable		 2nmzA-3gt5A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.65A 2nnkA-3gt5A:
undetectable		 2nnkA-3gt5A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 5 LEU A  88
ALA A 140
LEU A 133
MET A  70
 None
 1.26A 2oaxA-3gt5A:
undetectable		 2oaxA-3gt5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_2
(MINERALOCORTICOID
RECEPTOR)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 4 LEU A 323
TRP A 292
LEU A 299
MET A 353
 None
 1.40A 2oaxE-3gt5A:
0.0		 2oaxE-3gt5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 TYR A 342
ASP A  11
HIS A  21
 None
 0.88A 3e23A-3gt5A:
undetectable		 3e23A-3gt5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		5 / 11 TYR A  90
ASP A  82
ALA A  83
ASP A  35
ILE A  34
 None
 1.15A 3id5B-3gt5A:
undetectable		 3id5B-3gt5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		5 / 11 TYR A  90
ASP A  82
ALA A  83
ASP A  35
ILE A  34
 None
 1.15A 3id5F-3gt5A:
undetectable		 3id5F-3gt5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.73A 3k4vA-3gt5A:
undetectable		 3k4vA-3gt5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.69A 3k4vD-3gt5A:
undetectable		 3k4vD-3gt5A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.71A 3nduD-3gt5A:
undetectable		 3nduD-3gt5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.74A 3pwrA-3gt5A:
undetectable		 3pwrA-3gt5A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 ARG A 204
VAL A 125
THR A 147
 None
 0.71A 3tl9A-3gt5A:
undetectable		 3tl9A-3gt5A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 4 ALA A 188
ALA A 191
ALA A 192
ALA A 195
 None
 0.13A 4oaeA-3gt5A:
undetectable		 4oaeA-3gt5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		5 / 12 PHE A 155
ALA A 167
THR A  62
TYR A 103
VAL A  91
 None
 1.29A 4qynA-3gt5A:
undetectable		 4qynA-3gt5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 MET A 185
GLN A 216
TYR A 228
 None
 0.90A 4udcA-3gt5A:
undetectable		 4udcA-3gt5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		3 / 3 LYS A 164
GLN A 170
ASN A 172
 None
 1.08A 5l2tA-3gt5A:
undetectable		 5l2tA-3gt5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 6 GLU A 187
THR A 382
TYR A 384
TYR A 120
 None
CL  A 500 (-4.7A)
None
None
 1.14A 5lrbA-3gt5A:
undetectable		 5lrbA-3gt5A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		4 / 8 GLN A 179
GLY A 251
TRP A 317
ASP A 311
 None
 1.00A 5vlmH-3gt5A:
1.0		 5vlmH-3gt5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		5 / 11 ALA A 330
TRP A 339
LEU A  18
ASP A  11
ALA A 326
 None
 1.13A 6dk1A-3gt5A:
undetectable		 6dk1A-3gt5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		5 / 11 ALA A 330
LEU A  18
ASP A  11
ALA A 327
LEU A 328
 None
 1.41A 6dk1B-3gt5A:
undetectable		 6dk1B-3gt5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE
(Xylella
fastidiosa) 		5 / 11 ALA A 330
TRP A 339
LEU A  18
ASP A  11
ALA A 326
 None
 1.12A 6dk1C-3gt5A:
undetectable		 6dk1C-3gt5A:
19.36