SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gtd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 4 HIS A 271
LEU A  44
LEU A 370
LEU A 281
 None
 0.96A 1a4lD-3gtdA:
undetectable		 1a4lD-3gtdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		3 / 3 SER A 300
GLY A 299
ARG A 186
 None
 0.69A 1t9wA-3gtdA:
undetectable		 1t9wA-3gtdA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 12 ASP A 403
ILE A 395
ILE A 181
ARG A 402
ASP A 451
 None
 1.24A 2qmjA-3gtdA:
undetectable		 2qmjA-3gtdA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 9 ILE A 150
PHE A 246
ALA A 247
VAL A 250
 None
 0.70A 2vufA-3gtdA:
2.0		 2vufA-3gtdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		3 / 3 SER A 372
THR A 152
PHE A 144
 None
 0.78A 2x91A-3gtdA:
2.4		 2x91A-3gtdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 7 VAL A 134
ILE A 110
ALA A 114
VAL A 128
 None
 0.62A 2xrzB-3gtdA:
undetectable		 2xrzB-3gtdA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 8 LEU A 225
THR A 152
VAL A 153
ALA A  47
 None
 0.89A 3ax9A-3gtdA:
undetectable		 3ax9A-3gtdA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 12 GLN A 138
VAL A 134
VAL A 250
ILE A  50
THR A 146
 None
 1.29A 3em0A-3gtdA:
undetectable		 3em0A-3gtdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 9 ILE A 150
ALA A 261
LEU A 225
LEU A  51
ALA A  47
 None
 1.05A 3ozvB-3gtdA:
undetectable		 3ozvB-3gtdA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		6 / 12 VAL A 380
LEU A 164
VAL A 340
ALA A 285
SER A 287
LEU A 288
 None
 1.49A 3pghC-3gtdA:
undetectable		 3pghC-3gtdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 12 ASP A 403
ILE A 395
ILE A 181
ARG A 402
ASP A 451
 None
 1.16A 3phaA-3gtdA:
undetectable		 3phaA-3gtdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 12 ASP A 403
ILE A 395
ILE A 181
ARG A 402
ASP A 451
 None
 1.15A 3phaB-3gtdA:
undetectable		 3phaB-3gtdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 8 LEU A 225
THR A 152
VAL A 153
ALA A  47
 None
 0.84A 3uniB-3gtdA:
undetectable		 3uniB-3gtdA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 12 THR A 100
ASN A 105
LYS A  52
VAL A 134
ASP A 132
 MLI  A 462 (-2.8A)
None
None
None
None
 1.35A 4njkA-3gtdA:
undetectable		 4njkA-3gtdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		5 / 9 SER A 143
GLN A  57
ASN A 107
ILE A 110
ALA A 114
 None
 1.33A 5entC-3gtdA:
undetectable		 5entC-3gtdA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 5 VAL A 409
PRO A 414
GLY A 417
TYR A 418
 None
 1.29A 5x80A-3gtdA:
undetectable
5x80B-3gtdA:
undetectable		 5x80A-3gtdA:
19.20
5x80B-3gtdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 5 PRO A 414
GLY A 417
TYR A 418
VAL A 409
 None
 1.28A 5x80C-3gtdA:
0.7
5x80D-3gtdA:
undetectable		 5x80C-3gtdA:
19.20
5x80D-3gtdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 4 PHE A 277
LEU A 375
LEU A 160
VAL A 340
 None
 1.16A 5xxiA-3gtdA:
undetectable		 5xxiA-3gtdA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		4 / 5 ILE A 215
GLN A 159
THR A 156
LEU A 288
 None
 1.09A 6f3mD-3gtdA:
undetectable		 6f3mD-3gtdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3gtd FUMARATE HYDRATASE
CLASS II
(Rickettsia
prowazekii) 		3 / 3 THR A 280
ALA A 218
LYS A 220
 None
 0.74A 6fgcA-3gtdA:
undetectable		 6fgcA-3gtdA:
22.24