SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gtu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 7 TYR B  10
GLY B  15
ILE B 115
TYR B 119
 None
 0.31A 11gsB-3gtuB:
27.0		 11gsB-3gtuB:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 6 ILE B  79
GLU B 104
LEU B 162
LEU B  23
 None
 0.96A 1mt1B-3gtuB:
undetectable
1mt1C-3gtuB:
undetectable		 1mt1B-3gtuB:
20.36
1mt1C-3gtuB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 5 LEU B  22
TYR B 200
GLN B 205
TYR B  31
 None
 1.33A 1yc2B-3gtuB:
undetectable
1yc2C-3gtuB:
undetectable		 1yc2B-3gtuB:
22.61
1yc2C-3gtuB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 ILE B 197
TYR B 164
THR B 163
LEU B 167
LEU B 178
 None
 1.35A 2mjiA-3gtuB:
undetectable		 2mjiA-3gtuB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		3 / 3 ASN B  77
ASP B 165
GLN B 169
 None
 0.83A 3eeyC-3gtuB:
undetectable		 3eeyC-3gtuB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		3 / 3 ASN B  77
ASP B 165
GLN B 169
 None
 0.82A 3eeyD-3gtuB:
undetectable		 3eeyD-3gtuB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		3 / 3 ASN B  77
ASP B 165
GLN B 169
 None
 0.83A 3eeyE-3gtuB:
undetectable		 3eeyE-3gtuB:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 8 TYR B  10
GLY B  15
ILE B 115
TYR B 119
 None
 0.38A 3n9jB-3gtuB:
27.0		 3n9jB-3gtuB:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 5 GLY B  15
LEU B  80
LEU B   8
LEU B 201
 None
 0.82A 4o8fA-3gtuB:
undetectable		 4o8fA-3gtuB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 TYR B 119
ILE B 211
GLN B 169
ALA B  17
ILE B 115
 None
 1.48A 4rp9A-3gtuB:
undetectable		 4rp9A-3gtuB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 6 ASP B 165
HIS B  18
ILE B  20
TYR B  10
 None
 1.30A 5ih0A-3gtuB:
undetectable		 5ih0A-3gtuB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_B_ACRB1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 9 GLU B  33
THR B  29
TYR B  31
GLY B   9
TYR B  10
 None
 1.46A 5lrbB-3gtuB:
0.0		 5lrbB-3gtuB:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 5 LEU B 114
CYH B 177
LEU B 178
ASP B 168
 None
 1.43A 5mafA-3gtuB:
undetectable		 5mafA-3gtuB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 7 LEU B  23
PHE B 161
ILE B 166
ASN B  77
 None
 0.91A 5n5dA-3gtuB:
undetectable		 5n5dA-3gtuB:
17.70