SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_C_SAMC301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	3gtz	PUTATIVE TRANSLATION INITIATION INHIBITOR (Salmonella enterica)	5 / 12	LEU A 31 TYR A 104 ASN A 101 ALA A 35 ALA A 75	None	1.05A	2bm9C-3gtzA: undetectable	2bm9C-3gtzA: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_B_SAMB301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	3gtz	PUTATIVE TRANSLATION INITIATION INHIBITOR (Salmonella enterica)	5 / 12	LEU A 31 TYR A 104 ASN A 101 ALA A 35 ALA A 75	None	1.07A	2br4B-3gtzA: undetectable	2br4B-3gtzA: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_A_DVAA6_0 (GRAMICIDIN D)	3gtz	PUTATIVE TRANSLATION INITIATION INHIBITOR (Salmonella enterica)	3 / 3	ALA A 82 VAL A 84 TRP A 80	None	0.93A	2izqA-3gtzA: undetectable 2izqB-3gtzA: undetectable	2izqA-3gtzA: 28.57 2izqB-3gtzA: 28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X2T_I_PEMI202_1 (HEMOGLOBIN SUBUNIT ALPHA HEMOGLOBIN SUBUNIT BETA)	3gtz	PUTATIVE TRANSLATION INITIATION INHIBITOR (Salmonella enterica)	4 / 8	ALA A 35 THR A 39 THR A 42 ALA A 63	None	0.71A	5x2tI-3gtzA: undetectable 5x2tJ-3gtzA: undetectable 5x2tK-3gtzA: undetectable 5x2tL-3gtzA: undetectable	5x2tI-3gtzA: 16.78 5x2tJ-3gtzA: 24.84 5x2tK-3gtzA: 16.78 5x2tL-3gtzA: 24.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2BM9_C_SAMC301_0","CEPHALOSPORIN HYDROXYLASE CMCI","3gtz","PUTATIVE TRANSLATION INITIATION INHIBITOR","Salmonella enterica",5,"LEU A  31;TYR A 104;ASN A 101;ALA A  35;ALA A  75","None","1.05A","2bm9C-3gtzA:undetectable","2bm9C-3gtzA:18.22"],["2BR4_B_SAMB301_0","CEPHALOSPORIN HYDROXYLASE CMCI","3gtz","PUTATIVE TRANSLATION INITIATION INHIBITOR","Salmonella enterica",5,"LEU A  31;TYR A 104;ASN A 101;ALA A  35;ALA A  75","None","1.07A","2br4B-3gtzA:undetectable","2br4B-3gtzA:18.22"],["2IZQ_A_DVAA6_0","GRAMICIDIN D","3gtz","PUTATIVE TRANSLATION INITIATION INHIBITOR","Salmonella enterica",3,"ALA A  82;VAL A  84;TRP A  80","None","0.93A","2izqA-3gtzA:undetectable;2izqB-3gtzA:undetectable","2izqA-3gtzA:28.57;2izqB-3gtzA:28.57"],["5X2T_I_PEMI202_1","HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA;HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA","3gtz","PUTATIVE TRANSLATION INITIATION INHIBITOR","Salmonella enterica",4,"ALA A  35;THR A  39;THR A  42;ALA A  63","None","0.71A","5x2tI-3gtzA:undetectable;5x2tJ-3gtzA:undetectable;5x2tK-3gtzA:undetectable;5x2tL-3gtzA:undetectable","5x2tI-3gtzA:16.78;5x2tJ-3gtzA:24.84;5x2tK-3gtzA:16.78;5x2tL-3gtzA:24.84"]]