SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3gu0 TRIGGER FACTOR
(Thermotoga
maritima) 		5 / 10 VAL A 339
VAL A 283
ILE A 282
GLU A 404
LEU A 275
 None
 1.15A 1ihiA-3gu0A:
undetectable		 1ihiA-3gu0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3gu0 TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 6 ALA A 391
LEU A 384
GLU A 359
LEU A 363
 None
 0.74A 1mt1D-3gu0A:
undetectable
1mt1E-3gu0A:
undetectable		 1mt1D-3gu0A:
15.66
1mt1E-3gu0A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3gu0 TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 7 ASP A 140
SER A 240
LEU A 255
GLU A 258
 None
 1.07A 2cdqB-3gu0A:
undetectable		 2cdqB-3gu0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3gu0 TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 5 LEU A 384
VAL A 397
LEU A 398
ARG A 338
 None
 1.06A 2oiqA-3gu0A:
2.1		 2oiqA-3gu0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3gu0 TRIGGER FACTOR
(Thermotoga
maritima) 		3 / 3 VAL A 193
TYR A 182
GLU A 188
 None
 0.81A 5zmqD-3gu0A:
undetectable
5zmqE-3gu0A:
undetectable		 5zmqD-3gu0A:
19.16
5zmqE-3gu0A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gu0 TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 8 ASP A 289
ARG A  12
GLU A 104
GLU A   7
 None
 1.19A 6mn4D-3gu0A:
undetectable		 6mn4D-3gu0A:
20.10