SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		3 / 3 GLU A  16
ALA A  11
SER A   8
 None
 0.58A 1errB-3gueA:
undetectable		 1errB-3gueA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 7 ARG A 395
THR A 391
VAL A 390
ALA A 372
 None
 0.97A 1fo4B-3gueA:
undetectable		 1fo4B-3gueA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 LEU A 143
GLY A  84
GLY A  83
THR A 139
LEU A 107
 None
UPG  A 484 (-3.3A)
UPG  A 484 (-3.0A)
None
None
 1.07A 1liiA-3gueA:
undetectable		 1liiA-3gueA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 LEU A 323
VAL A 193
VAL A 349
GLY A 191
LEU A 312
 None
None
DTU  A 489 (-4.2A)
None
None
 1.42A 1lwfA-3gueA:
undetectable		 1lwfA-3gueA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.27A 1mj2A-3gueA:
undetectable		 1mj2A-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mj2C-3gueA:
undetectable		 1mj2C-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.33A 1mjoA-3gueA:
undetectable		 1mjoA-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mjoB-3gueA:
undetectable		 1mjoB-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mjoC-3gueA:
undetectable		 1mjoC-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 11 VAL A 482
VAL A 480
ASN A 461
GLU A 465
ILE A 469
 None
 1.41A 1t6zB-3gueA:
undetectable		 1t6zB-3gueA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 6 LYS A 237
LEU A 239
PRO A  58
VAL A 364
 None
 1.16A 2dqyC-3gueA:
undetectable		 2dqyC-3gueA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 LEU A 149
LEU A 129
THR A 139
TYR A 146
LEU A 114
 None
 1.35A 3fsuA-3gueA:
undetectable		 3fsuA-3gueA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 GLU A 288
GLY A  44
GLU A 279
ALA A 350
GLY A 256
 None
None
UPG  A 484 (-2.7A)
UPG  A 484 ( 4.2A)
UPG  A 484 (-3.5A)
 1.33A 3jzjA-3gueA:
1.5		 3jzjA-3gueA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 10 LEU A 323
VAL A 193
VAL A 349
GLY A 191
LEU A 312
 None
None
DTU  A 489 (-4.2A)
None
None
 1.50A 3qipA-3gueA:
undetectable		 3qipA-3gueA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 4 LEU A  85
GLY A  86
GLY A  93
THR A 135
 None
None
SO4  A 487 (-3.4A)
None
 0.90A 3si7A-3gueA:
undetectable		 3si7A-3gueA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 6 GLY A 421
GLU A 423
ASP A 412
ASP A 420
 None
 1.01A 4uckB-3gueA:
undetectable		 4uckB-3gueA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 11 LEU A 323
VAL A 193
VAL A 349
GLY A 191
LEU A 312
 None
None
DTU  A 489 (-4.2A)
None
None
 1.44A 5hbmA-3gueA:
undetectable		 5hbmA-3gueA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 LEU A 396
LEU A  97
LEU A 222
ALA A 111
LEU A 129
 None
 1.13A 5ienB-3gueA:
undetectable		 5ienB-3gueA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 LEU A 312
ILE A 307
LEU A 230
PHE A 358
ILE A 305
 None
 1.07A 5j7wC-3gueA:
undetectable		 5j7wC-3gueA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		3 / 3 GLY A 413
ASP A 412
ASN A 461
 None
 0.55A 5jglA-3gueA:
undetectable		 5jglA-3gueA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		3 / 3 THR A 333
SER A 341
ASP A 180
 None
 0.82A 5kvaA-3gueA:
undetectable		 5kvaA-3gueA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 10 LEU A 323
VAL A 193
VAL A 349
GLY A 191
LEU A 312
 None
None
DTU  A 489 (-4.2A)
None
None
 1.40A 6bsiA-3gueA:
undetectable		 6bsiA-3gueA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 10 LEU A 323
VAL A 193
VAL A 349
GLY A 191
LEU A 312
 None
None
DTU  A 489 (-4.2A)
None
None
 1.48A 6bsjA-3gueA:
1.3		 6bsjA-3gueA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 10 LEU A 475
LEU A 433
ASP A 386
ILE A 469
GLY A 448
 None
 1.21A 6dm0B-3gueA:
undetectable
6dm0C-3gueA:
undetectable		 6dm0B-3gueA:
11.02
6dm0C-3gueA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 6 GLN A 282
GLU A 348
HIS A 190
ALA A 350
 None
GOL  A 490 (-3.6A)
UPG  A 484 (-3.7A)
UPG  A 484 ( 4.2A)
 1.34A 6f6jC-3gueA:
undetectable
6f6jD-3gueA:
undetectable		 6f6jC-3gueA:
22.22
6f6jD-3gueA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 10 VAL A 364
LEU A 242
LEU A 239
LEU A 231
LEU A 230
 None
 0.93A 6f6nA-3gueA:
undetectable
6f6nB-3gueA:
undetectable		 6f6nA-3gueA:
12.39
6f6nB-3gueA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 6 ASP A 393
GLU A 369
CYH A 246
GLU A 244
 None
 1.38A 6mn5A-3gueA:
undetectable		 6mn5A-3gueA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 6 ASP A 393
GLU A 369
CYH A 246
GLU A 244
 None
 1.37A 6mn5C-3gueA:
undetectable		 6mn5C-3gueA:
12.53