SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens) 		5 / 11 ILE A  23
ILE A  63
VAL A  21
PHE A 161
VAL A 163
 None
 1.15A 3rf4B-3gutA:
undetectable
3rf4C-3gutA:
undetectable		 3rf4B-3gutA:
16.73
3rf4C-3gutA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens) 		5 / 12 GLN A 119
GLN A 132
GLU A  89
GLY A  92
GLY A  98
 None
 0.95A 3tegA-3gutA:
undetectable		 3tegA-3gutA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens) 		5 / 12 LEU A  90
LEU A 159
PHE A 113
LEU A 116
ARG A  96
 None
 1.05A 5hnwB-3gutA:
undetectable		 5hnwB-3gutA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens) 		5 / 12 LEU A  90
LEU A 159
PHE A 113
LEU A 116
ARG A  96
 None
 1.02A 5hnyB-3gutA:
undetectable		 5hnyB-3gutA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens) 		4 / 6 GLU A 225
ARG A 236
ARG A 274
ARG A 273
 None
 1.25A 5l6eA-3gutA:
undetectable
5l6eB-3gutA:
undetectable		 5l6eA-3gutA:
21.55
5l6eB-3gutA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens) 		3 / 3 LYS A  28
LYS A  56
SER A  51
 None
 1.49A 5odiA-3gutA:
undetectable		 5odiA-3gutA:
15.24