SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3guv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  88
VAL A  82
PHE A  63
MET A  67
 None
 0.95A 1wrlB-3guvA:
undetectable		 1wrlB-3guvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PHE A  63
SER A  97
LEU A  99
 None
 0.81A 2w1bA-3guvA:
undetectable		 2w1bA-3guvA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 MET A  32
VAL A  80
GLU A  46
 None
 0.88A 3c6gA-3guvA:
undetectable		 3c6gA-3guvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A  84
SER A  24
GLN A  28
 None
 1.16A 3si7A-3guvA:
undetectable		 3si7A-3guvA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  75
VAL A  44
GLY A  45
ASP A  69
 None
 1.46A 3w9tA-3guvA:
undetectable		 3w9tA-3guvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  75
VAL A  44
GLY A  45
ASP A  69
 None
 1.44A 3w9tB-3guvA:
undetectable		 3w9tB-3guvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  75
VAL A  44
GLY A  45
ASP A  69
 None
 1.45A 3w9tC-3guvA:
undetectable		 3w9tC-3guvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  75
VAL A  44
GLY A  45
ASP A  69
 None
 1.46A 3w9tD-3guvA:
undetectable		 3w9tD-3guvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  75
VAL A  44
GLY A  45
ASP A  69
 None
 1.45A 3w9tE-3guvA:
undetectable		 3w9tE-3guvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  75
VAL A  44
GLY A  45
ASP A  69
 None
 1.45A 3w9tG-3guvA:
undetectable		 3w9tG-3guvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ILE A 110
GLY A  45
ALA A  36
GLN A  62
 None
 0.94A 4g0uB-3guvA:
3.5		 4g0uB-3guvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A 116
LEU A  85
VAL A  95
VAL A  80
LEU A 109
 None
 1.10A 4g1bC-3guvA:
undetectable		 4g1bC-3guvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLU A  48
TYR A  47
GLU A  46
ARG A  65
 None
 1.19A 4r87J-3guvA:
undetectable
4r87L-3guvA:
undetectable		 4r87J-3guvA:
19.25
4r87L-3guvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A  48
TYR A  47
ARG A  65
 None
 0.83A 5uunB-3guvA:
undetectable		 5uunB-3guvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 GLY A  45
MET A  66
ASP A  69
ILE A  70
VAL A  77
 None
 1.45A 5v0iA-3guvA:
undetectable		 5v0iA-3guvA:
19.82