SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3guw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		4 / 5 HIS A   6
HIS A  73
HIS A 129
ASP A 207
 ZN  A 301 (-3.0A)
None
ZN  A 302 (-3.2A)
ZN  A 301 (-2.9A)
 0.75A 1e9yB-3guwA:
14.6		 1e9yB-3guwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 6 HIS A   6
HIS A   8
HIS A  73
HIS A 129
ASP A 207
 ZN  A 301 (-3.0A)
ZN  A 301 (-3.5A)
None
ZN  A 302 (-3.2A)
ZN  A 301 (-2.9A)
 0.76A 1fweC-3guwA:
14.8		 1fweC-3guwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 6 HIS A   6
HIS A   8
HIS A  73
HIS A 129
HIS A 160
 ZN  A 301 (-3.0A)
ZN  A 301 (-3.5A)
None
ZN  A 302 (-3.2A)
ZN  A 302 (-3.7A)
 1.13A 1fweC-3guwA:
14.8		 1fweC-3guwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 12 GLU A  98
HIS A 129
HIS A   6
ASN A 205
ASP A 207
 ZN  A 301 ( 2.9A)
ZN  A 302 (-3.2A)
ZN  A 301 (-3.0A)
None
ZN  A 301 (-2.9A)
 1.07A 1ituA-3guwA:
5.7		 1ituA-3guwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 12 THR A 130
ASP A 159
GLY A 177
LEU A 170
LEU A 166
 None
 1.10A 1rjdA-3guwA:
undetectable		 1rjdA-3guwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 12 THR A 130
ASP A 159
GLY A 177
LEU A 170
LEU A 166
 None
 1.10A 1rjdB-3guwA:
undetectable		 1rjdB-3guwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 12 THR A 130
ASP A 159
GLY A 177
LEU A 170
LEU A 166
 None
 1.09A 1rjdC-3guwA:
undetectable		 1rjdC-3guwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		4 / 6 ALA A  69
PRO A  56
LEU A  51
THR A  52
 None
 1.01A 4dtzA-3guwA:
undetectable		 4dtzA-3guwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		4 / 5 HIS A   6
HIS A  73
HIS A 129
ASP A 207
 ZN  A 301 (-3.0A)
None
ZN  A 302 (-3.2A)
ZN  A 301 (-2.9A)
 0.73A 4h9mA-3guwA:
6.3		 4h9mA-3guwA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		5 / 11 PHE A  48
GLY A  97
GLY A  71
HIS A 129
HIS A   6
 None
None
None
ZN  A 302 (-3.2A)
ZN  A 301 (-3.0A)
 1.18A 4l8fD-3guwA:
undetectable		 4l8fD-3guwA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		6 / 6 HIS A   6
HIS A   8
HIS A  73
HIS A 129
HIS A 160
ASP A 207
 ZN  A 301 (-3.0A)
ZN  A 301 (-3.5A)
None
ZN  A 302 (-3.2A)
ZN  A 302 (-3.7A)
ZN  A 301 (-2.9A)
 1.00A 4ubpC-3guwA:
14.2		 4ubpC-3guwA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		4 / 6 PHE A  54
SER A   9
PRO A  56
LEU A  51
 None
 1.48A 5dzka-3guwA:
3.6
5dzko-3guwA:
undetectable		 5dzka-3guwA:
22.22
5dzko-3guwA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		4 / 6 HIS A 129
HIS A   8
HIS A   6
HIS A  73
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.5A)
ZN  A 301 (-3.0A)
None
 1.08A 5nelB-3guwA:
4.4
5nelC-3guwA:
2.5		 5nelB-3guwA:
22.78
5nelC-3guwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 3guw UNCHARACTERIZED
PROTEIN AF_1765
(Archaeoglobus
fulgidus) 		4 / 6 ASP A 167
ASN A 162
LEU A 178
PHE A 202
 None
 1.20A 6ekuA-3guwA:
undetectable		 6ekuA-3guwA:
15.34