SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3guz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLU A 104
THR A 103
LEU A  68
 None
 0.70A 1v8bC-3guzA:
2.1		 1v8bC-3guzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		5 / 8 GLN A  61
HIS A 126
VAL A 130
ASP A 152
GLN A 155
 PAF  A 177 (-3.1A)
None
PAF  A 177 ( 4.5A)
None
PAF  A 177 (-2.9A)
 0.95A 3uy4A-3guzA:
26.4		 3uy4A-3guzA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLN A  61
ASP A 152
GLN A 154
 PAF  A 177 (-3.1A)
None
None
 0.87A 4aztA-3guzA:
undetectable		 4aztA-3guzA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		4 / 8 ARG A  73
ASP A  78
LEU A  75
ILE A   3
 None
 1.01A 4k0bA-3guzA:
undetectable		 4k0bA-3guzA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A  36
LEU A  40
GLN A  61
GLY A 149
LYS A 151
 PAF  A 178 (-4.5A)
PAF  A 178 ( 4.7A)
PAF  A 177 (-3.1A)
PAF  A 178 (-3.4A)
PAF  A 178 (-4.6A)
 1.02A 5hg0A-3guzA:
22.8		 5hg0A-3guzA:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A  36
LEU A  40
GLN A  61
TYR A  71
GLY A 149
 PAF  A 178 (-4.5A)
PAF  A 178 ( 4.7A)
PAF  A 177 (-3.1A)
None
PAF  A 178 (-3.4A)
 0.71A 5hg0A-3guzA:
22.8		 5hg0A-3guzA:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  40
GLN A  61
TYR A  71
GLY A 149
ASP A 152
 PAF  A 178 ( 4.7A)
PAF  A 177 (-3.1A)
None
PAF  A 178 (-3.4A)
None
 1.01A 5hg0A-3guzA:
22.8		 5hg0A-3guzA:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A  36
HIS A  37
LEU A  40
TYR A  71
GLY A 149
 PAF  A 178 (-4.5A)
PAF  A 178 ( 3.8A)
PAF  A 178 ( 4.7A)
None
PAF  A 178 (-3.4A)
 0.76A 5hg0B-3guzA:
22.7		 5hg0B-3guzA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3guz PANTOTHENATE
SYNTHETASE
(Escherichia
coli) 		4 / 6 LEU A  40
CYH A 147
GLY A 174
ARG A  47
 PAF  A 178 ( 4.7A)
None
None
None
 1.29A 6gtqB-3guzA:
undetectable
6gtqD-3guzA:
undetectable		 6gtqB-3guzA:
21.32
6gtqD-3guzA:
14.71