SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		5 / 9 LEU B 344
LEU B 390
ILE B 386
LEU B 325
ILE B 321
 None
 1.23A 2f78A-3gv5B:
undetectable		 2f78A-3gv5B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		5 / 9 LEU B 344
LEU B 390
ILE B 386
LEU B 325
ILE B 321
 None
 1.22A 2f78B-3gv5B:
undetectable		 2f78B-3gv5B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		5 / 9 LEU B 344
LEU B 390
ILE B 386
LEU B 325
ILE B 321
 None
 1.21A 2f7aB-3gv5B:
undetectable		 2f7aB-3gv5B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		4 / 6 LEU B 205
ASN B 202
LYS B  28
ASP B 131
 None
 1.39A 2w98A-3gv5B:
undetectable
2w98B-3gv5B:
undetectable		 2w98A-3gv5B:
22.05
2w98B-3gv5B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		4 / 8 ILE B 242
GLY B 243
VAL B 258
SER B 232
 None
 0.90A 4acbB-3gv5B:
undetectable
4acbC-3gv5B:
undetectable		 4acbB-3gv5B:
22.31
4acbC-3gv5B:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		3 / 3 LEU B 113
GLU B 115
SER B 117
 None
 0.83A 4ccqA-3gv5B:
undetectable		 4ccqA-3gv5B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		4 / 6 SER B 154
SER B 177
ARG B 139
GLU B 182
 None
 1.13A 4eysA-3gv5B:
undetectable		 4eysA-3gv5B:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		6 / 12 GLY B  56
LEU B  50
THR B  65
VAL B  75
VAL B  92
LEU B  91
 None
None
ADI  B 425 (-3.0A)
None
None
None
 1.39A 5kpcA-3gv5B:
undetectable		 5kpcA-3gv5B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		6 / 12 GLY B  56
LEU B  50
THR B  65
VAL B  92
LEU B  91
ALA B  84
 None
None
ADI  B 425 (-3.0A)
None
None
None
 1.45A 5kpcA-3gv5B:
undetectable		 5kpcA-3gv5B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3gv5 DNA POLYMERASE IOTA
(Homo
sapiens) 		5 / 12 GLY B 195
LYS B 108
GLU B 111
LEU B 113
GLU B 114
 None
 1.22A 5nwuA-3gv5B:
undetectable		 5nwuA-3gv5B:
7.41