SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 LEU A 182
GLY A 217
GLY A 215
ILE A 202
LEU A 111
 None
 0.98A 1p91B-3gvdA:
undetectable		 1p91B-3gvdA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ALA A 236
THR A 235
ALA A 218
ALA A 222
GLY A 203
 None
 0.87A 3mg0Y-3gvdA:
undetectable
3mg0Z-3gvdA:
undetectable		 3mg0Y-3gvdA:
22.10
3mg0Z-3gvdA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 10 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 CYS  A 501 ( 4.5A)
None
None
None
None
 1.10A 4dt8B-3gvdA:
undetectable		 4dt8B-3gvdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
 CYS  A 276 (-3.5A)
None
CYS  A 276 (-2.7A)
None
 0.93A 4e7gA-3gvdA:
undetectable		 4e7gA-3gvdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 LEU A 156
ILE A 202
ILE A 208
GLY A 183
ILE A 176
 None
None
None
CYS  A 501 ( 3.9A)
None
 0.94A 4q1yB-3gvdA:
undetectable		 4q1yB-3gvdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 6 GLY A 199
GLU A 198
ASP A 250
ASP A 173
 None
 0.74A 4uckB-3gvdA:
undetectable		 4uckB-3gvdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 SER A 224
THR A 235
SER A 263
GLY A 262
ALA A 237
 None
 1.33A 5l5zV-3gvdA:
undetectable
5l5zb-3gvdA:
undetectable		 5l5zV-3gvdA:
23.41
5l5zb-3gvdA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 6 PRO A 194
VAL A 170
VAL A 174
ILE A 208
 None
 0.83A 5pbeA-3gvdA:
undetectable		 5pbeA-3gvdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 6 VAL A 170
LEU A 111
ARG A 115
HIS A 118
 None
 1.04A 6e43D-3gvdA:
undetectable		 6e43D-3gvdA:
21.27