SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 10 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.23A 1aqbA-3gvhA:
undetectable		 1aqbA-3gvhA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 9 GLY A  10
ASP A  34
ILE A  35
TYR A  66
ALA A  79
 NAD  A 400 ( 4.1A)
NAD  A 400 (-2.9A)
NAD  A 400 (-4.4A)
None
NAD  A 400 (-3.4A)
 0.56A 1cetA-3gvhA:
44.7		 1cetA-3gvhA:
46.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 11 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.26A 1hbpA-3gvhA:
undetectable		 1hbpA-3gvhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 11 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.42A 1kt6A-3gvhA:
undetectable		 1kt6A-3gvhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 11 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.32A 1kt7A-3gvhA:
undetectable		 1kt7A-3gvhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 TYR A  66
THR A 120
GLY A  80
ILE A  69
LEU A 130
 None
NAD  A 400 ( 4.3A)
NAD  A 400 (-4.5A)
None
None
 1.19A 1r30A-3gvhA:
undetectable		 1r30A-3gvhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 TYR A  66
THR A 120
GLY A  80
ILE A  69
LEU A 130
 None
NAD  A 400 ( 4.3A)
NAD  A 400 (-4.5A)
None
None
 1.19A 1r30B-3gvhA:
undetectable		 1r30B-3gvhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 TYR A 246
VAL A 127
ILE A 117
VAL A 256
LEU A 123
 None
None
None
None
NAD  A 400 ( 4.2A)
 1.43A 1z9hA-3gvhA:
2.2		 1z9hA-3gvhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 TYR A 246
VAL A 127
ILE A 117
VAL A 256
LEU A 123
 None
None
None
None
NAD  A 400 ( 4.2A)
 1.41A 1z9hB-3gvhA:
undetectable		 1z9hB-3gvhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 TYR A 246
VAL A 127
ILE A 117
VAL A 256
LEU A 123
 None
None
None
None
NAD  A 400 ( 4.2A)
 1.43A 1z9hC-3gvhA:
2.2		 1z9hC-3gvhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		4 / 8 THR A 275
VAL A 147
GLY A 146
ILE A 117
 None
 0.51A 2a1mB-3gvhA:
undetectable		 2a1mB-3gvhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  15
GLY A  10
ILE A 119
ALA A 236
THR A  39
 None
NAD  A 400 ( 4.1A)
NAD  A 400 (-4.7A)
None
None
 1.04A 2vdvE-3gvhA:
5.2		 2vdvE-3gvhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 11 GLY A  15
GLY A  10
ILE A 119
ALA A 236
THR A  39
 None
NAD  A 400 ( 4.1A)
NAD  A 400 (-4.7A)
None
None
 1.04A 2vdvF-3gvhA:
4.9		 2vdvF-3gvhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 11 ILE A 240
ASN A 121
ILE A 117
VAL A  30
LEU A   8
 None
NAD  A 400 (-3.6A)
None
None
None
 1.27A 3a51A-3gvhA:
undetectable		 3a51A-3gvhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A 240
ASN A 121
ILE A 117
VAL A  30
LEU A   8
 None
NAD  A 400 (-3.6A)
None
None
None
 1.23A 3a51E-3gvhA:
undetectable		 3a51E-3gvhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  15
GLY A  10
ILE A 119
ALA A 236
THR A  39
 None
NAD  A 400 ( 4.1A)
NAD  A 400 (-4.7A)
None
None
 1.09A 3ckkA-3gvhA:
5.3		 3ckkA-3gvhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		4 / 6 GLN A 241
GLU A 244
LYS A  25
LEU A  27
 None
 0.86A 3h5gA-3gvhA:
undetectable
3h5gC-3gvhA:
undetectable		 3h5gA-3gvhA:
11.54
3h5gC-3gvhA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		4 / 7 MET A 126
LEU A  97
ARG A  89
GLY A 307
 None
 1.10A 3hcnA-3gvhA:
4.4		 3hcnA-3gvhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 9 ALA A  68
ASP A  65
GLY A 106
ILE A 107
LEU A   8
 None
 0.98A 3u7sA-3gvhA:
undetectable		 3u7sA-3gvhA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 9 GLY A  71
GLY A 106
ILE A 107
LEU A   8
VAL A  31
 None
 1.03A 3u7sB-3gvhA:
undetectable		 3u7sB-3gvhA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A 177
GLY A 218
ASP A 178
GLY A 272
PRO A 182
 None
 1.12A 4blvA-3gvhA:
4.3		 4blvA-3gvhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		4 / 8 SER A 179
GLY A 174
ALA A 151
GLY A 146
 None
 0.89A 5albL-3gvhA:
undetectable		 5albL-3gvhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 9 ALA A 316
ASP A  90
LEU A  93
GLY A  94
LEU A 319
 None
 1.16A 5dqfA-3gvhA:
undetectable		 5dqfA-3gvhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		5 / 10 ILE A 288
LEU A 290
VAL A 266
ILE A 285
LEU A 260
 None
 1.08A 5ienB-3gvhA:
undetectable		 5ienB-3gvhA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		4 / 6 LEU A 136
VAL A 116
LEU A 130
VAL A  75
 None
 0.97A 5x7zA-3gvhA:
undetectable		 5x7zA-3gvhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3gvh MALATE DEHYDROGENASE
(Brucella
abortus) 		3 / 3 SER A 301
SER A 179
ALA A 257
 None
 0.66A 6dwnC-3gvhA:
undetectable		 6dwnC-3gvhA:
16.06