SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 8 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.82A 1dz9A-3gvpA:
undetectable		 1dz9A-3gvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 8 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.81A 1o76B-3gvpA:
undetectable		 1o76B-3gvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 LEU A 547
LEU A 550
ILE A 307
THR A 315
LEU A 242
 None
 1.26A 1tw4B-3gvpA:
undetectable		 1tw4B-3gvpA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 8 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.90A 1uyuA-3gvpA:
undetectable		 1uyuA-3gvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 8 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.96A 1uyuB-3gvpA:
undetectable		 1uyuB-3gvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 6 ARG A 295
GLU A 284
ASN A 265
ALA A 268
 None
 1.38A 2ejfB-3gvpA:
undetectable		 2ejfB-3gvpA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 ILE A 293
LEU A 314
GLY A 311
ALA A 257
ALA A 256
 None
 1.00A 2oc8A-3gvpA:
undetectable		 2oc8A-3gvpA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 7 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.96A 2zaxA-3gvpA:
undetectable		 2zaxA-3gvpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 10 GLY A 311
ASP A 309
ILE A 307
VAL A 333
LEU A 343
 None
 1.22A 3ay0B-3gvpA:
6.4		 3ay0B-3gvpA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 ILE A 485
VAL A 475
ILE A 378
LEU A 523
ARG A 522
 None
None
None
NAD  A 608 ( 4.4A)
None
 1.25A 3fpjB-3gvpA:
8.4		 3fpjB-3gvpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 7 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.93A 3fwgB-3gvpA:
undetectable		 3fwgB-3gvpA:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 239
ASP A 310
GLU A 335
LYS A 365
 None
 1.39A 3g1uC-3gvpA:
44.9		 3g1uC-3gvpA:
52.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 11 GLY A 399
GLY A 401
GLU A 422
ILE A 423
ASP A 424
 NAD  A 608 (-3.6A)
NAD  A 608 (-3.4A)
NAD  A 608 (-2.9A)
NAD  A 608 (-4.3A)
None
 0.55A 3grvA-3gvpA:
4.0		 3grvA-3gvpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 GLY A 399
GLY A 401
GLU A 422
ILE A 423
ASP A 424
 NAD  A 608 (-3.6A)
NAD  A 608 (-3.4A)
NAD  A 608 (-2.9A)
NAD  A 608 (-4.3A)
None
 0.53A 3gryA-3gvpA:
4.4		 3gryA-3gvpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 9 THR A 245
GLY A 247
GLU A 244
LEU A 249
LEU A 224
 None
 1.44A 3nbqA-3gvpA:
2.8		 3nbqA-3gvpA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 239
ASP A 310
GLU A 335
LYS A 365
 None
 1.48A 3ondA-3gvpA:
45.0		 3ondA-3gvpA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 239
ASP A 310
GLU A 335
LYS A 365
 None
 1.48A 3ondB-3gvpA:
35.5		 3ondB-3gvpA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 239
ASP A 310
GLU A 335
LYS A 365
 None
 1.46A 5axaA-3gvpA:
37.1		 5axaA-3gvpA:
50.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 236
GLN A 238
ASP A 310
LYS A 365
 None
 0.86A 5m66C-3gvpA:
42.4		 5m66C-3gvpA:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 236
GLN A 238
ASP A 310
LYS A 365
 None
 0.82A 5m66D-3gvpA:
42.8		 5m66D-3gvpA:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 239
ASP A 310
GLU A 335
LYS A 365
 None
 1.46A 5m66D-3gvpA:
42.8		 5m66D-3gvpA:
46.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 GLY A 339
HIS A 341
GLN A 366
ALA A 356
VAL A 359
 None
 1.24A 5n0xB-3gvpA:
undetectable		 5n0xB-3gvpA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 239
ASP A 310
GLU A 335
LYS A 365
 None
 1.49A 5v96C-3gvpA:
42.9		 5v96C-3gvpA:
46.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 6 PRO A 603
GLY A 602
ASN A 599
LYS A 600
 None
 0.88A 5xxiA-3gvpA:
undetectable		 5xxiA-3gvpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 6 GLU A 205
ARG A 198
GLU A 200
ALA A 237
 None
 1.14A 6an0A-3gvpA:
3.3		 6an0A-3gvpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 8 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.92A 6cp4A-3gvpA:
undetectable		 6cp4A-3gvpA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		7 / 10 GLY A 399
GLY A 401
GLU A 422
ASP A 424
CYH A 427
THR A 455
ASN A 457
 NAD  A 608 (-3.6A)
NAD  A 608 (-3.4A)
NAD  A 608 (-2.9A)
None
NAD  A 608 (-3.5A)
NAD  A 608 (-4.0A)
NAD  A 608 (-3.8A)
 0.24A 6exiA-3gvpA:
43.4		 6exiA-3gvpA:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		3 / 3 LEU A 588
GLN A 592
LYS A 605
 None
 0.33A 6exiB-3gvpA:
42.6		 6exiB-3gvpA:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		5 / 12 HIS A 234
THR A 236
GLN A 238
THR A 239
LYS A 365
 None
 0.63A 6exiB-3gvpA:
42.6		 6exiB-3gvpA:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		3 / 3 LEU A 588
GLN A 592
LYS A 605
 None
 0.35A 6exiA-3gvpA:
43.4		 6exiA-3gvpA:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		7 / 10 GLY A 399
GLY A 401
GLU A 422
ASP A 424
CYH A 427
THR A 455
ASN A 457
 NAD  A 608 (-3.6A)
NAD  A 608 (-3.4A)
NAD  A 608 (-2.9A)
None
NAD  A 608 (-3.5A)
NAD  A 608 (-4.0A)
NAD  A 608 (-3.8A)
 0.25A 6exiB-3gvpA:
42.6		 6exiB-3gvpA:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		7 / 12 GLY A 399
GLY A 401
GLU A 422
ASP A 424
CYH A 427
THR A 455
ASN A 457
 NAD  A 608 (-3.6A)
NAD  A 608 (-3.4A)
NAD  A 608 (-2.9A)
None
NAD  A 608 (-3.5A)
NAD  A 608 (-4.0A)
NAD  A 608 (-3.8A)
 0.24A 6exiC-3gvpA:
43.3
6exiD-3gvpA:
43.9		 6exiC-3gvpA:
51.25
6exiD-3gvpA:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		7 / 12 GLY A 399
GLY A 401
GLU A 422
ASP A 424
CYH A 427
THR A 455
ASN A 457
 NAD  A 608 (-3.6A)
NAD  A 608 (-3.4A)
NAD  A 608 (-2.9A)
None
NAD  A 608 (-3.5A)
NAD  A 608 (-4.0A)
NAD  A 608 (-3.8A)
 0.25A 6exiC-3gvpA:
43.3
6exiD-3gvpA:
43.9		 6exiC-3gvpA:
51.25
6exiD-3gvpA:
51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens) 		4 / 6 MET A 478
GLY A 404
ALA A 410
LEU A 411
 NAD  A 608 (-4.3A)
None
None
None
 1.06A 6fosA-3gvpA:
undetectable		 6fosA-3gvpA:
11.32