SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLU A  70
ILE A  63
ASP A  64
GLY A  67
ILE A  68
 None
 1.39A 1q8jA-3gvxA:
2.2		 1q8jA-3gvxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A  79
ALA A  80
GLY A 259
GLY A 258
ILE A 267
 None
 0.86A 2fxeA-3gvxA:
undetectable		 2fxeA-3gvxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ALA A 209
GLY A 129
ILE A 127
VAL A 191
VAL A 213
 None
 1.09A 2nnpB-3gvxA:
undetectable		 2nnpB-3gvxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 209
GLY A 129
ILE A 127
VAL A 191
VAL A 213
 None
 1.07A 3nu9B-3gvxA:
undetectable		 3nu9B-3gvxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLU A  70
ILE A  63
ASP A  64
GLY A  67
ILE A  68
 None
 1.30A 4djfA-3gvxA:
undetectable		 4djfA-3gvxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ALA A 138
ALA A 180
GLY A 129
GLY A 132
ILE A 133
 None
 1.15A 4eatB-3gvxA:
6.0		 4eatB-3gvxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 SER A  76
ALA A 268
LEU A 271
PHE A 144
 None
 1.06A 4rkuA-3gvxA:
undetectable
4rkuJ-3gvxA:
undetectable		 4rkuA-3gvxA:
17.66
4rkuJ-3gvxA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ILE A  56
ALA A  17
VAL A  13
VAL A  39
 None
 0.89A 5ecnD-3gvxA:
3.1		 5ecnD-3gvxA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 HIS A  62
ALA A  55
SER A  57
TYR A  81
 None
 1.50A 5yodF-3gvxA:
undetectable		 5yodF-3gvxA:
21.67