SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 8 TYR A 160
LEU A 159
LEU A 153
SER A 152
 None
 0.99A 1i7zA-3gwbA:
undetectable		 1i7zA-3gwbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		3 / 3 ASP A  37
ARG A 100
ASP A 367
 None
 0.76A 1vptA-3gwbA:
undetectable		 1vptA-3gwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 6 LEU A 285
GLY A 277
ASN A 273
ILE A 314
 None
 0.78A 1xf1B-3gwbA:
undetectable		 1xf1B-3gwbA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 11 PRO A 305
MET A 306
THR A 304
GLY A 302
LEU A 159
 None
 1.49A 2uvnB-3gwbA:
undetectable		 2uvnB-3gwbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 7 GLY A 373
ALA A 374
MET A 375
LEU A 380
 None
 0.89A 2wekB-3gwbA:
undetectable		 2wekB-3gwbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LUS_B_X8ZB1001_1
(ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 9 ALA A 255
TYR A 160
PRO A 233
PRO A 236
GLU A 235
 None
 1.41A 3lusA-3gwbA:
1.9
3lusB-3gwbA:
0.0		 3lusA-3gwbA:
17.06
3lusB-3gwbA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 7 LEU A  40
VAL A 197
VAL A 217
LEU A 227
 None
 0.95A 3rgfA-3gwbA:
undetectable		 3rgfA-3gwbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 PHE A  79
ARG A  39
PHE A 115
PHE A  42
ALA A  95
 None
 1.36A 3ua1A-3gwbA:
undetectable		 3ua1A-3gwbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 GLY A 272
ARG A 284
ILE A 275
GLU A 346
VAL A 400
 None
 1.05A 4azsA-3gwbA:
undetectable		 4azsA-3gwbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 GLY A 272
ARG A 284
ILE A 275
GLU A 346
VAL A 400
 None
 1.12A 4azwA-3gwbA:
undetectable		 4azwA-3gwbA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		3 / 3 ASP A  37
ARG A 100
ASP A 367
 None
 0.86A 4fzvA-3gwbA:
undetectable		 4fzvA-3gwbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 PHE A 377
ILE A 230
GLY A  45
ALA A  44
ALA A 226
 None
 0.92A 4nkxB-3gwbA:
undetectable		 4nkxB-3gwbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 6 PHE A 303
ASP A 263
TYR A 266
HIS A 407
 None
 0.97A 4paeA-3gwbA:
0.1		 4paeA-3gwbA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 GLY A  45
ALA A  90
PHE A  42
ALA A  97
VAL A 119
 None
 1.43A 4ryaA-3gwbA:
undetectable		 4ryaA-3gwbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 5 LEU A  63
ALA A  90
VAL A 197
ILE A  41
 None
 0.91A 4xe3B-3gwbA:
undetectable		 4xe3B-3gwbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 ASN A  60
ALA A  44
SER A 175
ILE A 176
MET A 136
 None
 1.17A 5ih0A-3gwbA:
undetectable		 5ih0A-3gwbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		3 / 3 PHE A  36
ASP A 204
LEU A  12
 None
 0.80A 5uhbC-3gwbA:
undetectable		 5uhbC-3gwbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 7 PHE A  79
ALA A 116
GLY A 120
TYR A 192
 None
 0.96A 5uxdA-3gwbA:
undetectable		 5uxdA-3gwbA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 6 GLU A 231
HIS A 163
ALA A 308
GLN A 307
 None
 0.83A 6f6jC-3gwbA:
undetectable
6f6jD-3gwbA:
undetectable		 6f6jC-3gwbA:
22.66
6f6jD-3gwbA:
22.66