SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 6 SER A 171
GLY A 127
THR A 173
ILE A  85
 None
 0.89A 1gtnD-3gweA:
undetectable
1gtnE-3gweA:
undetectable		 1gtnD-3gweA:
11.88
1gtnE-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 7 SER A 171
GLY A 127
THR A 173
ILE A  85
 None
 0.92A 1gtnF-3gweA:
undetectable
1gtnG-3gweA:
undetectable		 1gtnF-3gweA:
11.88
1gtnG-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 7 SER A 171
GLY A 127
THR A 173
ILE A  85
 None
 0.93A 1gtnJ-3gweA:
undetectable
1gtnK-3gweA:
undetectable		 1gtnJ-3gweA:
11.88
1gtnK-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 9 VAL A 117
GLY A 127
THR A 173
ILE A  85
SER A 171
 None
 1.26A 1gtnL-3gweA:
undetectable
1gtnM-3gweA:
undetectable		 1gtnL-3gweA:
11.88
1gtnM-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 4 SER A 122
VAL A 303
PHE A 242
VAL A 247
 None
 1.22A 1o86A-3gweA:
undetectable		 1o86A-3gweA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 8 SER A 171
LEU A 328
TYR A 124
LEU A 320
 None
 0.89A 2bfpB-3gweA:
undetectable		 2bfpB-3gweA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 8 SER A 171
LEU A 328
TYR A 124
LEU A 320
 None
 0.99A 2bfpB-3gweA:
undetectable		 2bfpB-3gweA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 8 SER A 171
LEU A 328
TYR A 124
LEU A 320
 None
 0.99A 2bfpC-3gweA:
undetectable		 2bfpC-3gweA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 11 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.25A 2no6B-3gweA:
undetectable		 2no6B-3gweA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.27A 2noaA-3gweA:
1.1		 2noaA-3gweA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 11 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.23A 2noaB-3gweA:
undetectable		 2noaB-3gweA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		3 / 3 SER A 122
THR A 306
PHE A 292
 None
 0.72A 2x91A-3gweA:
undetectable		 2x91A-3gweA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 7 TYR A 124
SER A 304
ILE A  85
SER A 171
 None
 1.21A 2xz5A-3gweA:
undetectable
2xz5B-3gweA:
undetectable		 2xz5A-3gweA:
19.13
2xz5B-3gweA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 8 TYR A 124
SER A 304
ILE A  85
SER A 171
 None
 1.17A 2xz5B-3gweA:
undetectable
2xz5E-3gweA:
undetectable		 2xz5B-3gweA:
19.13
2xz5E-3gweA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.30A 2ziaA-3gweA:
undetectable		 2ziaA-3gweA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.33A 2ziaB-3gweA:
1.3		 2ziaB-3gweA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 9 VAL A  76
LEU A 128
ILE A  12
ALA A  13
ALA A 131
 None
 1.15A 3mdvA-3gweA:
undetectable		 3mdvA-3gweA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 ILE A  15
ALA A 310
LEU A 311
LEU A 128
GLY A 300
 None
 1.09A 3ozwB-3gweA:
undetectable		 3ozwB-3gweA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 6 GLY A 194
ALA A 197
TYR A 335
GLU A 238
 None
 0.98A 4ae1A-3gweA:
undetectable		 4ae1A-3gweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 7 LEU A  86
THR A 150
ALA A 148
LEU A 146
 None
 0.75A 4d7bA-3gweA:
undetectable		 4d7bA-3gweA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 8 LEU A  86
THR A 150
ALA A 148
LEU A 146
 None
 0.74A 4iizB-3gweA:
undetectable		 4iizB-3gweA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		4 / 8 LEU A  86
THR A 150
ALA A 148
LEU A 146
 None
 0.79A 4ik6B-3gweA:
undetectable		 4ik6B-3gweA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 ALA A 148
THR A 150
THR A  88
LEU A  86
ALA A 172
 None
 0.90A 4ypmA-3gweA:
undetectable		 4ypmA-3gweA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 CYH A 142
ALA A 140
GLY A 133
ASP A  82
ASP A  79
 None
 1.19A 5wwsB-3gweA:
undetectable		 5wwsB-3gweA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		3 / 3 LEU A 155
THR A  45
ASN A 274
 None
 0.72A 6baaE-3gweA:
undetectable		 6baaE-3gweA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		3 / 3 LEU A 155
THR A  45
ASN A 274
 None
 0.72A 6baaF-3gweA:
undetectable		 6baaF-3gweA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		3 / 3 LEU A 155
THR A  45
ASN A 274
 None
 0.73A 6baaG-3gweA:
undetectable		 6baaG-3gweA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		3 / 3 LEU A 155
THR A  45
ASN A 274
 None
 0.73A 6baaH-3gweA:
undetectable		 6baaH-3gweA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III
(Burkholderia
pseudomallei) 		5 / 12 TYR A 124
LEU A 128
ILE A  15
VAL A  76
THR A 147
 None
 1.00A 6djzB-3gweA:
undetectable		 6djzB-3gweA:
25.29