SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1
(Escherichia
coli) 		3 / 3 SER A 453
VAL A 477
LEU A 535
 None
 0.74A 1yajG-3gwiA:
undetectable		 1yajG-3gwiA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1
(Escherichia
coli) 		3 / 3 SER A 432
HIS A 388
ASP A 390
 None
 0.81A 2oxtA-3gwiA:
undetectable		 2oxtA-3gwiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1
(Escherichia
coli) 		4 / 7 ASP A 418
SER A 453
LYS A 468
GLU A 532
 None
 1.14A 3bc9A-3gwiA:
undetectable		 3bc9A-3gwiA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1
(Escherichia
coli) 		3 / 3 SER A 432
SER A 429
HIS A 408
 None
 0.70A 3mzeA-3gwiA:
undetectable		 3mzeA-3gwiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1
(Escherichia
coli) 		4 / 6 ASN A 406
ALA A 403
VAL A 466
ASP A 418
 None
 1.06A 5umd2-3gwiA:
undetectable
5umdF-3gwiA:
undetectable		 5umd2-3gwiA:
15.79
5umdF-3gwiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1
(Escherichia
coli) 		4 / 8 HIS A 388
HIS A 408
ASP A 426
GLU A 428
 None
 1.27A 6mn4C-3gwiA:
undetectable		 6mn4C-3gwiA:
21.37