SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 VAL A  60
ILE A  61
ILE A  79
ILE A 101
VAL A  95
LEU A  97
 VAL  A  60 ( 0.6A)
ILE  A  61 ( 0.7A)
ILE  A  79 (-0.6A)
ILE  A 101 ( 0.7A)
VAL  A  95 ( 0.6A)
LEU  A  97 ( 0.6A)
 1.40A 1qhsA-3gwmA:
undetectable		 1qhsA-3gwmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 VAL A  60
ILE A  61
ILE A  79
ILE A 101
VAL A  95
LEU A  97
 VAL  A  60 ( 0.6A)
ILE  A  61 ( 0.7A)
ILE  A  79 (-0.6A)
ILE  A 101 ( 0.7A)
VAL  A  95 ( 0.6A)
LEU  A  97 ( 0.6A)
 1.46A 1qhyA-3gwmA:
undetectable		 1qhyA-3gwmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A   5
GLU A 129
ILE A 126
ALA A 125
VAL A 124
 GLY  A   5 ( 0.0A)
GLU  A 129 ( 0.6A)
ILE  A 126 ( 0.7A)
ALA  A 125 ( 0.0A)
VAL  A 124 ( 0.6A)
 1.41A 2drdA-3gwmA:
undetectable		 2drdA-3gwmA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 120
ALA A 122
SER A 113
THR A 115
 THR  A 120 ( 0.8A)
ALA  A 122 ( 0.0A)
SER  A 113 ( 0.0A)
THR  A 115 (-0.8A)
 0.82A 4d7bA-3gwmA:
undetectable		 4d7bA-3gwmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 120
ALA A 122
SER A 113
THR A 115
 THR  A 120 ( 0.8A)
ALA  A 122 ( 0.0A)
SER  A 113 ( 0.0A)
THR  A 115 (-0.8A)
 0.79A 4pwjB-3gwmA:
undetectable		 4pwjB-3gwmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 HIS A  80
GLY A  78
GLU A  29
ARG A  81
 HIS  A  80 (-1.0A)
GLY  A  78 (-0.0A)
GLU  A  29 (-0.5A)
ARG  A  81 (-0.6A)
 1.30A 4zbqA-3gwmA:
undetectable		 4zbqA-3gwmA:
14.14