SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A 273
VAL A  71
TRP A  95
 None
 0.95A 1av2C-3gwqA:
undetectable
1av2D-3gwqA:
undetectable		 1av2C-3gwqA:
3.82
1av2D-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 ALA A 311
VAL A  49
TRP A 315
 None
 0.87A 1c4dC-3gwqA:
undetectable
1c4dD-3gwqA:
undetectable		 1c4dC-3gwqA:
3.82
1c4dD-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 TRP A 315
ALA A 311
VAL A  49
 None
 0.79A 1c4dC-3gwqA:
undetectable
1c4dD-3gwqA:
undetectable		 1c4dC-3gwqA:
3.82
1c4dD-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 4 ILE A 329
MET A 390
VAL A  49
GLY A 330
 None
 1.20A 1e06B-3gwqA:
undetectable		 1e06B-3gwqA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A 273
VAL A  71
TRP A  95
 None
 0.88A 1w5uC-3gwqA:
undetectable
1w5uD-3gwqA:
undetectable		 1w5uC-3gwqA:
3.82
1w5uD-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		5 / 9 TYR A  51
LEU A  45
LEU A  38
LEU A  39
ALA A 392
 None
 1.25A 2bxeA-3gwqA:
undetectable		 2bxeA-3gwqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A  71
TRP A  95
VAL A 273
 None
 0.95A 2izqA-3gwqA:
undetectable
2izqB-3gwqA:
undetectable		 2izqA-3gwqA:
3.82
2izqB-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 7 ILE A 367
ILE A 321
LEU A 385
ILE A 379
 None
 0.88A 2q83A-3gwqA:
undetectable		 2q83A-3gwqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 6 ASP A 389
ILE A 391
LEU A 377
GLU A 363
 None
 0.91A 2ya7A-3gwqA:
undetectable		 2ya7A-3gwqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 6 ASP A 389
ILE A 391
LEU A 377
GLU A 363
 None
 0.94A 2ya7B-3gwqA:
undetectable		 2ya7B-3gwqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 6 ASP A 389
ILE A 391
LEU A 377
GLU A 363
 None
 0.93A 2ya7D-3gwqA:
undetectable		 2ya7D-3gwqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 392
ILE A 359
ILE A 379
PRO A 380
ILE A 329
 None
 1.11A 3clbB-3gwqA:
undetectable		 3clbB-3gwqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 7 PHE A 222
GLY A 211
GLY A 177
PHE A 261
 None
 0.91A 3ko0M-3gwqA:
undetectable
3ko0P-3gwqA:
undetectable		 3ko0M-3gwqA:
12.68
3ko0P-3gwqA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A 273
VAL A  71
TRP A  95
 None
 0.85A 3l8lC-3gwqA:
undetectable
3l8lD-3gwqA:
undetectable		 3l8lC-3gwqA:
3.82
3l8lD-3gwqA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		3 / 3 SER A 161
PHE A 159
LYS A 164
 None
 0.92A 3u88A-3gwqA:
undetectable		 3u88A-3gwqA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 6 VAL A 410
ARG A  87
ILE A  97
PHE A  86
 None
GOL  A 426 (-3.6A)
None
None
 1.08A 5jw1B-3gwqA:
undetectable		 5jw1B-3gwqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A  31
VAL A  21
GLY A  17
ALA A  47
LEU A 312
 None
 1.08A 5x23A-3gwqA:
undetectable		 5x23A-3gwqA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3gwq D-SERINE DEAMINASE
(Paraburkholderia
xenovorans) 		4 / 4 ARG A 115
GLU A 141
GLU A 271
ARG A 241
 None
 1.32A 6fk2A-3gwqA:
undetectable		 6fk2A-3gwqA:
14.95