SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 124
VAL A  75
LEU A 139
ALA A 138
ALA A 136
 None
 1.02A 1jinA-3gx8A:
undetectable		 1jinA-3gx8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 136
LEU A 132
VAL A  75
ILE A 120
LEU A  69
 None
 1.33A 3jw3B-3gx8A:
undetectable		 3jw3B-3gx8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.94A 3uboB-3gx8A:
undetectable		 3uboB-3gx8A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4e3aA-3gx8A:
undetectable		 4e3aA-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4jkuB-3gx8A:
undetectable		 4jkuB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4k8pA-3gx8A:
undetectable		 4k8pA-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.98A 4k8pB-3gx8A:
undetectable		 4k8pB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.94A 4k8tA-3gx8A:
undetectable		 4k8tA-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.95A 4k8tB-3gx8A:
undetectable		 4k8tB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4k93A-3gx8A:
undetectable		 4k93A-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.95A 4k93B-3gx8A:
undetectable		 4k93B-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.97A 4k9cA-3gx8A:
undetectable		 4k9cA-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.97A 4k9cB-3gx8A:
undetectable		 4k9cB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4k9iB-3gx8A:
undetectable		 4k9iB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4kadA-3gx8A:
undetectable		 4kadA-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.97A 4kadB-3gx8A:
undetectable		 4kadB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4lbxA-3gx8A:
undetectable		 4lbxA-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4lbxB-3gx8A:
undetectable		 4lbxB-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.96A 4lc4A-3gx8A:
undetectable		 4lc4A-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
GLY A 115
THR A  66
LEU A  70
THR A 103
 None
 0.97A 4lc4B-3gx8A:
undetectable		 4lc4B-3gx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 120
GLY A 115
ILE A  42
LEU A  70
 None
 0.77A 4o8fB-3gx8A:
undetectable		 4o8fB-3gx8A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 THR A  54
ILE A  67
PRO A 105
LEU A  49
 None
 0.83A 5g48A-3gx8A:
undetectable		 5g48A-3gx8A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  80
PRO A  46
VAL A  47
ALA A  81
 None
 1.12A 5t7bA-3gx8A:
undetectable		 5t7bA-3gx8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  82
LEU A  49
VAL A  48
VAL A  85
ILE A 104
 None
 0.91A 5v02B-3gx8A:
undetectable
5v02R-3gx8A:
undetectable		 5v02B-3gx8A:
22.05
5v02R-3gx8A:
23.18