SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 10 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.37A 1a52A-3gxaA:
undetectable		 1a52A-3gxaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 10 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.38A 1a52B-3gxaA:
undetectable		 1a52B-3gxaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 9 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.44A 1ereA-3gxaA:
undetectable		 1ereA-3gxaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 9 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.45A 1ereC-3gxaA:
undetectable		 1ereC-3gxaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 9 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.43A 1ereD-3gxaA:
undetectable		 1ereD-3gxaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 8 ASP A  80
TYR A 216
TYR A 103
HIS A 100
 None
None
MET  A 296 (-3.7A)
MET  A 296 (-3.6A)
 1.40A 2ha2A-3gxaA:
undetectable		 2ha2A-3gxaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 8 ASP A  80
TYR A 216
TYR A 103
HIS A 100
 None
None
MET  A 296 (-3.7A)
MET  A 296 (-3.6A)
 1.36A 2ha2B-3gxaA:
undetectable		 2ha2B-3gxaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 7 LEU A 252
VAL A 255
THR A 256
VAL A 121
 None
 0.92A 2qblA-3gxaA:
undetectable		 2qblA-3gxaA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 6 LEU A 126
GLU A 231
PRO A 232
ARG A 156
 None
None
None
MET  A 296 (-3.2A)
 1.13A 3ltwA-3gxaA:
undetectable		 3ltwA-3gxaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 6 HIS A 100
SER A 152
GLU A 110
ASP A 150
 MET  A 296 (-3.6A)
None
None
None
 1.34A 4blvA-3gxaA:
undetectable		 4blvA-3gxaA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 5 VAL A 157
ARG A 156
MET A 160
GLU A 231
 None
MET  A 296 (-3.2A)
None
None
 1.24A 4hojA-3gxaA:
undetectable		 4hojA-3gxaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 7 SER A 203
GLY A 214
GLY A 127
GLU A 231
 None
 0.94A 4koeA-3gxaA:
undetectable
4koeB-3gxaA:
undetectable
4koeD-3gxaA:
undetectable		 4koeA-3gxaA:
21.96
4koeB-3gxaA:
21.96
4koeD-3gxaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 7 GLY A 214
GLY A 127
GLU A 231
SER A 203
 None
 0.92A 4z53A-3gxaA:
undetectable
4z53B-3gxaA:
undetectable		 4z53A-3gxaA:
19.03
4z53B-3gxaA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 6 SER A 152
PRO A 151
PHE A 154
GLU A 194
 None
 1.28A 5b8iA-3gxaA:
undetectable		 5b8iA-3gxaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 8 ILE A 192
ASN A 213
LEU A 158
LEU A 126
 None
MET  A 296 (-3.9A)
None
None
 0.83A 5y7pE-3gxaA:
undetectable		 5y7pE-3gxaA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 5 ASP A  53
ILE A  62
PHE A 264
TYR A 275
 None
 1.22A 6a93B-3gxaA:
undetectable		 6a93B-3gxaA:
22.08