SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 6 TYR A 252
ASP A 250
VAL A 187
GLY A 248
 None
 1.26A 1ekjC-3gxoA:
2.1
1ekjD-3gxoA:
2.2		 1ekjC-3gxoA:
20.82
1ekjD-3gxoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 6 ASP A 250
VAL A 187
GLY A 248
TYR A 252
 None
 1.24A 1ekjC-3gxoA:
2.2
1ekjD-3gxoA:
2.1		 1ekjC-3gxoA:
20.82
1ekjD-3gxoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 0.99A 1eqhA-3gxoA:
undetectable		 1eqhA-3gxoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.01A 1eqhB-3gxoA:
undetectable		 1eqhB-3gxoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.34A 1hrkB-3gxoA:
3.0		 1hrkB-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 5 PRO A  44
LEU A  47
THR A  55
ARG A  69
 None
 1.33A 1i2wA-3gxoA:
undetectable		 1i2wA-3gxoA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 5 GLU A 235
LEU A 212
LEU A 237
LEU A 211
 None
 0.90A 1np1A-3gxoA:
undetectable		 1np1A-3gxoA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 LEU A 323
VAL A 285
ILE A 254
ALA A 276
ILE A 245
 None
 0.96A 1pbkA-3gxoA:
undetectable		 1pbkA-3gxoA:
15.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		7 / 12 GLY A 190
GLY A 191
GLY A 192
GLU A 213
ASP A 240
PHE A 241
TRP A 261
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.6A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
None
 0.30A 1qzzA-3gxoA:
32.4		 1qzzA-3gxoA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3gxo MMCR
(Streptomyces
lavendulae) 		8 / 12 TRP A 146
GLY A 190
GLY A 191
GLY A 192
GLU A 213
ASP A 240
PHE A 241
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.6A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
None
 0.22A 1xdsA-3gxoA:
34.2		 1xdsA-3gxoA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3gxo MMCR
(Streptomyces
lavendulae) 		8 / 12 TRP A 146
GLY A 190
GLY A 191
GLY A 192
GLU A 213
ASP A 240
PHE A 241
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.6A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
None
 0.59A 1xdsB-3gxoA:
30.8		 1xdsB-3gxoA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3gxo MMCR
(Streptomyces
lavendulae) 		6 / 12 TRP A 146
GLY A 192
GLU A 213
ASP A 240
PHE A 241
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 (-3.6A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
None
 1.06A 1xdsB-3gxoA:
30.8		 1xdsB-3gxoA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 8 GLY A  11
THR A  12
ALA A  13
ALA A  14
 None
 0.48A 2ej3A-3gxoA:
undetectable		 2ej3A-3gxoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.20A 2hrcA-3gxoA:
undetectable		 2hrcA-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.34A 2hrcB-3gxoA:
undetectable		 2hrcB-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.31A 2pnjB-3gxoA:
3.1		 2pnjB-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 5 TYR A 178
ILE A 343
LEU A 196
LEU A 253
 None
 1.00A 2zb7A-3gxoA:
8.3		 2zb7A-3gxoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3gxo MMCR
(Streptomyces
lavendulae) 		3 / 3 MET A 163
GLU A 213
ASP A 240
 SAH  A 350 ( 3.7A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
 0.99A 3a25A-3gxoA:
15.0		 3a25A-3gxoA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.47A 3hcoA-3gxoA:
undetectable		 3hcoA-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.23A 3hcoB-3gxoA:
2.8		 3hcoB-3gxoA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 TRP A 146
MET A 163
GLY A 192
ASP A 260
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 ( 3.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 1.08A 3i5uA-3gxoA:
36.0		 3i5uA-3gxoA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		7 / 12 TRP A 146
PHE A 159
MET A 163
GLY A 191
GLY A 192
ASP A 260
TRP A 261
 SAH  A 350 ( 4.0A)
MQA  A 351 (-4.6A)
SAH  A 350 ( 3.7A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.66A 3i5uA-3gxoA:
36.0		 3i5uA-3gxoA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		6 / 12 TRP A 146
MET A 163
GLY A 191
GLY A 192
ASP A 260
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 ( 3.7A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.64A 3i5uB-3gxoA:
36.0		 3i5uB-3gxoA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 TRP A 146
MET A 163
GLY A 192
ASP A 260
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 ( 3.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 1.05A 3i5uB-3gxoA:
36.0		 3i5uB-3gxoA:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 0.99A 3n8wA-3gxoA:
undetectable		 3n8wA-3gxoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.04A 3n8zA-3gxoA:
undetectable		 3n8zA-3gxoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.02A 3pghC-3gxoA:
undetectable		 3pghC-3gxoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 0.99A 3rr3A-3gxoA:
undetectable		 3rr3A-3gxoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 0.99A 3rr3B-3gxoA:
undetectable		 3rr3B-3gxoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 GLY A 194
VAL A 187
GLY A 164
SER A 167
ASP A 287
 None
None
None
SAH  A 350 (-3.1A)
None
 0.90A 3sueC-3gxoA:
undetectable		 3sueC-3gxoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 GLY A 190
GLY A 192
VAL A 217
PHE A 241
ASP A 260
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
 0.48A 4a6dA-3gxoA:
33.6		 4a6dA-3gxoA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		6 / 12 GLY A 190
GLY A 192
VAL A 217
PHE A 241
ASP A 260
TRP A 261
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.62A 4a6eA-3gxoA:
33.5		 4a6eA-3gxoA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 11 MET A 163
ALA A 171
GLY A 194
ILE A 346
LEU A 323
 SAH  A 350 ( 3.7A)
None
None
None
None
 1.11A 4kt0A-3gxoA:
undetectable
4kt0J-3gxoA:
undetectable		 4kt0A-3gxoA:
19.15
4kt0J-3gxoA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 11 GLY A 190
GLY A 191
VAL A 217
ASP A 240
LYS A 255
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.4A)
SAH  A 350 (-2.6A)
 0.55A 4pghA-3gxoA:
29.1		 4pghA-3gxoA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		7 / 12 SER A 167
ASP A 188
GLY A 190
ASP A 240
LYS A 255
ASP A 260
TRP A 261
 SAH  A 350 (-3.1A)
SAH  A 350 ( 4.9A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.4A)
SAH  A 350 (-2.6A)
MQA  A 351 (-2.8A)
None
 0.63A 4pghB-3gxoA:
30.6		 4pghB-3gxoA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 11 GLY A 190
VAL A 217
ASP A 240
LYS A 255
TRP A 261
 SAH  A 350 (-4.1A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.4A)
SAH  A 350 (-2.6A)
None
 0.58A 4pghC-3gxoA:
28.9		 4pghC-3gxoA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 GLY A 190
GLY A 191
ASP A 240
PHE A 242
LYS A 255
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.4A)
None
SAH  A 350 (-2.6A)
 1.08A 4pghD-3gxoA:
26.3		 4pghD-3gxoA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		6 / 12 SER A 167
GLY A 190
GLY A 191
PHE A 242
LYS A 255
TRP A 261
 SAH  A 350 (-3.1A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
None
SAH  A 350 (-2.6A)
None
 0.73A 4pghD-3gxoA:
26.3		 4pghD-3gxoA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 10 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.01A 4ph9A-3gxoA:
undetectable		 4ph9A-3gxoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 10 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.01A 4ph9B-3gxoA:
undetectable		 4ph9B-3gxoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		3 / 3 GLN A 114
HIS A  36
ARG A  33
 None
 1.09A 4qyqA-3gxoA:
undetectable		 4qyqA-3gxoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		3 / 3 GLN A 114
HIS A  36
ARG A  33
 None
 1.07A 4qyqB-3gxoA:
undetectable		 4qyqB-3gxoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 ALA A 221
GLY A 191
ALA A 162
MET A 163
GLY A 164
 None
SAH  A 350 (-3.6A)
MQA  A 351 (-3.7A)
SAH  A 350 ( 3.7A)
None
 1.22A 4r29A-3gxoA:
undetectable		 4r29A-3gxoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 ALA A 221
GLY A 191
ALA A 162
MET A 163
GLY A 164
 None
SAH  A 350 (-3.6A)
MQA  A 351 (-3.7A)
SAH  A 350 ( 3.7A)
None
 1.06A 4r29B-3gxoA:
undetectable		 4r29B-3gxoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 ALA A 221
GLY A 191
ALA A 162
MET A 163
GLY A 164
 None
SAH  A 350 (-3.6A)
MQA  A 351 (-3.7A)
SAH  A 350 ( 3.7A)
None
 1.16A 4r29C-3gxoA:
undetectable		 4r29C-3gxoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 ALA A 221
GLY A 191
ALA A 162
MET A 163
GLY A 164
 None
SAH  A 350 (-3.6A)
MQA  A 351 (-3.7A)
SAH  A 350 ( 3.7A)
None
 1.07A 4r29D-3gxoA:
undetectable		 4r29D-3gxoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 ILE A 189
GLY A 190
HIS A 256
VAL A 257
ILE A 269
 None
SAH  A 350 (-4.1A)
MQA  A 351 (-3.7A)
SAH  A 350 ( 4.5A)
None
 0.92A 4rvdA-3gxoA:
15.6		 4rvdA-3gxoA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 11 ARG A 282
LEU A 283
GLU A 324
ALA A 320
LEU A 323
 None
 1.18A 4wg0J-3gxoA:
undetectable
4wg0K-3gxoA:
undetectable
4wg0L-3gxoA:
undetectable		 4wg0J-3gxoA:
4.24
4wg0K-3gxoA:
4.24
4wg0L-3gxoA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 11 LEU A 323
VAL A 285
ILE A 254
ALA A 276
ILE A 245
 None
 0.78A 5gpgA-3gxoA:
undetectable		 5gpgA-3gxoA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 LEU A 224
ALA A 186
GLY A 172
ALA A 171
LEU A 168
 None
 1.05A 5jw1B-3gxoA:
undetectable		 5jw1B-3gxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 7 GLY A 190
GLU A 213
ASP A 240
PHE A 241
 SAH  A 350 (-4.1A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
 0.65A 5mvsA-3gxoA:
2.4		 5mvsA-3gxoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3gxo MMCR
(Streptomyces
lavendulae) 		4 / 8 GLY A 190
GLU A 213
ASP A 240
PHE A 241
 SAH  A 350 (-4.1A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
 0.69A 5mvsB-3gxoA:
11.0		 5mvsB-3gxoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 10 MET A 163
ALA A 171
GLY A 194
ILE A 346
LEU A 323
 SAH  A 350 ( 3.7A)
None
None
None
None
 1.14A 5oy01-3gxoA:
undetectable
5oy07-3gxoA:
undetectable		 5oy01-3gxoA:
14.83
5oy07-3gxoA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 GLY A 191
VAL A 217
PHE A 241
ASP A 260
TRP A 261
 SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.36A 5w7pA-3gxoA:
31.5		 5w7pA-3gxoA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 9 LEU A 270
VAL A 266
ILE A 189
PHE A 241
ILE A 254
 None
None
None
SAH  A 350 (-3.6A)
None
 1.23A 5yf9X-3gxoA:
undetectable		 5yf9X-3gxoA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		7 / 12 TRP A 146
GLY A 190
GLY A 192
ARG A 214
PHE A 241
ASP A 260
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.78A 6clxA-3gxoA:
16.4		 6clxA-3gxoA:
39.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 TRP A 146
GLY A 191
PHE A 241
ASP A 260
TRP A 261
 SAH  A 350 ( 4.0A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.76A 6clxA-3gxoA:
16.4		 6clxA-3gxoA:
39.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 9 LEU A 289
SER A 315
PHE A 319
GLU A 318
VAL A 285
 None
 1.49A 6ftpA-3gxoA:
undetectable
6ftpB-3gxoA:
undetectable		 6ftpA-3gxoA:
13.57
6ftpB-3gxoA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3gxo MMCR
(Streptomyces
lavendulae) 		6 / 11 GLY A 190
GLY A 192
VAL A 217
ASP A 240
LYS A 255
ASP A 260
 SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.4A)
SAH  A 350 (-2.6A)
MQA  A 351 (-2.8A)
 0.57A 6i5zD-3gxoA:
29.2		 6i5zD-3gxoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3gxo MMCR
(Streptomyces
lavendulae) 		5 / 12 ASP A 188
GLY A 190
GLY A 192
ASP A 240
PHE A 241
 SAH  A 350 ( 4.9A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
 0.72A 6nj9K-3gxoA:
10.8		 6nj9K-3gxoA:
22.12