SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 5 SER A 240
GLU A 218
TYR A 222
SER A  74
 None
 1.49A 1vidA-3gybA:
4.3		 1vidA-3gybA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 4 THR A 277
THR A 272
ASP A  80
ASP A  87
 None
None
MG  A   1 ( 3.9A)
None
 1.50A 2f8lA-3gybA:
3.3		 2f8lA-3gybA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 12 LEU A 282
LEU A 250
ALA A 252
ALA A 180
LEU A 171
 None
 0.98A 2h42C-3gybA:
undetectable		 2h42C-3gybA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 10 LEU A 182
VAL A 235
ALA A 246
ILE A 266
LEU A 264
 None
 1.20A 3fl9A-3gybA:
undetectable		 3fl9A-3gybA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 10 PRO A 110
SER A 104
LEU A 115
SER A 116
ILE A 122
 None
 1.33A 3iluB-3gybA:
undetectable
3iluE-3gybA:
3.3		 3iluB-3gybA:
21.74
3iluE-3gybA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 9 THR A 272
ALA A 275
LEU A 274
ALA A 246
ASN A  75
 None
 1.47A 3kp6B-3gybA:
undetectable		 3kp6B-3gybA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 12 GLY A 293
SER A 289
ILE A  82
ASN A 288
LEU A 298
 None
MG  A   1 (-2.2A)
None
None
None
 1.18A 3q87B-3gybA:
undetectable		 3q87B-3gybA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 5 HIS A 170
CYH A 327
ILE A 267
LEU A 174
 None
 1.32A 3qpkA-3gybA:
undetectable		 3qpkA-3gybA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 4 ASP A 286
ASP A 287
GLY A 291
THR A 316
 None
MG  A   1 (-2.6A)
None
None
 1.09A 3tl9B-3gybA:
undetectable		 3tl9B-3gybA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 12 LEU A 299
GLY A 144
ALA A 188
ALA A 157
ASN A 158
 None
 1.29A 4pclB-3gybA:
5.2		 4pclB-3gybA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 12 GLY A 144
ASN A 288
ILE A  82
PRO A 273
VAL A  68
 None
 1.01A 4q5mA-3gybA:
undetectable		 4q5mA-3gybA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 6 ALA A 143
GLY A 291
ILE A 123
VAL A  88
 None
 0.71A 4r21A-3gybA:
undetectable		 4r21A-3gybA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 4 ASN A 242
SER A 186
ALA A 216
VAL A 217
 None
 1.40A 4x1kC-3gybA:
2.2		 4x1kC-3gybA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 10 THR A 225
ALA A 246
THR A 245
ALA A 252
GLY A 251
 None
 1.20A 5lf3H-3gybA:
undetectable
5lf3I-3gybA:
undetectable		 5lf3H-3gybA:
20.39
5lf3I-3gybA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 10 THR A 225
ALA A 246
THR A 245
ALA A 252
GLY A 251
 None
 1.20A 5lf3V-3gybA:
undetectable
5lf3W-3gybA:
undetectable		 5lf3V-3gybA:
20.39
5lf3W-3gybA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		5 / 12 VAL A  88
ASP A  87
LEU A 300
ALA A 297
LEU A  81
 None
 1.16A 5nd4B-3gybA:
undetectable		 5nd4B-3gybA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		3 / 3 LEU A 250
THR A 272
ASN A 271
 None
 0.66A 6baaE-3gybA:
undetectable		 6baaE-3gybA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		3 / 3 LEU A 250
THR A 272
ASN A 271
 None
 0.66A 6baaF-3gybA:
undetectable		 6baaF-3gybA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		3 / 3 LEU A 250
THR A 272
ASN A 271
 None
 0.67A 6baaG-3gybA:
undetectable		 6baaG-3gybA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		3 / 3 LEU A 250
THR A 272
ASN A 271
 None
 0.66A 6baaH-3gybA:
undetectable		 6baaH-3gybA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 8 ILE A  66
VAL A  68
PRO A 119
ALA A 125
 None
 0.85A 6cduD-3gybA:
undetectable
6cduE-3gybA:
undetectable		 6cduD-3gybA:
21.66
6cduE-3gybA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)
(Corynebacterium
glutamicum) 		4 / 7 ALA A 125
ILE A  66
VAL A  68
PRO A 119
 None
 0.90A 6cduF-3gybA:
undetectable
6cduJ-3gybA:
undetectable		 6cduF-3gybA:
21.66
6cduJ-3gybA:
21.66