SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		3 / 3 TRP A 193
TYR A 142
LEU A 144
 None
None
EDO  A   5 (-3.9A)
 0.81A 1kxhA-3gycA:
6.9		 1kxhA-3gycA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 5 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.49A 1p6kB-3gycA:
undetectable		 1p6kB-3gycA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 5 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.45A 1rs6B-3gycA:
undetectable		 1rs6B-3gycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 4 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.49A 1zzqA-3gycA:
0.0		 1zzqA-3gycA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 5 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.49A 1zzqB-3gycA:
undetectable		 1zzqB-3gycA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 5 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.45A 1zzuB-3gycA:
undetectable		 1zzuB-3gycA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 8 PHE A 379
PHE A 374
GLN A 106
TYR A 287
 None
 1.07A 2aoxA-3gycA:
0.0		 2aoxA-3gycA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 11 LEU A  69
ILE A 134
ARG A 132
ARG A  75
GLY A  76
 None
 1.34A 2bxmA-3gycA:
undetectable		 2bxmA-3gycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 5 ALA A 360
TRP A 333
LEU A 392
ALA A 361
 None
 1.18A 2jstA-3gycA:
undetectable
2jstB-3gycA:
undetectable		 2jstA-3gycA:
11.45
2jstB-3gycA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 6 ILE A 396
SER A 399
ARG A 362
ILE A 313
 None
 0.99A 2q72A-3gycA:
undetectable		 2q72A-3gycA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 12 TRP A 141
ASN A 186
GLU A 187
HIS A 260
GLU A 331
 None
 0.53A 2v3dA-3gycA:
17.5		 2v3dA-3gycA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 6 SER A 140
VAL A 118
ASP A  83
TRP A  52
 None
 1.46A 2x45A-3gycA:
undetectable		 2x45A-3gycA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 4 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.47A 3n62A-3gycA:
0.0		 3n62A-3gycA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 4 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.47A 3n65A-3gycA:
0.1		 3n65A-3gycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 4 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.48A 3n66A-3gycA:
0.1		 3n66A-3gycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		3 / 3 GLY A 364
TRP A 366
VAL A 369
 None
 0.75A 3n66B-3gycA:
0.1		 3n66B-3gycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_M_CCSM11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 4 LEU A 138
TRP A 163
PHE A 234
PRO A 233
 None
 1.45A 3pqzC-3gycA:
0.0
3pqzM-3gycA:
undetectable		 3pqzC-3gycA:
14.72
3pqzM-3gycA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 8 TRP A 366
VAL A 328
CYH A 332
ILE A  45
 None
 0.96A 4afgD-3gycA:
undetectable
4afgE-3gycA:
undetectable		 4afgD-3gycA:
21.16
4afgE-3gycA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 7 TYR A 181
ASP A 183
SER A 237
TYR A 246
 None
 1.16A 4arcA-3gycA:
undetectable		 4arcA-3gycA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 7 ASP A 242
HIS A 240
VAL A 249
GLU A 248
 None
 1.05A 4hvrA-3gycA:
undetectable		 4hvrA-3gycA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 7 TYR A 246
ASN A 186
GLU A 258
GLU A 187
 None
 1.12A 4mi4A-3gycA:
undetectable
4mi4C-3gycA:
undetectable		 4mi4A-3gycA:
17.62
4mi4C-3gycA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 10 LEU A 126
LEU A 122
LEU A  53
ILE A 179
TRP A 141
 None
 1.39A 4mk4A-3gycA:
undetectable		 4mk4A-3gycA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 10 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.44A 4qvlV-3gycA:
undetectable
4qvlW-3gycA:
0.3		 4qvlV-3gycA:
19.64
4qvlW-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 10 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.45A 4qvwH-3gycA:
undetectable
4qvwI-3gycA:
0.0		 4qvwH-3gycA:
19.64
4qvwI-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 10 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.44A 4qvwV-3gycA:
undetectable
4qvwW-3gycA:
undetectable		 4qvwV-3gycA:
19.64
4qvwW-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 10 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.43A 4qw3H-3gycA:
undetectable
4qw3I-3gycA:
0.0		 4qw3H-3gycA:
19.64
4qw3I-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 11 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.43A 4qw3V-3gycA:
undetectable
4qw3W-3gycA:
0.0		 4qw3V-3gycA:
19.64
4qw3W-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 12 ALA A  79
HIS A 260
GLU A 258
LEU A 419
TYR A 181
 None
 1.45A 4r7lA-3gycA:
undetectable		 4r7lA-3gycA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 11 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.44A 5cz7H-3gycA:
undetectable
5cz7I-3gycA:
0.0		 5cz7H-3gycA:
19.64
5cz7I-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 12 THR A 393
ALA A  44
THR A  46
ALA A 370
CYH A 332
 None
 1.43A 5d0xH-3gycA:
undetectable
5d0xI-3gycA:
undetectable		 5d0xH-3gycA:
19.64
5d0xI-3gycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		3 / 3 TRP A 141
GLU A 331
ASP A 183
 None
 0.91A 5gqbA-3gycA:
6.5		 5gqbA-3gycA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		4 / 5 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.44A 5vunA-3gycA:
undetectable		 5vunA-3gycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		3 / 3 GLY A 364
TRP A 366
VAL A 369
 None
 0.76A 5vuoB-3gycA:
undetectable		 5vuoB-3gycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3gyc PUTATIVE GLYCOSIDE
HYDROLASE
(Parabacteroides
distasonis) 		5 / 10 LEU A 167
LEU A 184
ILE A 179
SER A 139
GLY A 137
 None
 1.13A 6dm0B-3gycA:
undetectable
6dm0C-3gycA:
undetectable		 6dm0B-3gycA:
13.75
6dm0C-3gycA:
13.75