SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 12 ILE A 142
LEU A 136
ASP A  30
GLY A  29
PHE A  28
 None
 1.11A 1axwA-3gydA:
undetectable		 1axwA-3gydA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 12 GLY A  96
LEU A  55
LEU A  54
VAL A  72
ALA A  93
 CMP  A 300 (-3.3A)
CMP  A 300 ( 4.5A)
None
None
None
 1.15A 1gseA-3gydA:
undetectable		 1gseA-3gydA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		3 / 3 GLN A 128
TYR A  38
ARG A  37
 None
 0.85A 1gtbA-3gydA:
undetectable		 1gtbA-3gydA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 11 ILE A  94
GLY A  92
GLU A  20
LYS A  24
GLU A  97
 None
None
None
None
CMP  A 300 (-2.8A)
 1.48A 1n6cA-3gydA:
undetectable		 1n6cA-3gydA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 12 LEU A 129
LEU A 130
TYR A  42
ASP A  62
ASP A 124
 None
 1.32A 3gwuA-3gydA:
undetectable		 3gwuA-3gydA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 10 ALA A  93
VAL A  72
GLY A  96
ALA A  87
VAL A  89
 None
None
CMP  A 300 (-3.3A)
CMP  A 300 (-3.3A)
None
 0.88A 3t3cB-3gydA:
undetectable		 3t3cB-3gydA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 12 ILE A  94
GLY A  92
GLU A  20
LYS A  24
GLU A  97
 None
None
None
None
CMP  A 300 (-2.8A)
 1.23A 4jlgA-3gydA:
undetectable		 4jlgA-3gydA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 10 LEU A  64
GLY A  96
ASP A  62
SER A  99
ALA A 125
 None
CMP  A 300 (-3.3A)
None
CMP  A 300 (-3.3A)
None
 1.17A 4xj7C-3gydA:
undetectable
4xj7D-3gydA:
undetectable		 4xj7C-3gydA:
23.59
4xj7D-3gydA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		4 / 6 PHE A 118
CYH A  45
HIS A  -8
TYR A   2
 None
 1.25A 5ycnA-3gydA:
undetectable		 5ycnA-3gydA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		3 / 3 GLU A  97
LEU A 144
ARG A 143
 CMP  A 300 (-2.8A)
None
None
 0.59A 6d8fA-3gydA:
undetectable		 6d8fA-3gydA:
14.16