SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3gyg NTD BIOSYNTHESIS
OPERON PUTATIVE
HYDROLASE NTDB
(Bacillus
subtilis) 		4 / 8 ILE A  61
HIS A  86
PHE A  87
PHE A  23
 None
 0.93A 2vdbA-3gygA:
undetectable		 2vdbA-3gygA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3gyg NTD BIOSYNTHESIS
OPERON PUTATIVE
HYDROLASE NTDB
(Bacillus
subtilis) 		3 / 3 LEU A  50
TYR A  49
GLN A  52
 None
 0.64A 2wekA-3gygA:
3.7		 2wekA-3gygA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3gyg NTD BIOSYNTHESIS
OPERON PUTATIVE
HYDROLASE NTDB
(Bacillus
subtilis) 		4 / 8 LYS A 209
LEU A 240
ASP A  25
ASP A 232
 None
None
MG  A 301 (-2.6A)
MG  A 301 (-2.7A)
 1.27A 3n2oC-3gygA:
undetectable
3n2oD-3gygA:
undetectable		 3n2oC-3gygA:
18.36
3n2oD-3gygA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gyg NTD BIOSYNTHESIS
OPERON PUTATIVE
HYDROLASE NTDB
(Bacillus
subtilis) 		3 / 3 GLN A  52
GLU A  58
LYS A  53
 None
 1.13A 3su9A-3gygA:
undetectable		 3su9A-3gygA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3gyg NTD BIOSYNTHESIS
OPERON PUTATIVE
HYDROLASE NTDB
(Bacillus
subtilis) 		4 / 8 ASP A 232
ASP A  25
ASP A 236
ILE A 212
 MG  A 301 (-2.7A)
MG  A 301 (-2.6A)
MG  A 301 ( 4.3A)
None
 1.00A 4xjeA-3gygA:
undetectable		 4xjeA-3gygA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3gyg NTD BIOSYNTHESIS
OPERON PUTATIVE
HYDROLASE NTDB
(Bacillus
subtilis) 		4 / 8 ASP A 232
ASP A  25
ASP A 236
ILE A 212
 MG  A 301 (-2.7A)
MG  A 301 (-2.6A)
MG  A 301 ( 4.3A)
None
 1.01A 5cfsA-3gygA:
undetectable		 5cfsA-3gygA:
18.77