SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3gym PROSTASIN
(Homo
sapiens) 		7 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.73A 1aq7A-3gymA:
35.0		 1aq7A-3gymA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3gym PROSTASIN
(Homo
sapiens) 		7 / 9 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.39A 1bcuH-3gymA:
34.4		 1bcuH-3gymA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3gym PROSTASIN
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.53A 1dwcH-3gymA:
33.7		 1dwcH-3gymA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3gym PROSTASIN
(Homo
sapiens) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.66A 1etrH-3gymA:
33.8		 1etrH-3gymA:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.48A 1f5lA-3gymA:
34.5		 1f5lA-3gymA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 3gym PROSTASIN
(Homo
sapiens) 		3 / 3 TRP A 207
TYR A 208
LEU A 134
 None
 1.00A 1kxhA-3gymA:
undetectable		 1kxhA-3gymA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 6 GLY A 142
GLN A 156
VAL A 138
ALA A 190
 None
 0.77A 1p6kA-3gymA:
undetectable		 1p6kA-3gymA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 5 VAL A 138
THR A 139
GLN A  30
ILE A 121
 None
 1.48A 1ss4A-3gymA:
undetectable		 1ss4A-3gymA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.31A 1tnlA-3gymA:
34.8		 1tnlA-3gymA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.25A 2otvA-3gymA:
34.9		 2otvA-3gymA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3gym PROSTASIN
(Homo
sapiens) 		8 / 12 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.36A 2p16A-3gymA:
34.3		 2p16A-3gymA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 12 ILE A 103
ALA A  55
GLY A 196
VAL A  47
GLY A 211
 None
 0.99A 2qe6B-3gymA:
undetectable		 2qe6B-3gymA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 10 TYR A  94
HIS A  91
ALA A  56
ALA A 104
TYR A 234
 None
 1.38A 2r2vC-3gymA:
undetectable
2r2vF-3gymA:
undetectable
2r2vG-3gymA:
undetectable		 2r2vC-3gymA:
8.50
2r2vF-3gymA:
8.50
2r2vG-3gymA:
8.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.48A 2vinA-3gymA:
34.5		 2vinA-3gymA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 3gym PROSTASIN
(Homo
sapiens) 		8 / 12 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.36A 2w26A-3gymA:
34.5		 2w26A-3gymA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 3gym PROSTASIN
(Homo
sapiens) 		7 / 11 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.58A 3gy3A-3gymA:
34.5		 3gy3A-3gymA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 6 GLY A 196
GLN A  30
ILE A 212
VAL A 213
 None
 1.14A 3kvvD-3gymA:
undetectable		 3kvvD-3gymA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 6 GLY A 196
GLN A  30
ILE A 212
VAL A 213
 None
 1.14A 3kvvE-3gymA:
undetectable		 3kvvE-3gymA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 6 GLY A 196
GLN A  30
ILE A 212
VAL A 213
 None
 1.13A 3kvvF-3gymA:
undetectable		 3kvvF-3gymA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.36A 3rxfA-3gymA:
14.8		 3rxfA-3gymA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.29A 3rxhA-3gymA:
35.1		 3rxhA-3gymA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 6 PHE A  58
ALA A 104
GLY A  44
LEU A 106
VAL A  52
 None
 1.29A 4dubB-3gymA:
undetectable		 4dubB-3gymA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3gym PROSTASIN
(Homo
sapiens) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
 0.74A 4fu8A-3gymA:
34.2		 4fu8A-3gymA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3gym PROSTASIN
(Homo
sapiens) 		6 / 12 HIS A  57
ASP A 189
ALA A 190
VAL A 213
TRP A 215
GLY A 226
 None
 0.40A 4hfpD-3gymA:
33.8		 4hfpD-3gymA:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 12 ALA A 126
LEU A 123
ILE A 103
LEU A  53
HIS A  91
 None
 1.24A 4j24D-3gymA:
undetectable		 4j24D-3gymA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3gym PROSTASIN
(Homo
sapiens) 		3 / 3 PRO A 225
VAL A 160
HIS A 135
 None
 0.82A 4pevC-3gymA:
undetectable		 4pevC-3gymA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3gym PROSTASIN
(Homo
sapiens) 		6 / 12 HIS A  57
ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.79A 4rn6B-3gymA:
28.3		 4rn6B-3gymA:
36.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 12 TRP A  27
GLN A  30
ILE A  16
VAL A 160
SER A 200
 None
 1.37A 5l8oB-3gymA:
undetectable		 5l8oB-3gymA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3gym PROSTASIN
(Homo
sapiens) 		5 / 12 LEU A 171
VAL A 184
PRO A 225
THR A 210
GLY A 211
 None
 1.09A 5xiqA-3gymA:
undetectable		 5xiqA-3gymA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 9 ASP A  74
GLY A  44
SER A  54
VAL A  41
ILE A  33
 None
 1.47A 6giqA-3gymA:
undetectable
6giqE-3gymA:
undetectable
6giqI-3gymA:
undetectable		 6giqA-3gymA:
24.30
6giqE-3gymA:
22.43
6giqI-3gymA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 3gym PROSTASIN
(Homo
sapiens) 		5 / 12 LEU A 171
VAL A 184
PRO A 225
THR A 210
GLY A 211
 None
 1.22A 6mn8A-3gymA:
undetectable		 6mn8A-3gymA:
18.54