SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 9 MET A 569
ALA A 575
GLU A 578
LEU A 687
LEU A 667
 None
 1.49A 1ereA-3gyuA:
20.3		 1ereA-3gyuA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 9 MET A 569
ALA A 575
GLU A 578
LEU A 687
LEU A 667
 None
 1.49A 1ereC-3gyuA:
20.2		 1ereC-3gyuA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 8 MET A 569
ALA A 575
GLU A 578
LEU A 687
LEU A 667
 None
 1.49A 1ereE-3gyuA:
20.3		 1ereE-3gyuA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 10 MET A 569
ALA A 575
GLU A 578
LEU A 687
LEU A 667
 None
 1.49A 1pcgB-3gyuA:
20.5		 1pcgB-3gyuA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		4 / 6 LEU A 657
ASN A 655
LEU A 694
ILE A 714
 None
 0.84A 1z95A-3gyuA:
17.8		 1z95A-3gyuA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		3 / 3 ASN A 557
ILE A 621
MET A 625
 None
DL7  A 200 ( 4.5A)
DL7  A 200 ( 4.7A)
 0.71A 2h42C-3gyuA:
undetectable		 2h42C-3gyuA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		4 / 8 SER A 528
LEU A 573
LEU A 664
ASP A 660
 None
 1.01A 2j2pA-3gyuA:
undetectable
2j2pB-3gyuA:
undetectable		 2j2pA-3gyuA:
22.61
2j2pB-3gyuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 12 MET A 569
LEU A 522
LEU A 657
ILE A 598
LEU A 664
 None
 1.11A 2jfaA-3gyuA:
19.5		 2jfaA-3gyuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		4 / 7 ILE A 633
HIS A 643
VAL A 601
PHE A 626
 None
 1.10A 4a97H-3gyuA:
undetectable		 4a97H-3gyuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 9 ILE A 598
PHE A 626
PHE A 623
TRP A 611
VAL A 601
 None
None
None
DL7  A 200 ( 4.2A)
None
 1.49A 4afgA-3gyuA:
0.0
4afgE-3gyuA:
0.0		 4afgA-3gyuA:
23.81
4afgE-3gyuA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		4 / 7 LEU A 657
ASN A 655
LEU A 694
ILE A 714
 None
 0.89A 4okwA-3gyuA:
17.9		 4okwA-3gyuA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		4 / 6 LEU A 573
ASN A 577
MET A 595
LEU A 588
 None
 1.07A 4okxA-3gyuA:
17.9		 4okxA-3gyuA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		4 / 7 VAL A 601
THR A 602
LEU A 721
VAL A 663
 None
 1.02A 5e4dA-3gyuA:
undetectable
5e4dB-3gyuA:
undetectable		 5e4dA-3gyuA:
21.40
5e4dB-3gyuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY
(Strongyloides
stercoralis) 		5 / 12 ALA A 542
MET A 625
ALA A 735
THR A 738
LEU A 556
 None
DL7  A 200 ( 4.7A)
None
None
None
 1.31A 6aycA-3gyuA:
undetectable		 6aycA-3gyuA:
19.07