SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 PHE A  27
THR A 103
VAL A  90
LEU A  52
ILE A 146
 None
APR  A 302 ( 4.2A)
None
None
None
 1.28A 1kqwA-3gz8A:
undetectable		 1kqwA-3gz8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 VAL A  90
LEU A  87
LEU A 145
LEU A 143
GLU A 151
 None
 1.26A 1kw0A-3gz8A:
undetectable		 1kw0A-3gz8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 VAL A  90
LEU A  87
LEU A 145
LEU A 143
GLU A 151
 None
 1.26A 1mmkA-3gz8A:
undetectable		 1mmkA-3gz8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 11 VAL A  90
LEU A  87
LEU A 145
LEU A 143
GLU A 151
 None
 1.31A 1mmtA-3gz8A:
undetectable		 1mmtA-3gz8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 5 LEU A  38
GLY A  51
HIS A 142
ILE A 146
 None
None
APR  A 302 (-4.0A)
None
 0.70A 1xf1A-3gz8A:
undetectable		 1xf1A-3gz8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 6 LEU A  38
GLY A  51
HIS A 142
ILE A 146
 None
None
APR  A 302 (-4.0A)
None
 0.75A 1xf1B-3gz8A:
undetectable		 1xf1B-3gz8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 10 VAL A  39
GLY A  51
VAL A  79
GLN A 113
ILE A 146
 None
 1.30A 3km6A-3gz8A:
undetectable		 3km6A-3gz8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ALA A  97
ASP A  23
ASP A  96
PHE A 140
HIS A 142
 None
APR  A 302 (-2.9A)
APR  A 302 (-3.6A)
APR  A 302 (-3.6A)
APR  A 302 (-4.0A)
 1.45A 3w37A-3gz8A:
undetectable		 3w37A-3gz8A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ALA A  97
ASP A  23
ASP A  96
PHE A 140
HIS A 142
 None
APR  A 302 (-2.9A)
APR  A 302 (-3.6A)
APR  A 302 (-3.6A)
APR  A 302 (-4.0A)
 1.46A 3welA-3gz8A:
undetectable		 3welA-3gz8A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ALA A  97
ASP A  23
ASP A  96
PHE A 140
HIS A 142
 None
APR  A 302 (-2.9A)
APR  A 302 (-3.6A)
APR  A 302 (-3.6A)
APR  A 302 (-4.0A)
 1.50A 3wenA-3gz8A:
undetectable		 3wenA-3gz8A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ALA A  97
ASP A  23
ASP A  96
PHE A 140
HIS A 142
 None
APR  A 302 (-2.9A)
APR  A 302 (-3.6A)
APR  A 302 (-3.6A)
APR  A 302 (-4.0A)
 1.45A 3weoA-3gz8A:
undetectable		 3weoA-3gz8A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 4 TRP A 127
LEU A  26
LEU A  73
THR A  77
 None
 1.48A 4bboD-3gz8A:
undetectable		 4bboD-3gz8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 8 LEU A  26
ALA A  24
LEU A  37
VAL A  22
 None
 0.96A 4iizB-3gz8A:
undetectable		 4iizB-3gz8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 LYS A 126
LYS A  35
TRP A 128
 None
 1.49A 4ji8L-3gz8A:
0.0		 4ji8L-3gz8A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 7 LEU A  73
VAL A  80
PRO A  82
TYR A 106
 None
 1.10A 4lb2A-3gz8A:
undetectable		 4lb2A-3gz8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 GLU A  75
LEU A  70
GLY A  54
LEU A  26
ALA A 108
 None
None
APR  A 302 ( 4.1A)
None
None
 1.25A 5kbwA-3gz8A:
undetectable		 5kbwA-3gz8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 6 LEU A 130
VAL A  36
LEU A  38
VAL A  25
 None
 0.93A 5x7zA-3gz8A:
undetectable		 5x7zA-3gz8A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3gz8 MUTT/NUDIX FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 ARG A  41
PHE A  56
ARG A  98
 APR  A 302 (-3.1A)
APR  A 302 (-3.5A)
APR  A 302 (-2.9A)
 0.90A 5y9yA-3gz8A:
undetectable		 5y9yA-3gz8A:
20.32