SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  69
PHE A 103
VAL A 118
 None
 0.80A 1kijA-3gzaA:
undetectable		 1kijA-3gzaA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 454
GLU A 392
LYS A 425
VAL A 422
 None
 1.15A 1l2iB-3gzaA:
undetectable		 1l2iB-3gzaA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TRP A  81
ILE A 127
LEU A 341
TRP A 120
 None
 1.26A 1q0yH-3gzaA:
undetectable
1q0yL-3gzaA:
undetectable		 1q0yH-3gzaA:
19.19
1q0yL-3gzaA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 282
VAL A 283
PRO A 284
 None
 0.38A 1rg1A-3gzaA:
undetectable		 1rg1A-3gzaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 282
VAL A 283
PRO A 284
 None
 0.40A 1rh0A-3gzaA:
undetectable		 1rh0A-3gzaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 439
SER A 458
TYR A 457
 None
 0.69A 1x70A-3gzaA:
undetectable		 1x70A-3gzaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 426
SER A 421
ARG A 326
GLU A 420
 None
 1.32A 2c8aA-3gzaA:
undetectable		 2c8aA-3gzaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A 250
ASN A 393
ASN A 327
ALA A 447
VAL A 442
 None
 1.24A 2nniA-3gzaA:
undetectable		 2nniA-3gzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 301
THR A 101
ILE A  65
ILE A  70
LEU A 105
 None
 0.98A 2rlcA-3gzaA:
undetectable		 2rlcA-3gzaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A 120
ARG A 121
ASP A 130
ILE A 127
 None
 1.10A 2xadA-3gzaA:
undetectable		 2xadA-3gzaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A 120
ARG A 121
ASP A 130
ILE A 127
 None
 1.09A 2xadB-3gzaA:
undetectable		 2xadB-3gzaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A 120
ARG A 121
ASP A 130
ILE A 127
 None
 1.11A 2xadC-3gzaA:
undetectable		 2xadC-3gzaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A 120
ARG A 121
ASP A 130
ILE A 127
 None
 1.11A 2xadD-3gzaA:
undetectable		 2xadD-3gzaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 151
GLN A 172
ARG A 171
ASN A 111
 None
 0.99A 3kp2A-3gzaA:
undetectable
3kp2B-3gzaA:
undetectable		 3kp2A-3gzaA:
18.48
3kp2B-3gzaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 238
SER A 239
ALA A 287
ILE A 262
LEU A 271
 None
 0.94A 3mb5A-3gzaA:
undetectable		 3mb5A-3gzaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 HIS A  48
ASN A  60
TYR A  55
TYR A 145
 None
None
None
EDO  A 463 (-4.6A)
 1.24A 4a3uA-3gzaA:
8.0		 4a3uA-3gzaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 HIS A  48
ASN A  60
TYR A  55
TYR A 145
 None
None
None
EDO  A 463 (-4.6A)
 1.21A 4a3uB-3gzaA:
7.6		 4a3uB-3gzaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 334
LEU A 291
MET A 353
THR A 289
 None
 1.34A 4do3A-3gzaA:
undetectable		 4do3A-3gzaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A  71
THR A  78
LEU A  95
LEU A 105
 None
 0.87A 4ejgB-3gzaA:
undetectable		 4ejgB-3gzaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 298
GLU A 299
TRP A 300
 None
None
EDO  A 463 ( 3.7A)
 1.16A 5odiD-3gzaA:
undetectable		 5odiD-3gzaA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 298
GLU A 299
TRP A 300
 None
None
EDO  A 463 ( 3.7A)
 1.12A 5odrD-3gzaA:
undetectable		 5odrD-3gzaA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A  48
ASN A  60
TYR A  55
TYR A 145
 None
None
None
EDO  A 463 (-4.6A)
 1.25A 5v4vA-3gzaA:
8.2		 5v4vA-3gzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A  48
ASN A  60
TYR A  55
TYR A 145
 None
None
None
EDO  A 463 (-4.6A)
 1.25A 5v4vB-3gzaA:
7.8		 5v4vB-3gzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A 241
GLY A 237
SER A 239
TRP A 300
VAL A  42
 None
None
None
EDO  A 463 ( 3.7A)
None
 1.12A 6a94B-3gzaA:
undetectable		 6a94B-3gzaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 292
ARG A 297
ASP A 306
 None
 0.82A 6d8pA-3gzaA:
1.9		 6d8pA-3gzaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 288
TYR A 226
ASP A 199
GLU A 100
 EDO  A 463 ( 4.9A)
EPE  A 462 (-4.5A)
None
None
 1.06A 6mn5A-3gzaA:
undetectable		 6mn5A-3gzaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 288
TYR A 226
ASP A 199
GLU A 100
 EDO  A 463 ( 4.9A)
EPE  A 462 (-4.5A)
None
None
 0.92A 6mn5B-3gzaA:
undetectable		 6mn5B-3gzaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3gza PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 288
TYR A 226
ASP A 199
GLU A 100
 EDO  A 463 ( 4.9A)
EPE  A 462 (-4.5A)
None
None
 0.84A 6mn5C-3gzaA:
undetectable		 6mn5C-3gzaA:
11.74