SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 7 GLN C 174
THR C 352
SER C 172
GLN C 241
 None
 1.32A 1eiiA-3gzdC:
undetectable		 1eiiA-3gzdC:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 THR C 187
THR C 188
PRO C 186
 None
 0.84A 1i3wF-3gzdC:
undetectable		 1i3wF-3gzdC:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 THR C 188
PRO C 186
THR C 187
 None
 0.86A 1mnvD-3gzdC:
undetectable		 1mnvD-3gzdC:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 THR C 187
THR C 188
PRO C 186
 None
 0.80A 1mnvD-3gzdC:
undetectable		 1mnvD-3gzdC:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 THR C 187
THR C 188
PRO C 186
 None
 0.84A 1qfiA-3gzdC:
undetectable		 1qfiA-3gzdC:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 12 THR C  96
GLY C  98
ASP C 233
LEU C 248
VAL C 245
 None
PLR  C 500 ( 4.5A)
PLR  C 500 (-2.7A)
None
None
 1.07A 1r30A-3gzdC:
undetectable		 1r30A-3gzdC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		6 / 12 ALA C 437
GLN C 376
LEU C 441
LEU C 374
ALA C 375
ILE C 343
 None
 1.46A 2aclA-3gzdC:
undetectable
2aclE-3gzdC:
undetectable		 2aclA-3gzdC:
21.32
2aclE-3gzdC:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 ARG C 185
THR C 164
LEU C 152
ALA C 162
 None
 1.11A 2e1qD-3gzdC:
undetectable		 2e1qD-3gzdC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 12 LEU C 195
MET C 194
ILE C 193
SER C 210
GLY C 201
 None
 1.22A 2lbdA-3gzdC:
undetectable		 2lbdA-3gzdC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 6 PHE C 260
LEU C 253
ALA C 267
ALA C 309
 None
 0.90A 2vcvB-3gzdC:
undetectable		 2vcvB-3gzdC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 7 PHE C 260
LEU C 253
ALA C 267
ALA C 309
 None
 0.82A 2vcvG-3gzdC:
undetectable		 2vcvG-3gzdC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 6 PHE C 260
LEU C 253
ALA C 267
ALA C 309
 None
 0.92A 2vcvK-3gzdC:
undetectable		 2vcvK-3gzdC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 8 ARG C 185
THR C 164
LEU C 152
ALA C 162
 None
 1.00A 3ax7A-3gzdC:
undetectable		 3ax7A-3gzdC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 9 ARG C 185
THR C 164
LEU C 152
ALA C 161
ALA C 162
 None
 1.02A 3ax7B-3gzdC:
undetectable		 3ax7B-3gzdC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 ALA C  49
LEU C  42
GLY C 262
THR C  96
 None
 0.73A 3dl9A-3gzdC:
undetectable		 3dl9A-3gzdC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 GLN C 174
THR C 175
GLU C 144
HIS C 231
 None
 1.45A 3glqA-3gzdC:
2.4		 3glqA-3gzdC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 8 ARG C 327
VAL C 203
LEU C 355
PRO C 356
 None
 1.06A 3jq7C-3gzdC:
3.2		 3jq7C-3gzdC:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 ASP C 244
ARG C 242
ARG C 271
 None
 0.90A 3k37A-3gzdC:
undetectable		 3k37A-3gzdC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 ILE C 148
HIS C 231
VAL C 106
ASN C 103
 None
None
None
PLR  C 500 ( 4.6A)
 0.92A 3nneA-3gzdC:
0.0		 3nneA-3gzdC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 6 ILE C 148
HIS C 231
VAL C 106
ASN C 103
 None
None
None
PLR  C 500 ( 4.6A)
 1.03A 3nneG-3gzdC:
undetectable		 3nneG-3gzdC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 8 ARG C 185
LEU C 152
ALA C 161
ALA C 162
 None
 0.99A 3ns1L-3gzdC:
undetectable		 3ns1L-3gzdC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 8 ARG C 185
THR C 164
LEU C 152
ALA C 161
 None
 0.87A 3ns1L-3gzdC:
undetectable		 3ns1L-3gzdC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 7 LEU C 152
HIS C 137
VAL C 250
SER C 210
 None
 1.00A 3r9vA-3gzdC:
undetectable
3r9vB-3gzdC:
undetectable		 3r9vA-3gzdC:
21.22
3r9vB-3gzdC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 10 TYR C 261
ASP C  35
ALA C  38
TYR C  36
SER C 417
 None
None
NO3  C 600 (-3.6A)
None
None
 1.32A 3rodC-3gzdC:
undetectable		 3rodC-3gzdC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 11 PHE C 260
ALA C 235
THR C 232
VAL C 243
VAL C 245
 None
PLR  C 500 (-3.5A)
None
None
None
 1.07A 3tmzA-3gzdC:
undetectable		 3tmzA-3gzdC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 7 ARG C 185
THR C 164
LEU C 152
ALA C 162
 None
 1.01A 3uniA-3gzdC:
undetectable		 3uniA-3gzdC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 THR C 188
PRO C 186
THR C 187
 None
 0.88A 4hivD-3gzdC:
undetectable		 4hivD-3gzdC:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 GLY C 365
PRO C 366
GLN C 369
 None
 0.51A 4oltB-3gzdC:
undetectable		 4oltB-3gzdC:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 9 ALA C 410
ALA C 413
SER C 402
LEU C 401
VAL C 399
 None
 1.06A 4or0B-3gzdC:
undetectable		 4or0B-3gzdC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 GLY C 365
PRO C 366
GLN C 369
 None
 0.46A 4qwpB-3gzdC:
undetectable		 4qwpB-3gzdC:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 4 GLY C  98
LEU C 279
PHE C 292
ILE C  94
 PLR  C 500 ( 4.5A)
None
None
None
 0.95A 4xv2A-3gzdC:
undetectable		 4xv2A-3gzdC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 4 GLY C  99
LEU C 279
PHE C 292
ILE C  94
 PLR  C 500 (-3.6A)
None
None
None
 0.92A 4xv2A-3gzdC:
undetectable		 4xv2A-3gzdC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		3 / 3 LEU C 216
VAL C 177
ASP C 178
 None
 0.54A 4y8wC-3gzdC:
undetectable		 4y8wC-3gzdC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 7 SER C  62
THR C 296
GLY C 286
GLY C 287
 None
 0.70A 4yjiA-3gzdC:
undetectable		 4yjiA-3gzdC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 THR C 277
GLY C 272
GLU C 246
ASP C 251
 None
 1.14A 5c0oH-3gzdC:
3.2		 5c0oH-3gzdC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 8 ALA C  38
HIS C 145
ASN C 198
LYS C 259
ARG C 415
 NO3  C 600 (-3.6A)
PLR  C 500 (-3.7A)
NO3  C 600 (-3.5A)
PLR  C 500 (-1.3A)
NO3  C 600 (-3.1A)
 0.63A 5db5A-3gzdC:
40.1
5db5B-3gzdC:
40.0		 5db5A-3gzdC:
27.62
5db5B-3gzdC:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 6 PHE C 292
HIS C 108
PRO C 281
LEU C 283
 None
 1.40A 5dzka-3gzdC:
undetectable
5dzko-3gzdC:
undetectable		 5dzka-3gzdC:
17.61
5dzko-3gzdC:
0.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 PRO C 300
ALA C 303
ALA C  53
ILE C  74
 None
 0.64A 5jncD-3gzdC:
undetectable		 5jncD-3gzdC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 12 LEU C 195
MET C 194
ILE C 193
SER C 210
GLY C 201
 None
 1.05A 5m24A-3gzdC:
undetectable		 5m24A-3gzdC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 6 PHE C 349
PRO C 350
GLY C 351
THR C 352
 None
 0.68A 5x24A-3gzdC:
undetectable		 5x24A-3gzdC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 HIS C 322
TYR C  36
GLY C 419
TYR C 261
 None
 1.22A 5yodH-3gzdC:
undetectable		 5yodH-3gzdC:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		5 / 12 LEU C 253
VAL C 245
GLY C 249
SER C 210
VAL C 106
 None
 1.45A 6a94A-3gzdC:
undetectable		 6a94A-3gzdC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3gzd SELENOCYSTEINE LYASE
(Homo
sapiens) 		4 / 5 ILE C 193
GLN C 174
THR C 175
LEU C 248
 None
 1.02A 6f3mD-3gzdC:
undetectable		 6f3mD-3gzdC:
22.88