SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX8_A_RTLA135_0 (CELLULAR RETINOL-BINDING PROTEIN I, HOLO)	3gzi	TRANSCRIPTIONAL REGULATOR, TETR FAMILY (Shewanella loihica)	5 / 12	PHE A 64 LEU A 63 ALA A 25 LEU A 28 ILE A 39	EDO A 226 ( 4.7A) None None None EDO A 225 (-3.4A)	1.14A	1mx8A-3gziA: undetectable	1mx8A-3gziA: 20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IWM_G_010G6_0 (3C-LIKE PROTEINASE N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE)	3gzi	TRANSCRIPTIONAL REGULATOR, TETR FAMILY (Shewanella loihica)	4 / 4	THR A 97 LEU A 79 MET A 170 ASN A 140	None EDO A 223 ( 4.6A) UNL A 218 (-4.2A) UNL A 218 (-4.1A)	1.46A	3iwmC-3gziA: undetectable	3iwmC-3gziA: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_O_BEZO801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	3gzi	TRANSCRIPTIONAL REGULATOR, TETR FAMILY (Shewanella loihica)	4 / 6	PHE A 174 PRO A 109 MET A 102 LEU A 113	None UNL A 218 ( 4.0A) None None	1.36A	5dzka-3gziA: undetectable 5dzko-3gziA: undetectable	5dzka-3gziA: 24.29 5dzko-3gziA: 2.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX8_A_RTLA135_0","CELLULAR RETINOL-BINDING PROTEIN I, HOLO","3gzi","TRANSCRIPTIONAL REGULATOR, TETR FAMILY","Shewanella loihica",5,"PHE A  64;LEU A  63;ALA A  25;LEU A  28;ILE A  39","EDO A 226 ( 4.7A);None;None;None;EDO A 225 (-3.4A)","1.14A","1mx8A-3gziA:undetectable","1mx8A-3gziA:20.37"],["3IWM_G_010G6_0","3C-LIKE PROTEINASE;N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE","3gzi","TRANSCRIPTIONAL REGULATOR, TETR FAMILY","Shewanella loihica",4,"THR A  97;LEU A  79;MET A 170;ASN A 140","None;EDO A 223 ( 4.6A);UNL A 218 (-4.2A);UNL A 218 (-4.1A)","1.46A","3iwmC-3gziA:undetectable","3iwmC-3gziA:19.87"],["5DZK_O_BEZO801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","3gzi","TRANSCRIPTIONAL REGULATOR, TETR FAMILY","Shewanella loihica",4,"PHE A 174;PRO A 109;MET A 102;LEU A 113","None;UNL A 218 ( 4.0A);None;None","1.36A","5dzka-3gziA:undetectable;5dzko-3gziA:undetectable","5dzka-3gziA:24.29;5dzko-3gziA:2.08"]]