SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		4 / 8 LEU A 258
ALA A 209
ILE A 104
ILE A 261
 None
 0.70A 1d4yB-3gzjA:
undetectable		 1d4yB-3gzjA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		3 / 3 TRP A  24
VAL A  43
TRP A  26
 None
 1.36A 1gmkC-3gzjA:
undetectable
1gmkD-3gzjA:
undetectable		 1gmkC-3gzjA:
5.61
1gmkD-3gzjA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 11 LEU A 164
ALA A 178
MET A 247
GLN A 168
HIS A  86
 None
 1.27A 1hbpA-3gzjA:
undetectable		 1hbpA-3gzjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		4 / 7 VAL A 106
SER A 105
LEU A 258
HIS A  38
 None
 1.04A 2f78A-3gzjA:
undetectable		 2f78A-3gzjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		4 / 7 VAL A 106
SER A 105
LEU A 258
HIS A  38
 None
 1.12A 2f78B-3gzjA:
1.0		 2f78B-3gzjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		4 / 6 VAL A 106
SER A 105
LEU A 258
HIS A  38
 None
 1.10A 2f8dA-3gzjA:
0.8		 2f8dA-3gzjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 12 TYR A 128
ALA A 112
SER A  87
PRO A 124
GLY A  90
 EVS  A1000 (-3.7A)
None
EVS  A1000 (-1.4A)
None
None
 1.26A 2igtC-3gzjA:
2.4		 2igtC-3gzjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 12 GLY A  90
LEU A 187
SER A  87
ALA A 112
SER A 120
 None
EVS  A1000 (-4.6A)
EVS  A1000 (-1.4A)
None
None
 1.32A 2vmyB-3gzjA:
undetectable		 2vmyB-3gzjA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		4 / 8 LEU A  93
PHE A 109
VAL A 206
ALA A 209
 None
 0.95A 3ax9A-3gzjA:
undetectable		 3ax9A-3gzjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		4 / 8 LEU A  93
PHE A 109
VAL A 206
ALA A 209
 None
 0.89A 3uniB-3gzjA:
undetectable		 3uniB-3gzjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 9 PRO A 115
MET A  91
GLU A  98
PHE A  61
LEU A 192
 None
 1.20A 4la0B-3gzjA:
undetectable		 4la0B-3gzjA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 12 GLY A  89
ALA A  42
SER A 105
ILE A 104
MET A  97
 None
 1.03A 5igvA-3gzjA:
undetectable		 5igvA-3gzjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 12 GLY A  90
ALA A  42
SER A 105
ILE A 104
MET A  97
 None
 1.22A 5igvA-3gzjA:
undetectable		 5igvA-3gzjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		5 / 12 LEU A  83
GLY A  85
TYR A 210
TYR A 203
PHE A 198
 None
 1.37A 5kklB-3gzjA:
undetectable		 5kklB-3gzjA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		3 / 3 THR A 200
PRO A 117
ASP A 116
 None
 0.90A 5l8dB-3gzjA:
undetectable		 5l8dB-3gzjA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE
(Rauvolfia
serpentina) 		3 / 3 THR A 200
PRO A 117
ASP A 116
 None
 0.90A 5mwuB-3gzjA:
undetectable		 5mwuB-3gzjA:
19.53