SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 9 VAL A 215
GLY A 225
ASP A 220
PHE A 233
ILE A 154
None
1.08A 1cetA-3gzsA:
undetectable
1cetA-3gzsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 ALA A 373
ALA A 253
LYS A 254
GLU A 258
None
1.21A 1e7cA-3gzsA:
undetectable
1e7cA-3gzsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 6 LEU A 205
ASP A 226
LEU A 198
HIS A 263
None
1.04A 1errB-3gzsA:
undetectable
1errB-3gzsA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 8 LEU A  55
VAL A 215
GLY A 225
GLU A  59
None
1.01A 1jlfA-3gzsA:
undetectable
1jlfB-3gzsA:
undetectable
1jlfA-3gzsA:
21.84
1jlfB-3gzsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 ALA A 250
VAL A 245
TRP A 536
None
None
ACT  A  13 (-4.6A)
0.84A 1micA-3gzsA:
undetectable
1micB-3gzsA:
undetectable
1micA-3gzsA:
2.71
1micB-3gzsA:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 LEU A 160
VAL A 124
TYR A 128
THR A 163
None
1.36A 1nw3A-3gzsA:
undetectable
1nw3A-3gzsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.88A 1rl8A-3gzsA:
undetectable
1rl8A-3gzsA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 8 TYR A 406
PHE A 393
ALA A 317
LEU A 456
None
1.02A 1x8vA-3gzsA:
undetectable
1x8vA-3gzsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 LEU A 525
ASP A 529
ALA A 520
ILE A 521
None
0.84A 2aofB-3gzsA:
undetectable
2aofB-3gzsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 LEU A 525
ASP A 529
ALA A 520
ILE A 521
None
0.78A 2aohB-3gzsA:
undetectable
2aohB-3gzsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.85A 2b7zA-3gzsA:
undetectable
2b7zA-3gzsA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 ARG A 470
GLY A 168
PRO A 169
None
None
ACT  A  13 (-4.0A)
0.67A 2hreD-3gzsA:
undetectable
2hreD-3gzsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 11 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.90A 2idwA-3gzsA:
undetectable
2idwA-3gzsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 LEU A 205
ASP A 226
LEU A 198
HIS A 263
None
1.07A 2jfaA-3gzsA:
undetectable
2jfaA-3gzsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.86A 2nmyB-3gzsA:
undetectable
2nmyB-3gzsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.77A 2nmzA-3gzsA:
undetectable
2nmzA-3gzsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 LEU A 366
GLY A 370
VAL A 245
ALA A 260
MET A 377
None
1.02A 2oz7A-3gzsA:
undetectable
2oz7A-3gzsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 LEU A 205
ASP A 226
LEU A 198
HIS A 263
None
1.08A 2qxsA-3gzsA:
undetectable
2qxsA-3gzsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 LEU A 205
ASP A 226
LEU A 198
HIS A 263
None
1.08A 2qxsB-3gzsA:
undetectable
2qxsB-3gzsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 PHE A 321
SER A 431
PHE A 459
ILE A 433
None
1.10A 2v0mD-3gzsA:
undetectable
2v0mD-3gzsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 TYR A 495
GLU A 448
THR A 442
None
0.67A 2y7hB-3gzsA:
undetectable
2y7hB-3gzsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 7 TYR A 385
ARG A 449
ILE A 389
ASN A 386
None
1.25A 2zseA-3gzsA:
undetectable
2zseA-3gzsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 7 VAL A 175
TYR A 128
ILE A 170
ASP A 185
None
1.16A 3bu1A-3gzsA:
undetectable
3bu1A-3gzsA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 10 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.80A 3ekpB-3gzsA:
undetectable
3ekpB-3gzsA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 10 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.88A 3ekpC-3gzsA:
undetectable
3ekpC-3gzsA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 9 ASP A 419
GLY A 302
ILE A 305
PRO A 430
ALA A 429
None
0.88A 3ektB-3gzsA:
undetectable
3ektB-3gzsA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 LEU A 366
ALA A 257
LEU A 241
MET A 358
LEU A 267
None
1.20A 3erdA-3gzsA:
undetectable
3erdA-3gzsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 7 TYR A 308
TYR A 312
TYR A 406
PHE A 393
None
1.22A 3ku9B-3gzsA:
undetectable
3ku9B-3gzsA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 8 GLU A 369
TYR A 495
ARG A 246
PHE A 247
None
1.20A 3mjrD-3gzsA:
undetectable
3mjrD-3gzsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 LYS A 454
ARG A 244
LEU A 366
None
1.36A 3v4tE-3gzsA:
undetectable
3v4tE-3gzsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 11 GLY A 462
GLU A 464
GLU A 362
ASP A  87
VAL A  82
None
1.14A 4d9hA-3gzsA:
undetectable
4d9hA-3gzsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 11 GLY A 462
GLU A 464
GLU A 362
ASP A  87
VAL A  82
None
1.14A 4danA-3gzsA:
undetectable
4danA-3gzsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 GLY A 462
GLU A 464
GLU A 362
ASP A  87
VAL A  82
None
1.16A 4danA-3gzsA:
undetectable
4danB-3gzsA:
undetectable
4danA-3gzsA:
19.77
4danB-3gzsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 PHE A 459
PHE A 321
ILE A 305
GLY A 302
None
0.94A 4ejjC-3gzsA:
undetectable
4ejjC-3gzsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 GLU A 464
LEU A 241
ARG A 244
ILE A 154
LEU A 198
None
1.08A 4j24D-3gzsA:
undetectable
4j24D-3gzsA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 6 TYR A 191
GLU A 468
THR A 467
LEU A 241
None
1.24A 4qzuC-3gzsA:
undetectable
4qzuC-3gzsA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
4 / 5 VAL A  75
ILE A 451
PRO A 460
THR A 304
None
None
ACT  A   8 ( 4.1A)
None
1.29A 4ze1A-3gzsA:
undetectable
4ze1A-3gzsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 GLU A 468
TRP A 466
ASN A 461
None
None
ACT  A   8 (-3.6A)
1.06A 5dv4A-3gzsA:
undetectable
5dv4A-3gzsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 11 ALA A 403
ALA A 387
GLY A 388
ASP A 314
LEU A 309
None
OCS  A 364 ( 3.6A)
OCS  A 364 ( 3.6A)
None
None
1.13A 5lf7H-3gzsA:
undetectable
5lf7I-3gzsA:
undetectable
5lf7H-3gzsA:
19.38
5lf7I-3gzsA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
5 / 12 GLU A 464
LEU A 241
ARG A 244
ILE A 154
LEU A 198
None
1.13A 5toaB-3gzsA:
undetectable
5toaB-3gzsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 VAL A 124
TYR A 128
GLU A 509
None
0.84A 5zmqD-3gzsA:
undetectable
5zmqE-3gzsA:
undetectable
5zmqD-3gzsA:
18.47
5zmqE-3gzsA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis)
3 / 3 GLU A 351
ASP A 353
PRO A 354
None
0.78A 6berA-3gzsA:
undetectable
6berA-3gzsA:
4.15