SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		4 / 7 ARG A 133
ASP A  10
GLY A  20
ILE A 142
 None
MG  A 501 (-4.5A)
None
None
 0.90A 2fxdB-3h08A:
undetectable		 2fxdB-3h08A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		5 / 12 THR A  42
SER A  69
THR A   9
GLY A  21
ALA A  12
 None
MG  A 501 (-3.4A)
None
None
None
 1.26A 2x2iA-3h08A:
undetectable		 2x2iA-3h08A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		5 / 12 THR A  42
SER A  71
SER A  69
THR A   9
GLY A  21
 None
MG  A 501 ( 4.8A)
MG  A 501 (-3.4A)
None
None
 1.13A 2x2iA-3h08A:
undetectable		 2x2iA-3h08A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		5 / 12 THR A  42
SER A  71
SER A  69
THR A   9
GLY A  21
 None
MG  A 501 ( 4.8A)
MG  A 501 (-3.4A)
None
None
 1.16A 2x2iC-3h08A:
undetectable		 2x2iC-3h08A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		4 / 7 ILE A 108
SER A  69
TYR A  73
TRP A 105
 None
MG  A 501 (-3.4A)
None
None
 1.14A 2xz5D-3h08A:
undetectable
2xz5E-3h08A:
undetectable		 2xz5D-3h08A:
18.35
2xz5E-3h08A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		5 / 12 ILE A  35
ALA A 134
ALA A  52
ILE A   5
LEU A  59
 None
 1.02A 3dauA-3h08A:
undetectable		 3dauA-3h08A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		4 / 8 ARG A 133
ASP A  10
GLY A  20
ILE A 142
 None
MG  A 501 (-4.5A)
None
None
 0.84A 3el9A-3h08A:
undetectable		 3el9A-3h08A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		5 / 12 GLY A  23
GLY A  21
LEU A 137
GLU A  48
ALA A  51
 None
None
None
MG  A 501 (-4.7A)
None
 1.05A 3kkzA-3h08A:
undetectable		 3kkzA-3h08A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3h08 RNH (RIBONUCLEASE H)
(Chlorobaculum
tepidum) 		4 / 4 LYS A  84
GLN A 106
ILE A  53
LEU A  67
 None
 1.38A 3qt0A-3h08A:
undetectable		 3qt0A-3h08A:
18.38