SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h0g'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4G_B_ZMRB466_2 (NEURAMINIDASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASP A 259 ARG B 924 ILE B 907	None	0.65A	1a4gB-3h0gA: undetectable	1a4gB-3h0gA: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_B_ADNB602_1 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	ASP B 987 HIS B1065 LEU A 664 GLY B 821 MET B 981	None	1.41A	1d4fB-3h0gB: undetectable	1d4fB-3h0gB: 14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DTL_A_BEPA206_1 (CARDIAC TROPONIN C)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	GLN K   3 PRO K   4 ASP B1089 ARG B 961	None	1.15A	1dtlA-3h0gK: undetectable	1dtlA-3h0gK: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DVT_A_FLPA125_1 (TRANSTHYRETIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 (Schizosaccharomy ces pombe)	4 / 8	LEU D  15 ALA D  10 LEU D 111 SER D 110	None	0.96A	1dvtA-3h0gD: undetectable 1dvtB-3h0gD: undetectable	1dvtA-3h0gD: 20.55 1dvtB-3h0gD: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_A_HLTA4001_1 (SERUM ALBUMIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (Schizosaccharomy ces pombe)	4 / 5	ARG L  63 LYS C 170 ASP C  46 GLY C 163	None	0.93A	1e7bA-3h0gL: undetectable	1e7bA-3h0gL: 7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_B_HLTB4001_1 (SERUM ALBUMIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (Schizosaccharomy ces pombe)	4 / 4	ARG L  63 LYS C 170 ASP C  46 GLY C 163	None	1.03A	1e7bB-3h0gL: undetectable	1e7bB-3h0gL: 7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_E_CUE3_0 (BETA-CARBONIC ANHYDRASE)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 6	CYH J   7 SER J   9 CYH J  44 ARG J  47	ZN  J1066 (-2.2A) ZN  J1066 (-2.9A) ZN  J1066 (-2.1A) None	1.39A	1ekjE-3h0gJ: undetectable 1ekjF-3h0gJ: undetectable	1ekjE-3h0gJ: 15.38 1ekjF-3h0gJ: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKJ_A_FK5A108_1 (FK506 BINDING PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe)	5 / 11	ASP H  41 VAL A 570 ILE A 571 TYR H  74 PHE A 546	None	1.29A	1fkjA-3h0gH: undetectable	1fkjA-3h0gH: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM9_A_9CRA201_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.89A	1fm9A-3h0gK: undetectable	1fm9A-3h0gK: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_E_TRPE81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 6	THR A 357 GLY B 966 THR A 360 ILE B 965	None	0.92A	1gtnD-3h0gA: undetectable 1gtnE-3h0gA: undetectable	1gtnD-3h0gA: 3.79 1gtnE-3h0gA: 3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK1_A_T44A3004_1 (SERUM ALBUMIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	GLU A1199 LEU A1200 VAL A1215 MET A1212	None	1.03A	1hk1A-3h0gA: undetectable	1hk1A-3h0gA: 16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_A_CHDA1502_0 (FERROCHELATASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	LEU B 402 PRO B 487 VAL B 465 GLY B 464	None	1.05A	1hrkA-3h0gB: undetectable	1hrkA-3h0gB: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2502_0 (FERROCHELATASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	LEU B 402 PRO B 487 VAL B 465 GLY B 464	None	1.02A	1hrkB-3h0gB: undetectable	1hrkB-3h0gB: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_A_115A2_2 (HMG-COA REDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	4 / 8	GLU K  37 LEU C 256 ALA K  90 LEU K  93	None	1.04A	1hwiB-3h0gK: 2.7	1hwiB-3h0gK: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I9G_A_SAMA301_0 (HYPOTHETICAL PROTEIN RV2118C)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	GLY J  32 GLY B1028 SER B1024 LEU B1026 LEU J  24	None	1.28A	1i9gA-3h0gJ: undetectable	1i9gA-3h0gJ: 15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_A_NIOA221_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	SER A 799 PHE A 793 PHE A 821 GLU A 801	None	1.06A	1icuA-3h0gA: undetectable 1icuB-3h0gA: undetectable	1icuA-3h0gA: 9.61 1icuB-3h0gA: 9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_B_NIOB219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	PHE A 821 GLU A 801 SER A 799 PHE A 793	None	1.09A	1icuA-3h0gA: undetectable 1icuB-3h0gA: undetectable	1icuA-3h0gA: 9.61 1icuB-3h0gA: 9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IG3_B_VIBB501_1 (THIAMIN PYROPHOSPHOKINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 7	GLN J  41 SER C 235 SER C  16 ASN C  15	None	1.25A	1ig3A-3h0gJ: undetectable 1ig3B-3h0gJ: undetectable	1ig3A-3h0gJ: 13.39 1ig3B-3h0gJ: 13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JU6_B_LYAB315_1 (THYMIDYLATE SYNTHASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (Schizosaccharomy ces pombe)	5 / 9	ILE B 900 ASP B 885 LEU B 887 GLY B 886 TYR L  22	None	1.50A	1ju6B-3h0gB: undetectable	1ju6B-3h0gB: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JU6_C_LYAC315_1 (THYMIDYLATE SYNTHASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (Schizosaccharomy ces pombe)	5 / 10	ILE B 900 ASP B 885 LEU B 887 GLY B 886 TYR L  22	None	1.49A	1ju6C-3h0gB: undetectable	1ju6C-3h0gB: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JU6_D_LYAD315_1 (THYMIDYLATE SYNTHASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (Schizosaccharomy ces pombe)	5 / 11	ILE B 900 ASP B 885 LEU B 887 GLY B 886 TYR L  22	None	1.50A	1ju6D-3h0gB: undetectable	1ju6D-3h0gB: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K74_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.91A	1k74A-3h0gK: undetectable	1k74A-3h0gK: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_A_BEZA524_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	SER A 799 PHE A 793 PHE A 821 GLU A 801	None	1.03A	1kqbA-3h0gA: undetectable 1kqbB-3h0gA: undetectable	1kqbA-3h0gA: 9.43 1kqbB-3h0gA: 9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_C_BEZC522_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	SER A 799 PHE A 793 PHE A 821 GLU A 801	None	1.11A	1kqbC-3h0gA: undetectable 1kqbD-3h0gA: undetectable	1kqbC-3h0gA: 9.43 1kqbD-3h0gA: 9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_D_BEZD523_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	PHE A 821 GLU A 801 SER A 799 PHE A 793	None	1.08A	1kqbC-3h0gA: undetectable 1kqbD-3h0gA: undetectable	1kqbC-3h0gA: 9.43 1kqbD-3h0gA: 9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N4F_A_ASRA140_0 (LYSOZYME C)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	3 / 3	ASN A 550 ALA K  46 ASN K  43	None	0.74A	1n4fA-3h0gA: undetectable	1n4fA-3h0gA: 5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 12	PHE A  93 LEU A 302 LEU A 211 PRO A 210 LEU A 208	None	1.13A	1og5A-3h0gA: undetectable	1og5A-3h0gA: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OQ5_A_CELA701_2 (CARBONIC ANHYDRASE II)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 (Schizosaccharomy ces pombe)	4 / 4	HIS I  60 VAL I  58 THR I  64 LEU I  68	None	1.44A	1oq5A-3h0gI: undetectable	1oq5A-3h0gI: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 8	SER B 834 ARG B 837 PHE J   8 ASN B 831	None	1.22A	1p6kB-3h0gB: undetectable	1p6kB-3h0gB: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS6_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 8	SER B 834 ARG B 837 PHE J   8 ASN B 831	None	1.32A	1rs6A-3h0gB: undetectable	1rs6A-3h0gB: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS6_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 8	SER B 834 ARG B 837 PHE J   8 ASN B 831	None	1.30A	1rs6B-3h0gB: undetectable	1rs6B-3h0gB: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS7_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 8	SER B 834 ARG B 837 PHE J   8 ASN B 831	None	1.17A	1rs7B-3h0gB: undetectable	1rs7B-3h0gB: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SDT_B_MK1B902_1 (PROTEASE RETROPEPSIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 10	LEU A 370 ILE B 965 GLY B 966 PRO A 373 VAL A 372	None	0.85A	1sdtA-3h0gA: undetectable	1sdtA-3h0gA: 7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TDN_A_LEUA487_0 (L-AMINO ACID OXIDASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	ASN B1199 HIS A  94 PHE A  97 ILE A 331	None	1.28A	1tdnA-3h0gB: undetectable	1tdnA-3h0gB: 16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V55_P_CHDP4271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE III CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	LYS G   3 LEU G   5 PHE A1496 LEU G  50	None	0.87A	1v55P-3h0gG: undetectable 1v55W-3h0gG: undetectable	1v55P-3h0gG: 22.22 1v55W-3h0gG: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_1 (DIPEPTIDYL PEPTIDASE IV)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	SER B  29 PHE B  36 TYR B 676 TYR B 530 VAL B 669	None	1.48A	1x70A-3h0gB: undetectable	1x70A-3h0gB: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_A_9CRA801_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.93A	1xlsA-3h0gK: undetectable	1xlsA-3h0gK: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_B_9CRB802_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.92A	1xlsB-3h0gK: undetectable	1xlsB-3h0gK: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_C_9CRC803_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.93A	1xlsC-3h0gK: undetectable	1xlsC-3h0gK: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_D_9CRD804_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.92A	1xlsD-3h0gK: undetectable	1xlsD-3h0gK: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XMU_B_ROFB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe)	4 / 5	ASN H  37 THR H  39 MET H 102 PHE H  11	None	1.26A	1xmuB-3h0gH: undetectable	1xmuB-3h0gH: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZX_X_T3X500_2 (THYROID HORMONE RECEPTOR BETA-1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	PHE B1119 ARG A 452 ASN A 494	None	0.79A	1xzxX-3h0gB: undetectable	1xzxX-3h0gB: 12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_A_H4BA760_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 7	VAL B 685 ARG B 590 VAL B 602 GLU B 682	None	1.17A	1zzuA-3h0gB: 0.4 1zzuB-3h0gB: undetectable	1zzuA-3h0gB: 15.29 1zzuB-3h0gB: 15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 8	SER B 834 ARG B 837 PHE J   8 ASN B 831	None	1.21A	1zzuB-3h0gB: undetectable	1zzuB-3h0gB: 15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_A_REAA502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 12	GLN A 582 ASN A 615 LEU A 584 ILE A 639 LEU A 594	None	0.95A	2aclA-3h0gA: undetectable 2aclE-3h0gA: undetectable	2aclA-3h0gA: 11.34 2aclE-3h0gA: 11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_G_REAG501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.91A	2aclG-3h0gK: undetectable	2aclG-3h0gK: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYS_C_CHDC310_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	LYS G   3 LEU G   5 PHE A1496 LEU G  50	None	0.91A	2dysC-3h0gG: undetectable 2dysJ-3h0gG: undetectable	2dysC-3h0gG: 22.22 2dysJ-3h0gG: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIJ_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	LYS G   3 LEU G   5 PHE A1496 LEU G  50	None	0.86A	2eijP-3h0gG: undetectable 2eijW-3h0gG: undetectable	2eijP-3h0gG: 22.22 2eijW-3h0gG: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_A_SAMA2001_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe)	5 / 12	ASP E  24 VAL E  22 HIS E  23 PHE E  59 VAL E  29	None	1.45A	2g72A-3h0gE: undetectable	2g72A-3h0gE: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GL0_B_ADNB902_1 (CONSERVED HYPOTHETICAL PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe)	5 / 11	PHE G 100 ILE G 138 ALA G  90 ASN G 103 VAL G 116	None	1.35A	2gl0B-3h0gG: undetectable 2gl0C-3h0gG: undetectable	2gl0B-3h0gG: 24.88 2gl0C-3h0gG: 24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_A_EAAA0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 8	VAL C 236 TRP C 171 ILE J   5 GLY J  11	None	0.66A	2gssA-3h0gC: undetectable	2gssA-3h0gC: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_B_EAAB0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 8	VAL C 236 TRP C 171 ILE J   5 GLY J  11	None	0.66A	2gssB-3h0gC: undetectable	2gssB-3h0gC: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HA2_A_SCKA901_1 (ACETYLCHOLINESTERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	4 / 8	TYR C 181 ASP C 182 TYR B1062 TYR C 192	None	1.23A	2ha2A-3h0gC: undetectable	2ha2A-3h0gC: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HA2_B_SCKB951_1 (ACETYLCHOLINESTERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	4 / 8	TYR C 181 ASP C 182 TYR B1062 TYR C 192	None	1.26A	2ha2B-3h0gC: undetectable	2ha2B-3h0gC: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRE_D_CHDD702_0 (FERROCHELATASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	ARG A1055 GLY A 644 PRO A 645	None	0.33A	2hreD-3h0gA: undetectable	2hreD-3h0gA: 12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_B_SC2B1290_1 (FICOLIN-2)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	SER B 446 LEU B 443 LEU B 406 ASP B 454	None	0.74A	2j2pA-3h0gB: undetectable 2j2pB-3h0gB: undetectable	2j2pA-3h0gB: 10.28 2j2pB-3h0gB: 10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OUZ_A_C3DA999_1 (ESTROGEN RECEPTOR)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 6	ALA G  33 ASP G  34 GLU G  36 ARG D  41	None	1.14A	2ouzA-3h0gG: undetectable	2ouzA-3h0gG: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PCP_B_1PCB227_1 (IMMUNOGLOBULIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe)	5 / 9	TYR A 434 GLY A 435 TYR G  18 HIS G  15 SER G  17	None	1.39A	2pcpA-3h0gA: 0.0 2pcpB-3h0gA: 0.0	2pcpA-3h0gA: 7.67 2pcpB-3h0gA: 7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD4_A_CHDA801_0 (FERROCHELATASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	LEU B 801 LEU B 527 GLN B1082 PRO B 510 VAL B 508	None	1.35A	2qd4A-3h0gB: undetectable	2qd4A-3h0gB: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD4_B_CHDB928_0 (FERROCHELATASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	LEU B 801 LEU B 527 GLN B1082 PRO B 510 VAL B 508	None	1.22A	2qd4B-3h0gB: undetectable	2qd4B-3h0gB: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_B_MK1B902_1 (PROTEASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	LEU A 370 ILE B 965 GLY B 966 PRO A 373 VAL A 372	None	0.85A	2r5pA-3h0gA: undetectable	2r5pA-3h0gA: 4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_D_MK1D902_1 (PROTEASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	LEU A 370 ILE B 965 GLY B 966 PRO A 373 VAL A 372	None	0.85A	2r5pC-3h0gA: undetectable	2r5pC-3h0gA: 4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RHM_B_BEZB194_0 (PUTATIVE KINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 5	PRO G  64 ILE A1449 ARG G  61 ASP A1448	None	0.88A	2rhmB-3h0gG: undetectable	2rhmB-3h0gG: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RHM_D_BEZD194_0 (PUTATIVE KINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 5	PRO G  64 ILE A1449 ARG G  61 ASP A1448	None	0.99A	2rhmD-3h0gG: undetectable	2rhmD-3h0gG: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VN1_B_FK5B501_1 (70 KDA PEPTIDYLPROLYL ISOMERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe)	5 / 10	ASP H  41 VAL A 570 ILE A 571 TYR H  74 PHE A 546	None	1.37A	2vn1B-3h0gH: undetectable	2vn1B-3h0gH: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_B_TOPB1160_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 11	ILE B 255 ALA B 257 LEU B 364 ILE B 368 ILE B 283	None	1.08A	2w9sB-3h0gB: undetectable	2w9sB-3h0gB: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7K_C_SALC1302_1 (LYSR-TYPE REGULATORY PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe)	5 / 12	THR G 153 ILE G 158 GLY G  41 PHE D  19 PRO G  82	None	1.34A	2y7kC-3h0gG: undetectable	2y7kC-3h0gG: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z0A_C_GLYC73_0 (NONSTRUCTURAL PROTEIN 1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 4	ASP A 798 ASP A 797 SER A 802 ARG A 803	None	1.40A	2z0aC-3h0gA: 2.4	2z0aC-3h0gA: 4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZXW_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	LYS G   3 LEU G   5 PHE A1496 LEU G  50	None	0.88A	2zxwC-3h0gG: undetectable 2zxwJ-3h0gG: undetectable	2zxwC-3h0gG: 22.22 2zxwJ-3h0gG: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABK_W_CHDW1059_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 5	ILE A1107 ARG A1351 MET A1381 THR A1382	None	1.35A	3abkN-3h0gA: undetectable 3abkW-3h0gA: undetectable	3abkN-3h0gA: 13.51 3abkW-3h0gA: 3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIC_A_ACRA5044_2 (GLUCOSYLTRANSFERASE- SI)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B  30 TRP B 665 TYR B 800	None	0.95A	3aicA-3h0gB: undetectable	3aicA-3h0gB: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIC_B_ACRB5044_2 (GLUCOSYLTRANSFERASE- SI)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B  30 TRP B 665 TYR B 800	None	0.96A	3aicB-3h0gB: undetectable	3aicB-3h0gB: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIC_E_ACRE5044_2 (GLUCOSYLTRANSFERASE- SI)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B  30 TRP B 665 TYR B 800	None	0.93A	3aicE-3h0gB: undetectable	3aicE-3h0gB: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIC_F_ACRF5044_2 (GLUCOSYLTRANSFERASE- SI)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B  30 TRP B 665 TYR B 800	None	0.92A	3aicF-3h0gB: undetectable	3aicF-3h0gB: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIC_G_ACRG5044_2 (GLUCOSYLTRANSFERASE- SI)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B  30 TRP B 665 TYR B 800	None	0.94A	3aicG-3h0gB: undetectable	3aicG-3h0gB: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIC_H_ACRH5044_2 (GLUCOSYLTRANSFERASE- SI)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B  30 TRP B 665 TYR B 800	None	0.92A	3aicH-3h0gB: undetectable	3aicH-3h0gB: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CCF_B_BEZB261_0 (CYCLOPROPANE-FATTY-A CYL-PHOSPHOLIPID SYNTHASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	ILE B 674 TRP B 665 PHE B  24 TYR B 676	None	0.95A	3ccfB-3h0gB: undetectable	3ccfB-3h0gB: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CR5_X_PNTX95_0 (PROTEIN S100-B)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	CYH A 648 PHE A 651 PHE A 652	None	0.67A	3cr5X-3h0gA: undetectable	3cr5X-3h0gA: 5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D4S_A_TIMA401_2 (BETA-2 ADRENERGIC RECEPTOR/T4-LYSOZYME CHIMERA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	THR B 795 SER B 797 PHE B1036	None	0.83A	3d4sA-3h0gB: undetectable	3d4sA-3h0gB: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9X_A_NIMA1_1 (LACTOTRANSFERRIN')	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 4	GLU B 249 GLY A1271 THR A1268 GLU A1270	None	1.26A	3e9xA-3h0gB: undetectable	3e9xA-3h0gB: 14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_C_SAMC300_1 (PUTATIVE RRNA METHYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASN B 191 ASP B 454 GLN B 455	None	0.82A	3eeyC-3h0gB: undetectable	3eeyC-3h0gB: 10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_D_SAMD300_1 (PUTATIVE RRNA METHYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASN B 191 ASP B 454 GLN B 455	None	0.81A	3eeyD-3h0gB: undetectable	3eeyD-3h0gB: 10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_1 (PUTATIVE RRNA METHYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASN B 191 ASP B 454 GLN B 455	None	0.82A	3eeyE-3h0gB: undetectable	3eeyE-3h0gB: 10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKY_A_DR7A100_2 (PROTEASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	ASP A 446 GLY A 463 ILE A 449 VAL A 372 ILE A 466	None	1.18A	3ekyB-3h0gA: undetectable	3ekyB-3h0gA: 7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_A_TRPA1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 10	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.03A	3fhjA-3h0gA: undetectable	3fhjA-3h0gA: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_B_TRPB1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 10	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.03A	3fhjB-3h0gA: undetectable	3fhjB-3h0gA: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_C_TRPC1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 10	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.04A	3fhjC-3h0gA: undetectable	3fhjC-3h0gA: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_D_TRPD1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.03A	3fhjD-3h0gA: undetectable	3fhjD-3h0gA: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_E_TRPE1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 10	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.03A	3fhjE-3h0gA: undetectable	3fhjE-3h0gA: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_F_TRPF1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.03A	3fhjF-3h0gA: undetectable	3fhjF-3h0gA: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_A_TRPA1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.98A	3fi0A-3h0gA: undetectable	3fi0A-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_C_TRPC1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.97A	3fi0C-3h0gA: undetectable	3fi0C-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_D_TRPD1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.98A	3fi0D-3h0gA: undetectable	3fi0D-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_E_TRPE1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 7	GLY A1068 HIS A1373 VAL A 856 GLN A 871	None	0.83A	3fi0E-3h0gA: undetectable	3fi0E-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_F_TRPF1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.96A	3fi0F-3h0gA: undetectable	3fi0F-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_H_TRPH1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.97A	3fi0H-3h0gA: undetectable	3fi0H-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_I_TRPI1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 8	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.95A	3fi0I-3h0gA: undetectable	3fi0I-3h0gA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_J_TRPJ1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.94A	3fi0J-3h0gA: undetectable	3fi0J-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_K_TRPK1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.98A	3fi0K-3h0gA: undetectable	3fi0K-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_L_TRPL1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.01A	3fi0L-3h0gA: undetectable	3fi0L-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_M_TRPM1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.02A	3fi0M-3h0gA: undetectable	3fi0M-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_N_TRPN1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	0.95A	3fi0N-3h0gA: undetectable	3fi0N-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_O_TRPO1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.00A	3fi0O-3h0gA: undetectable	3fi0O-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_P_TRPP1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	GLY B 966 GLN B 964 VAL B1088 ILE A 359	None	0.92A	3fi0P-3h0gB: undetectable	3fi0P-3h0gB: 13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_R_TRPR1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 9	GLY A1068 HIS A1373 VAL A 856 VAL A 862 GLN A 871	None	1.00A	3fi0R-3h0gA: undetectable	3fi0R-3h0gA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_A_SAMA500_1 (PCZA361.24)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ARG B 379 GLU B 683 ASP B 678	None	0.78A	3g2oA-3h0gB: undetectable	3g2oA-3h0gB: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_D_ROFD904_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASN B 811 MET B 767 PHE B 840	None	0.99A	3g4lD-3h0gB: undetectable	3g4lD-3h0gB: 15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HAM_A_LLLA500_1 (AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	ASN B 721 ASP A 797 SER B 690 ASP B 693 ARG A 693	None	1.03A	3hamA-3h0gB: 0.3	3hamA-3h0gB: 12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE P)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 8	VAL C 236 TRP C 171 ILE J   5 GLY J  11	None	0.58A	3hjoA-3h0gC: undetectable	3hjoA-3h0gC: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE P)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 8	VAL C 236 TRP C 171 ILE J   5 GLY J  11	None	0.57A	3hjoB-3h0gC: undetectable	3hjoB-3h0gC: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ID5_B_SAMB301_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 11	GLY A 867 THR A1400 ASP A 859 ASP A 868 ILE A 869	None	1.38A	3id5B-3h0gA: undetectable	3id5B-3h0gA: 10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ID5_F_SAMF301_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 11	GLY A 867 THR A1400 ASP A 859 ASP A 868 ILE A 869	None	1.38A	3id5F-3h0gA: undetectable	3id5F-3h0gA: 10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_C_SAMC301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	PRO J  64 THR C  54 ASP C 121 ILE C 117 LEU C 148	None	1.36A	3iv6C-3h0gJ: undetectable	3iv6C-3h0gJ: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX2_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 7	VAL B 685 ARG B 590 VAL B 602 GLU B 682	None	1.19A	3jx2A-3h0gB: undetectable 3jx2B-3h0gB: undetectable	3jx2A-3h0gB: 15.45 3jx2B-3h0gB: 15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX6_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 7	VAL B 685 ARG B 590 VAL B 602 GLU B 682	None	1.19A	3jx6A-3h0gB: 0.3 3jx6B-3h0gB: 0.3	3jx6A-3h0gB: 15.45 3jx6B-3h0gB: 15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_A_THHA642_1 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASN B 206 ASP B 615 ARG B 408	None	0.79A	3k13A-3h0gB: undetectable	3k13A-3h0gB: 13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_E_TFPE201_1 (PROTEIN S100-A4)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 7	PHE B  41 GLY B 396 MET B 158 PHE B 163	None	1.11A	3ko0D-3h0gB: undetectable 3ko0E-3h0gB: undetectable	3ko0D-3h0gB: 6.27 3ko0E-3h0gB: 6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP3_B_AICB2002_1 (TRANSCRIPTIONAL REGULATOR TCAR)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 (Schizosaccharomy ces pombe)	3 / 3	ALA A1152 ARG I  45 LYS I  42	None	1.05A	3kp3B-3h0gA: undetectable	3kp3B-3h0gA: 7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP5_B_KANB2002_1 (TRANSCRIPTIONAL REGULATOR TCAR)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 (Schizosaccharomy ces pombe)	3 / 3	ALA A1152 ARG I  45 LYS I  42	None	1.04A	3kp5B-3h0gA: undetectable	3kp5B-3h0gA: 7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LD6_A_KKKA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	PHE C  19 TRP K 108 ALA C  29 THR C  24 ILE K 100	None	1.30A	3ld6A-3h0gC: undetectable	3ld6A-3h0gC: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LK0_D_Z80D92_1 (PROTEIN S100-B)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	HIS A 637 PHE A 651 PHE A 652	None	0.61A	3lk0D-3h0gA: undetectable	3lk0D-3h0gA: 5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LOQ_A_ACTA279_0 (UNIVERSAL STRESS PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe)	4 / 4	SER H   2 SER H  61 THR H  60 SER H   4	None	1.14A	3loqA-3h0gH: undetectable	3loqA-3h0gH: 18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N9J_A_EAAA210_1 (GLUTATHIONE S-TRANSFERASE P)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 8	VAL C 236 TRP C 171 ILE J   5 GLY J  11	None	0.76A	3n9jA-3h0gC: undetectable	3n9jA-3h0gC: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLJ_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 7	VAL B 685 ARG B 590 VAL B 602 GLU B 682	None	1.21A	3nljA-3h0gB: 0.5 3nljB-3h0gB: undetectable	3nljA-3h0gB: 15.45 3nljB-3h0gB: 15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_B_SAMB201_0 (YAEB-LIKE PROTEIN RPA0152)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	LYS A 750 ARG A 538 LYS A 600	None	1.33A	3okxA-3h0gA: undetectable	3okxA-3h0gA: 7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEL_D_QELD2_1 (NMDA GLUTAMATE RECEPTOR SUBUNIT GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 5	TYR B 770 THR B 473 PHE B 474 LEU B 469	None	1.17A	3qelC-3h0gB: undetectable	3qelC-3h0gB: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXV_D_MTXD2000_2 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	LEU B1140 ARG A 845 ASN A 451	None	0.75A	3qxvD-3h0gB: undetectable	3qxvD-3h0gB: 7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R0L_D_ACTD127_0 (PHOSPHOLIPASE A2 CB)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 5	PHE B 387 ILE B 619 GLY B 506 CYH B 509 HIS B 504	None	1.30A	3r0lD-3h0gB: undetectable	3r0lD-3h0gB: 7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R0L_D_ACTD127_0 (PHOSPHOLIPASE A2 CB)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 5	ILE B 813 GLY B 994 CYH J  10 HIS B 985	None None ZN  J1066 (-2.9A) None	1.40A	3r0lD-3h0gB: undetectable	3r0lD-3h0gB: 7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S53_A_017A201_1 (PROTEASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 9	GLY B 977 ASP A 489 ASP A 491 ILE A 359 ILE B 965	None	1.01A	3s53A-3h0gB: undetectable	3s53A-3h0gB: 5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SMT_A_SAMA1000_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD3)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 10	ARG B 984 THR K  40 ARG C  34 TYR K  60 PHE K  70	None	1.43A	3smtA-3h0gB: 0.0	3smtA-3h0gB: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_B_08JB2_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe)	4 / 7	VAL E 179 LEU E 183 LEU E 185 ILE E 193	None	1.00A	3u5kB-3h0gE: undetectable	3u5kB-3h0gE: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_A_SAMA301_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	SER A1407 ASP A 853 ASP A 868	None	0.52A	3uj7A-3h0gA: undetectable	3uj7A-3h0gA: 9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_B_SAMB302_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 5	TYR A 620 SER A 604 ASP A 608 ASP A 624	None	1.30A	3uj7B-3h0gA: undetectable	3uj7B-3h0gA: 9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_B_TYLB1187_1 (BROMODOMAIN CONTAINING 2)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe)	4 / 5	VAL E 179 LEU E 183 LEU E 185 ILE E 193	None	0.95A	4a9jB-3h0gE: undetectable	4a9jB-3h0gE: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_B_DXCB1473_0 (TRANSLATION ELONGATION FACTOR SELB)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 8	ILE A 672 GLY A 671 PHE B1075 VAL B1044 SER B1024	None	1.19A	4acbB-3h0gA: undetectable 4acbC-3h0gA: undetectable	4acbB-3h0gA: 16.45 4acbC-3h0gA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AT0_A_ACTA1490_0 (3-KETOSTEROID-DELTA4 -5ALPHA-DEHYDROGENAS E)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	3 / 3	GLU A 876 TYR E 203 SER E 205	None	0.81A	4at0A-3h0gA: undetectable	4at0A-3h0gA: 15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B9Z_A_ACRA1818_1 (ALPHA-GLUCOSIDASE, PUTATIVE, ADG31B)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	5 / 12	ASP J  54 ILE J  56 TYR C 118 ARG C  65 HIS J  52	None	1.24A	4b9zA-3h0gJ: undetectable	4b9zA-3h0gJ: 6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C8B_B_0LIB1000_2 (RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	TYR B1062 MET B1061 ILE B 813	None	0.92A	4c8bB-3h0gB: undetectable	4c8bB-3h0gB: 14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX3_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 7	VAL B 685 ARG B 590 VAL B 602 GLU B 682	None	1.18A	4cx3A-3h0gB: 0.2 4cx3B-3h0gB: undetectable	4cx3A-3h0gB: 15.45 4cx3B-3h0gB: 15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D33_A_ACTA860_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 5	GLY H  99 ILE A 619 VAL A 570 SER H  96	None	1.24A	4d33A-3h0gH: undetectable	4d33A-3h0gH: 14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D33_B_ACTB860_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 5	GLY H  99 ILE A 619 VAL A 570 SER H  96	None	1.24A	4d33B-3h0gH: undetectable	4d33B-3h0gH: 14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_A_C2FA300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	PHE B  25 ILE B 687 GLY B 506 SER B 526 ARG B 482	None	1.49A	4djfA-3h0gB: undetectable	4djfA-3h0gB: 12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DV1_A_SRYA1601_1 (16S RRNA RIBOSOMAL PROTEIN S12)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	LYS A 575 LYS A 573 PRO A 574	None	1.25A	4dv1L-3h0gA: undetectable	4dv1L-3h0gA: 6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F4D_A_CHDA505_0 (FERROCHELATASE, MITOCHONDRIAL)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 7	MET A 495 ILE A 442 ARG A 440 MET A 512	None	1.50A	4f4dA-3h0gA: undetectable	4f4dA-3h0gA: 12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F93_B_SANB3004_1 (U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	GLU B 680 GLU B 598 GLY B 617 SER B 532	None	0.97A	4f93B-3h0gB: undetectable	4f93B-3h0gB: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU9_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	GLN B 343 THR B 352 THR B 351	None	0.76A	4fu9A-3h0gB: undetectable	4fu9A-3h0gB: 12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUF_A_ACTA310_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	GLN B 343 THR B 352 THR B 351	None	0.75A	4fufA-3h0gB: undetectable	4fufA-3h0gB: 12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JVL_A_ESTA702_1 (ESTROGEN SULFOTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe)	4 / 9	PHE E  41 HIS E  45 PHE E  76 ILE E 136	None	0.84A	4jvlA-3h0gE: undetectable	4jvlA-3h0gE: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.92A	4k6iA-3h0gK: undetectable	4k6iA-3h0gK: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KFJ_B_FOLB202_0 (DIHYDROFOLATE REDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	ILE J   2 LEU C  66 ARG C 141 ILE C 154 LEU C 148	None	1.07A	4kfjB-3h0gJ: undetectable	4kfjB-3h0gJ: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	LEU A 959 PRO A 960 ARG A1026	None	0.52A	4klrB-3h0gA: undetectable	4klrB-3h0gA: 12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LAX_A_FK5A301_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Schizosaccharomy ces pombe)	5 / 10	ASP H  41 VAL A 570 ILE A 571 TYR H  74 PHE A 546	None	1.26A	4laxA-3h0gH: undetectable	4laxA-3h0gH: 16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMF_A_29QA603_1 (TRANSPORTER)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 9	VAL C 177 ALA C 178 GLY B1064 PHE B 990 GLY B 994	None	1.37A	4mmfA-3h0gC: undetectable	4mmfA-3h0gC: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMF_B_29QB603_1 (TRANSPORTER)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 9	VAL C 177 ALA C 178 GLY B1064 PHE B 990 GLY B 994	None	1.36A	4mmfB-3h0gC: undetectable	4mmfB-3h0gC: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWV_A_BCZA513_1 (NEURAMINIDASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ARG B 105 GLU B 179 ARG B 471	None	0.71A	4mwvA-3h0gB: undetectable	4mwvA-3h0gB: 14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWZ_A_SAMA301_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	SER A1407 ASP A 853 ASP A 868	None	0.51A	4mwzA-3h0gA: undetectable	4mwzA-3h0gA: 11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N48_A_SAMA601_0 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 12	GLY A 407 PRO A 406 ASN A 400 ILE A 411 LEU A 432	None	0.95A	4n48A-3h0gA: undetectable	4n48A-3h0gA: 12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N49_A_SAMA601_0 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 12	GLY A 407 PRO A 406 ASN A 400 ILE A 411 LEU A 432	None	0.98A	4n49A-3h0gA: undetectable	4n49A-3h0gA: 12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_B_AERB601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 5	TYR B1183 ARG B1148 ASP A  78 VAL B1100	None	1.48A	4nkvB-3h0gB: undetectable	4nkvB-3h0gB: 16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O4D_A_ACTA406_0 (INOSITOL HEXAKISPHOSPHATE KINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	ASP A1379 THR A1382 ARG E 207 SER E 205	None	1.32A	4o4dA-3h0gA: 1.7	4o4dA-3h0gA: 9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD4_C_AOQC4003_1 (CYTOCHROME B)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	PHE B  38 ILE B 190 PRO B 156 LEU B 402 ILE B  49	None	1.07A	4pd4C-3h0gB: undetectable	4pd4C-3h0gB: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PSS_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	LEU C  62 ALA C  63 PHE C  61 ILE J   2 TYR B 774	None	0.87A	4pssA-3h0gC: undetectable	4pssA-3h0gC: 19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PST_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ILE B 157 ASP B  39 ARG B  86	None	0.84A	4pstA-3h0gB: undetectable	4pstA-3h0gB: 8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PSY_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	LEU C  62 ALA C  63 PHE C  61 ILE J   2 TYR B 774	None	0.83A	4psyA-3h0gC: undetectable	4psyA-3h0gC: 19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTM_A_SAMA301_0 (DNA ADENINE METHYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	GLY B 821 GLY A 361 SER A 472 TYR B 983 GLN K   3	None	1.02A	4rtmA-3h0gB: undetectable	4rtmA-3h0gB: 13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_A_STRA604_1 (CYTOCHROME P450 21-HYDROXYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	VAL B1016 LEU B1015 ILE A 672 GLY A 673 VAL A 749	None	0.94A	4y8wA-3h0gB: undetectable	4y8wA-3h0gB: 16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_B_STRB603_1 (CYTOCHROME P450 21-HYDROXYLASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	5 / 12	VAL B1016 LEU B1015 ILE A 672 GLY A 673 VAL A 749	None	0.91A	4y8wB-3h0gB: undetectable	4y8wB-3h0gB: 16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YMG_B_SAMB1001_1 (PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	SER B 535 GLU B 681 GLU B 584	None	0.85A	4ymgB-3h0gB: undetectable	4ymgB-3h0gB: 12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YO9_B_ACTB401_0 (3C-LIKE PROTEINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	3 / 3	ARG A 863 ASP A 859 TYR E 163	None	0.94A	4yo9B-3h0gA: undetectable	4yo9B-3h0gA: 12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	GLY A 171 ASP A 118 GLY A 174 SER A 221	None	1.02A	4z53A-3h0gA: undetectable 4z53B-3h0gA: 3.2	4z53A-3h0gA: 18.97 4z53B-3h0gA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B3S_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	LYS G   3 LEU G   5 PHE A1496 LEU G  50	None	0.85A	5b3sP-3h0gG: undetectable	5b3sP-3h0gG: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_N_EVPN2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	SER A 221 GLY A 171 ASP A 118 GLY A 174	None	0.90A	5cdnR-3h0gA: 3.2 5cdnS-3h0gA: undetectable	5cdnR-3h0gA: 16.65 5cdnS-3h0gA: 9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DBY_A_ACTA617_0 (SERUM ALBUMIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	TRP A 436 ARG A 413 LEU A 421	None	0.90A	5dbyA-3h0gA: undetectable	5dbyA-3h0gA: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DQF_A_LCRA612_1 (SERUM ALBUMIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe)	5 / 9	ASP D  23 LEU G   5 LEU G  79 LEU G   8 ALA G  77	None	0.99A	5dqfA-3h0gD: undetectable	5dqfA-3h0gD: 13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DSG_A_0HKA1201_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYS IN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	ASN B 831 LEU B1076 PHE B 990	None	0.80A	5dsgA-3h0gB: undetectable	5dsgA-3h0gB: 14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_Z_BEZZ801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 BEZ-LEU-LEU)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 4	ILE B 900 GLY B 886 ILE B 899 LEU B 887	None	0.87A	5dzkl-3h0gB: undetectable 5dzkz-3h0gB: undetectable	5dzkl-3h0gB: 10.26 5dzkz-3h0gB: 0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E8Q_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	3 / 3	ASP A 266 LEU B1190 ARG A 341	None	0.85A	5e8qA-3h0gA: undetectable	5e8qA-3h0gA: 7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECN_D_LEUD602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	ILE B 152 ALA B 433 VAL B 414 VAL B 150	None	0.86A	5ecnD-3h0gB: undetectable	5ecnD-3h0gB: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF8_B_LBHB2004_1 (HDAC6 PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe)	5 / 12	ASP E 134 HIS E 141 ASP E  24 LEU E  21 TYR E 182	None	1.45A	5ef8B-3h0gE: undetectable	5ef8B-3h0gE: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GTR_A_ESTA601_2 (ESTROGEN RECEPTOR)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 5	LEU B 478 LEU B 469 PHE B 474 LEU B 771	None	1.03A	5gtrA-3h0gB: undetectable	5gtrA-3h0gB: 12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H4D_A_BBIA403_1 (NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	PHE A 783 GLU A 721 PHE A 720 VAL A 696	None	1.26A	5h4dA-3h0gA: undetectable	5h4dA-3h0gA: 10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HP1_C_PPFC601_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 6	ARG B 755 ASP A 489 GLY B 977 ASP B 826	None	1.23A	5hp1C-3h0gB: undetectable	5hp1C-3h0gB: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKR_A_ID8A601_2 (PROSTAGLANDIN G/H SYNTHASE 2)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	3 / 3	VAL B1151 LEU A 346 MET A1435	None	0.68A	5ikrA-3h0gB: undetectable	5ikrA-3h0gB: 18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB603_1 (PHIAB6 TAILSPIKE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	3 / 3	VAL A 447 GLU A 384 GLU A 501	None	0.79A	5jsdB-3h0gA: undetectable 5jsdC-3h0gA: undetectable	5jsdB-3h0gA: 17.07 5jsdC-3h0gA: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB603_1 (PHIAB6 TAILSPIKE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	3 / 3	VAL B1041 GLU C 201 GLU C 195	None	0.78A	5jsdB-3h0gB: undetectable 5jsdC-3h0gB: undetectable	5jsdB-3h0gB: 20.47 5jsdC-3h0gB: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KF8_A_GCSA404_1 (PREDICTED ACETYLTRANSFERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe)	4 / 8	ARG B1113 GLU B 897 PRO B 929 GLY B 877	None	1.11A	5kf8A-3h0gB: undetectable	5kf8A-3h0gB: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJB_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 12	PHE A  97 LEU A1415 ALA A1419 PHE A  21 LEU A 245	None	1.41A	5ljbA-3h0gA: undetectable	5ljbA-3h0gA: 6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5K_A_HAEA306_1 (MACROPHAGE METALLOELASTASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	4 / 5	ILE C 164 HIS K  39 GLU B 986 HIS K  68	None	1.02A	5n5kA-3h0gC: undetectable	5n5kA-3h0gC: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_A_SAMA501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	LEU A 335 GLY A 337 LEU B1191 ASN A 345 LEU A 346	None	0.92A	5nfjA-3h0gA: undetectable	5nfjA-3h0gA: 8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZY_A_CE3A1102_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 7	THR A1144 GLN A1140 ILE A1141 GLY A1281	None	0.94A	5nzyA-3h0gA: undetectable	5nzyA-3h0gA: 11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODQ_A_ACTA703_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 6	ARG A 737 ALA A 735 PHE A 761 GLU A 740	None	1.24A	5odqA-3h0gA: undetectable	5odqA-3h0gA: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_A_CUA601_0 (THIOCYANATE DEHYDROGENASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (Schizosaccharomy ces pombe)	3 / 3	HIS K  68 ASP K  38 HIS K  39	None	0.81A	5oexA-3h0gK: undetectable	5oexA-3h0gK: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1805_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	PHE A 820 HIS A 792 PRO A 791 ILE B 687	None	0.90A	5vkqA-3h0gA: 3.1 5vkqD-3h0gA: 3.1	5vkqA-3h0gA: 22.63 5vkqD-3h0gA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1802_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	PHE A 820 HIS A 792 PRO A 791 ILE B 687	None	0.92A	5vkqA-3h0gA: 3.1 5vkqB-3h0gA: 3.2	5vkqA-3h0gA: 22.63 5vkqB-3h0gA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 8	PHE A 820 HIS A 792 PRO A 791 ILE B 687	None	0.88A	5vkqB-3h0gA: 3.2 5vkqC-3h0gA: 3.1	5vkqB-3h0gA: 22.63 5vkqC-3h0gA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 7	PHE A 820 HIS A 792 PRO A 791 ILE B 687	None	0.89A	5vkqC-3h0gA: 3.1 5vkqD-3h0gA: 3.1	5vkqC-3h0gA: 22.63 5vkqD-3h0gA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 6	LYS G   3 LEU G   5 PHE A1496 LEU G  50	None	0.87A	5w97C-3h0gG: undetectable 5w97J-3h0gG: undetectable	5w97C-3h0gG: 22.22 5w97J-3h0gG: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X2S_I_PEMI202_1 (HEMOGLOBIN SUBUNIT ALPHA HEMOGLOBIN SUBUNIT BETA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (Schizosaccharomy ces pombe)	4 / 8	PRO K  16 LYS K  36 THR K  33 THR K  19	None	1.30A	5x2sI-3h0gK: undetectable 5x2sJ-3h0gK: undetectable 5x2sK-3h0gK: undetectable	5x2sI-3h0gK: 22.93 5x2sJ-3h0gK: 19.87 5x2sK-3h0gK: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YCN_A_8LXA501_0 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	ILE A1347 GLY A1346 VAL E 191 ILE E 193 LEU E 135	None	0.99A	5ycnA-3h0gA: undetectable	5ycnA-3h0gA: 11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z12_B_9CRB501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (Schizosaccharomy ces pombe)	5 / 12	ILE K  86 ALA K  89 ALA K  90 LEU C 256 LEU K  49	None	0.95A	5z12B-3h0gK: undetectable	5z12B-3h0gK: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BEC_C_RBTC601_1 (SCAFFOLD PROTEIN D13)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	5 / 12	VAL A 961 VAL A1034 PHE A1021 ILE A 989 PHE A1029	None	1.33A	6becA-3h0gA: undetectable 6becB-3h0gA: undetectable 6becC-3h0gA: undetectable	6becA-3h0gA: 16.15 6becB-3h0gA: 16.15 6becC-3h0gA: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECF_I_DVAI3010_0 (VLM2 DODECADEPSIPEPTIDE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	3 / 3	PHE A   6 ARG A 418 ALA B1146	None	0.96A	6ecfB-3h0gA: undetectable	6ecfB-3h0gA: 11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_A_SAMA501_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	ILE A 670 ILE A 672 ILE B1001 VAL B 814 ILE B 816	None	0.99A	6emuA-3h0gA: undetectable	6emuA-3h0gA: 9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_C_SAMC301_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	ILE A 670 ILE A 672 ILE B1001 VAL B 814 ILE B 816	None	1.00A	6emuC-3h0gA: undetectable	6emuC-3h0gA: 9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_2 (TUBULIN BETA CHAIN)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 5	LEU J  35 THR J  51 ARG J  42 ARG J   6	None	1.32A	6ew0B-3h0gJ: undetectable	6ew0B-3h0gJ: 27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_2 (TUBULIN BETA CHAIN)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 5	LEU J  35 THR J  51 ARG J  42 ARG J   6	None	1.32A	6ew0D-3h0gJ: undetectable	6ew0D-3h0gJ: 27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_2 (TUBULIN BETA CHAIN)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 5	LEU J  35 THR J  51 ARG J  42 ARG J   6	None	1.33A	6ew0H-3h0gJ: undetectable	6ew0H-3h0gJ: 27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_2 (TUBULIN BETA CHAIN)	3h0g	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe)	4 / 5	LEU J  35 THR J  51 ARG J  42 ARG J   6	None	1.32A	6ew0I-3h0gJ: undetectable	6ew0I-3h0gJ: 27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_D_ADND502_1 (ADENOSYLHOMOCYSTEINA SE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	3 / 3	LEU A 272 ASN B1199 LEU A  88	None	0.47A	6exiD-3h0gA: undetectable	6exiD-3h0gA: 4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6S_A_CXQA507_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Schizosaccharomy ces pombe)	4 / 5	ARG A 538 ALA A 535 GLN A 751 ILE A 670	None	1.40A	6f6sA-3h0gA: undetectable 6f6sB-3h0gA: undetectable	6f6sA-3h0gA: 4.66 6f6sB-3h0gA: 4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6N91_A_DCFA401_1 (ADENOSINE DEAMINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 4	HIS B 985 LEU B1076 TYR J  43 GLY B 994	None	1.16A	6n91A-3h0gB: undetectable	6n91A-3h0gB: 5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6N91_B_DCFB401_1 (ADENOSINE DEAMINASE)	3h0g	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	4 / 4	HIS B 985 LEU B1076 TYR J  43 GLY B 994	None	1.18A	6n91B-3h0gB: undetectable	6n91B-3h0gB: 5.39