SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 ALA A 160
THR A 115
ILE A  69
GLY A 149
SER A 154
 None
 1.20A 1c9sQ-3h0lA:
undetectable
1c9sR-3h0lA:
undetectable		 1c9sQ-3h0lA:
10.90
1c9sR-3h0lA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 GLY A 149
SER A 154
ALA A 160
THR A 115
ILE A  69
 None
 1.20A 1gtfD-3h0lA:
undetectable
1gtfE-3h0lA:
undetectable		 1gtfD-3h0lA:
10.90
1gtfE-3h0lA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 ALA A 160
THR A 115
ILE A  69
GLY A 149
SER A 154
 None
 1.21A 1gtfR-3h0lA:
undetectable
1gtfS-3h0lA:
undetectable		 1gtfR-3h0lA:
10.90
1gtfS-3h0lA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 10 GLY A 146
ALA A 152
THR A 134
SER A 154
ALA A 153
 None
 1.48A 1gtnO-3h0lA:
undetectable
1gtnP-3h0lA:
undetectable		 1gtnO-3h0lA:
10.90
1gtnP-3h0lA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 GLY A 146
ALA A 152
THR A 134
SER A 154
ALA A 153
 None
 1.49A 1gtnQ-3h0lA:
undetectable
1gtnR-3h0lA:
undetectable		 1gtnQ-3h0lA:
10.90
1gtnR-3h0lA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 VAL A 100
ILE A  75
GLY A 165
ILE A 172
ILE A 223
 None
 1.00A 1hpvA-3h0lA:
undetectable		 1hpvA-3h0lA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 5 ARG A 316
ASP A 230
SER A 192
SER A 201
 None
 1.26A 1kiaB-3h0lA:
undetectable		 1kiaB-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 6 ARG A 316
ASP A 230
SER A 192
SER A 201
 None
 1.24A 1kiaC-3h0lA:
undetectable		 1kiaC-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 GLY A 170
VAL A 422
SER A 166
SER A 124
TYR A 303
 ASN  A 901 (-3.6A)
None
None
ASN  A 901 (-3.0A)
None
 1.21A 1kiaD-3h0lA:
undetectable		 1kiaD-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 GLY A 170
VAL A 422
SER A 166
SER A 124
TYR A 303
 ASN  A 901 (-3.6A)
None
None
ASN  A 901 (-3.0A)
None
 1.20A 1nbhA-3h0lA:
undetectable		 1nbhA-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 GLY A 170
VAL A 422
SER A 166
SER A 124
TYR A 303
 ASN  A 901 (-3.6A)
None
None
ASN  A 901 (-3.0A)
None
 1.21A 1nbhC-3h0lA:
undetectable		 1nbhC-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 GLY A 170
VAL A 422
SER A 166
SER A 124
TYR A 303
 ASN  A 901 (-3.6A)
None
None
ASN  A 901 (-3.0A)
None
 1.21A 1nbhD-3h0lA:
undetectable		 1nbhD-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 8 ASP A 118
GLY A 123
GLY A 146
GLY A 145
 None
ASN  A 901 (-3.2A)
None
None
 0.62A 1qzzA-3h0lA:
undetectable		 1qzzA-3h0lA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 LEU A 220
LEU A 459
ALA A 431
ALA A 424
ASP A 454
 None
 0.96A 2bm9F-3h0lA:
undetectable		 2bm9F-3h0lA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 11 LEU A  89
ILE A  88
VAL A 348
GLY A 345
LEU A 314
 None
 1.27A 2bxeA-3h0lA:
undetectable		 2bxeA-3h0lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 7 PHE A  92
TYR A 322
THR A  82
VAL A 197
 None
 1.05A 2cppA-3h0lA:
undetectable		 2cppA-3h0lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 7 LEU A 420
THR A 397
PRO A 398
GLY A 145
 None
 0.87A 2ddwB-3h0lA:
undetectable		 2ddwB-3h0lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 6 TYR A 303
GLY A 123
TYR A 302
ASP A 118
 None
ASN  A 901 (-3.2A)
ASN  A 901 (-4.6A)
None
 1.27A 2g72A-3h0lA:
undetectable		 2g72A-3h0lA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 6 VAL A  39
PHE A 132
PRO A 133
THR A 126
 None
 1.25A 2q6oB-3h0lA:
undetectable		 2q6oB-3h0lA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 PRO A 186
ILE A 223
LEU A 196
LEU A 164
ILE A  75
 None
 1.10A 3a50E-3h0lA:
undetectable		 3a50E-3h0lA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 8 SER A 163
ALA A 153
CYH A 179
THR A 126
 None
 0.84A 3bpxA-3h0lA:
undetectable
3bpxB-3h0lA:
undetectable		 3bpxA-3h0lA:
17.22
3bpxB-3h0lA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 7 THR A 213
VAL A 216
ILE A 184
ILE A 432
 None
 0.70A 3deuA-3h0lA:
undetectable		 3deuA-3h0lA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 7 TYR A 302
GLY A 169
TYR A 188
ARG A 375
 ASN  A 901 (-4.6A)
ASN  A 901 (-3.8A)
None
None
 0.86A 3elzA-3h0lA:
0.0		 3elzA-3h0lA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 LEU A 426
ASN A 425
GLY A 428
ARG A 376
ILE A 449
 None
 1.42A 3h52A-3h0lA:
undetectable		 3h52A-3h0lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 VAL A  77
ALA A  98
ILE A 206
PHE A 209
ILE A 111
 None
 1.43A 3hbbB-3h0lA:
undetectable		 3hbbB-3h0lA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 LEU A  13
LEU A  10
ARG A 212
 None
 0.68A 3hcnB-3h0lA:
undetectable		 3hcnB-3h0lA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 ASN A  74
ASP A 204
ARG A 350
 None
 0.92A 3k13C-3h0lA:
undetectable		 3k13C-3h0lA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 ILE A 299
ASP A 418
PHE A 276
ILE A 436
THR A 396
 None
ASN  A 901 (-3.2A)
None
None
None
 0.98A 3pwwA-3h0lA:
undetectable		 3pwwA-3h0lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 PHE A 178
GLN A 447
PHE A 402
 None
 0.82A 3rv5A-3h0lA:
undetectable		 3rv5A-3h0lA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 PHE A 131
PHE A 132
ASN A 116
ILE A  43
THR A  82
 None
 1.43A 3t3rC-3h0lA:
undetectable		 3t3rC-3h0lA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 ARG A 142
PRO A 398
PHE A 178
 None
 0.83A 3thrC-3h0lA:
undetectable		 3thrC-3h0lA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 SER A 433
GLN A 174
THR A 396
GLN A 447
LEU A 426
 None
 1.49A 4abzA-3h0lA:
undetectable		 4abzA-3h0lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 9 ALA A  50
ALA A 109
GLY A 108
ILE A  67
ILE A  69
 None
 1.05A 4eatB-3h0lA:
undetectable		 4eatB-3h0lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 4 GLU A 309
ASP A 204
ARG A 316
THR A 168
 None
 1.38A 4ej1A-3h0lA:
0.4		 4ej1A-3h0lA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 8 PHE A  92
TYR A 322
THR A  82
VAL A 197
 None
 1.04A 4l4eA-3h0lA:
undetectable		 4l4eA-3h0lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 8 PHE A  92
TYR A 322
THR A  82
VAL A 197
 None
 1.04A 4l4fA-3h0lA:
undetectable		 4l4fA-3h0lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 7 VAL A 216
ILE A 432
ARG A 173
ILE A 434
 None
 0.92A 4lv9B-3h0lA:
undetectable		 4lv9B-3h0lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 ALA A 424
GLN A 174
GLY A 145
 None
 0.65A 4odoC-3h0lA:
undetectable		 4odoC-3h0lA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 7 SER A 224
ASP A 167
ARG A 173
GLY A 183
 None
 1.01A 5btfA-3h0lA:
0.4
5btfC-3h0lA:
0.6
5btfD-3h0lA:
undetectable		 5btfA-3h0lA:
21.88
5btfC-3h0lA:
21.88
5btfD-3h0lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 6 SER A 224
ASP A 167
ARG A 173
GLY A 183
 None
 0.78A 5cdqA-3h0lA:
0.9
5cdqC-3h0lA:
undetectable
5cdqD-3h0lA:
undetectable		 5cdqA-3h0lA:
21.36
5cdqC-3h0lA:
21.36
5cdqD-3h0lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 4 LEU A 110
ILE A 111
GLY A 108
ILE A 101
 None
 0.81A 5dzk3-3h0lA:
undetectable
5dzkm-3h0lA:
undetectable		 5dzk3-3h0lA:
28.57
5dzkm-3h0lA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 5 ILE A 111
GLY A 108
ILE A 101
LEU A 110
 None
 0.83A 5dzkB-3h0lA:
undetectable
5dzkI-3h0lA:
undetectable
5dzkW-3h0lA:
undetectable		 5dzkB-3h0lA:
19.70
5dzkI-3h0lA:
17.44
5dzkW-3h0lA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 5 ILE A 111
GLY A 108
ILE A 101
LEU A 110
 None
 0.86A 5dzki-3h0lA:
undetectable
5dzkj-3h0lA:
undetectable
5dzkx-3h0lA:
undetectable		 5dzki-3h0lA:
17.44
5dzkj-3h0lA:
17.44
5dzkx-3h0lA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 ALA A  70
GLY A 113
GLY A 150
SER A 154
LEU A 158
 None
 0.95A 5gwxA-3h0lA:
undetectable		 5gwxA-3h0lA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 ALA A 176
GLY A 180
GLY A 210
GLY A 445
SER A 433
 None
 1.12A 5gwxA-3h0lA:
undetectable		 5gwxA-3h0lA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 11 ILE A 223
ILE A 101
VAL A 162
VAL A 216
LEU A  64
 None
 1.31A 5jkwA-3h0lA:
undetectable		 5jkwA-3h0lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 8 LEU A 458
ILE A 449
ALA A 424
PRO A 239
 None
 0.90A 5m0oC-3h0lA:
undetectable		 5m0oC-3h0lA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 10 PRO A 267
ALA A 272
GLY A 445
THR A 396
ILE A 436
 None
 1.32A 5vyhA-3h0lA:
undetectable		 5vyhA-3h0lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 8 VAL A 181
PRO A 144
GLN A 174
GLY A 146
 None
 0.93A 5w3jB-3h0lA:
undetectable		 5w3jB-3h0lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		4 / 4 GLY A 428
ARG A 173
ASN A 425
LEU A 429
 None
 1.13A 6b58A-3h0lA:
undetectable		 6b58A-3h0lA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		5 / 12 GLY A 183
ILE A 182
THR A 213
ILE A 449
VAL A 391
 None
 1.07A 6emuC-3h0lA:
undetectable		 6emuC-3h0lA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 ASN A 136
PRO A 144
GLN A 174
 None
 0.86A 6jnhA-3h0lA:
undetectable		 6jnhA-3h0lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Aquifex
aeolicus) 		3 / 3 ASN A 136
PRO A 144
GLN A 174
 None
 0.85A 6jogA-3h0lA:
undetectable		 6jogA-3h0lA:
18.63